Med Biol Eng Comput - Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma.

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Resumo

Intestinal injuries are responsible for significant morbidity and mortality arising from trauma to the abdomen. The biomechanical characterisation of the small intestine allows for the understanding of the pathophysiological mechanisms responsible for these injuries. Studies reported in the literature focus principally on quasi-static tests, which do not take into account the stresses experienced during high kinetic trauma. In addition, the use of embalmed human tissue can alter the recorded response. The stress-strain curves from 43 tensile tests performed at 1 m/s were analysed. Samples were prepared from four fresh human intestines and from four embalmed cadaveric intestines. The data indicated a two-phase response, with each response consisting of a quasi-linear increase in the stress followed by an inflection in the curve before a peak preceding the loss of stress. The fresh tissue was more deformable than the embalmed tissue, and its first peak stress was lower (P = 0.034). A complementary histological analysis was performed. The results of the analysis enable an investigation of the response of the intestinal wall layers to stress as a two-layer structure and highlight the high sensitivity of the structure's mechanical behaviour to the speed of loading and the method of preservation.

Resumo Limpo

intestin injuri respons signific morbid mortal aris trauma abdomen biomechan characteris small intestin allow understand pathophysiolog mechan respons injuri studi report literatur focus princip quasistat test take account stress experienc high kinet trauma addit use embalm human tissu can alter record respons stressstrain curv tensil test perform ms analys sampl prepar four fresh human intestin four embalm cadaver intestin data indic twophas respons respons consist quasilinear increas stress follow inflect curv peak preced loss stress fresh tissu deform embalm tissu first peak stress lower p complementari histolog analysi perform result analysi enabl investig respons intestin wall layer stress twolay structur highlight high sensit structur mechan behaviour speed load method preserv

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