Med Biol Eng Comput - Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation.


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While several models have proven to result in accurate estimations when measuring cardiac output using indicator dilution, the mono-exponential model has primarily been chosen for deriving coronary blood/plasma volume. In this study, we compared four models to derive coronary plasma volume using indicator dilution; the mono-exponential, power-law, gamma-variate, and local density random walk (LDRW) model. In anesthetized goats (N?=?14), we determined the distribution volume of high molecular weight (2,000?kDa) dextrans. A bolus injection (1.0?ml, 0.65?mg/ml) was given intracoronary and coronary venous blood samples were taken every 0.5-1.0?s; outflow curves were analyzed using the four aforementioned models. Measurements were done at baseline and during adenosine infusion. Absolute coronary plasma volume estimates varied by ~25% between models, while the relative volume increase during adenosine infusion was similar for all models. The gamma-variate, LDRW, and mono-exponential model resulted in volumes corresponding with literature, whereas the power-model seemed to overestimate the coronary plasma volume. The gamma-variate and LDRW model appear to be suitable alternative models to the mono-exponential model to analyze coronary indicator-dilution curves, particularly since these models are minimally influenced by outliers and do not depend on data of the descending slope of the curve only.

Resumo Limpo

sever model proven result accur estim measur cardiac output use indic dilut monoexponenti model primarili chosen deriv coronari bloodplasma volum studi compar four model deriv coronari plasma volum use indic dilut monoexponenti powerlaw gammavari local densiti random walk ldrw model anesthet goat n determin distribut volum high molecular weight kda dextran bolus inject ml mgml given intracoronari coronari venous blood sampl taken everi s outflow curv analyz use four aforement model measur done baselin adenosin infus absolut coronari plasma volum estim vari model relat volum increas adenosin infus similar model gammavari ldrw monoexponenti model result volum correspond literatur wherea powermodel seem overestim coronari plasma volum gammavari ldrw model appear suitabl altern model monoexponenti model analyz coronari indicatordilut curv particular sinc model minim influenc outlier depend data descend slope curv

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