Med Biol Eng Comput - Mechanical behaviour and rupture of normal and pathological human ascending aortic wall.


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The mechanical properties of aortic wall, both healthy and pathological, are needed in order to develop and improve diagnostic and interventional criteria, and for the development of mechanical models to assess arterial integrity. This study focuses on the mechanical behaviour and rupture conditions of the human ascending aorta and its relationship with age and pathologies. Fresh ascending aortic specimens harvested from 23 healthy donors, 12 patients with bicuspid aortic valve (BAV) and 14 with aneurysm were tensile-tested in vitro under physiological conditions. Tensile strength, stretch at failure and elbow stress were measured. The obtained results showed that age causes a major reduction in the mechanical parameters of healthy ascending aortic tissue, and that no significant differences are found between the mechanical strength of aneurysmal or BAV aortic specimens and the corresponding age-matched control group. The physiological level of the stress in the circumferential direction was also computed to assess the physiological operation range of healthy and diseased ascending aortas. The mean physiological wall stress acting on pathologic aortas was found to be far from rupture, with factors of safety (defined as the ratio of tensile strength to the mean wall stress) larger than six. In contrast, the physiological operation of pathologic vessels lays in the stiff part of the response curve, losing part of its function of damping the pressure waves from the heart.

Resumo Limpo

mechan properti aortic wall healthi patholog need order develop improv diagnost intervent criteria develop mechan model assess arteri integr studi focus mechan behaviour ruptur condit human ascend aorta relationship age patholog fresh ascend aortic specimen harvest healthi donor patient bicuspid aortic valv bav aneurysm tensiletest vitro physiolog condit tensil strength stretch failur elbow stress measur obtain result show age caus major reduct mechan paramet healthi ascend aortic tissu signific differ found mechan strength aneurysm bav aortic specimen correspond agematch control group physiolog level stress circumferenti direct also comput assess physiolog oper rang healthi diseas ascend aorta mean physiolog wall stress act patholog aorta found far ruptur factor safeti defin ratio tensil strength mean wall stress larger six contrast physiolog oper patholog vessel lay stiff part respons curv lose part function damp pressur wave heart

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