Med Biol Eng Comput - A model for simulation and patient-specific visualization of the tissue volume of influence during brain microdialysis.

Tópicos

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Resumo

Microdialysis can be used in parallel to deep brain stimulation (DBS) to relate biochemical changes to the clinical outcome. The aim of the study was to use the finite element method to predict the tissue volume of influence (TVI(max)) and its cross-sectional radius (r (TVImax)) when using brain microdialysis, and visualize the TVI(max) in relation to patient anatomy. An equation based on Fick's law was used to simulate the TVI(max). Factorial design and regression analysis were used to investigate the impact of the diffusion coefficient, tortuosity and loss rate on the r (TVImax). A calf brain tissue experiment was performed to further evaluate these parameters. The model was implemented with pre-(MRI) and post-(CT) operative patient images for simulation of the TVI(max) for four patients undergoing microdialysis in parallel to DBS. Using physiologically relevant parameter values, the r (TVImax) for analytes with a diffusion coefficient D = 7.5 ? 106 cm?/s was estimated to 0.85 ? 0.25 mm. The simulations showed agreement with experimental data. Due to an implanted gold thread, the catheter positions were visible in the post-operative images. The TVI(max) was visualized for each catheter. The biochemical changes could thereby be related to their anatomical origin, facilitating interpretation of results.

Resumo Limpo

microdialysi can use parallel deep brain stimul dbs relat biochem chang clinic outcom aim studi use finit element method predict tissu volum influenc tvimax crosssect radius r tvimax use brain microdialysi visual tvimax relat patient anatomi equat base fick law use simul tvimax factori design regress analysi use investig impact diffus coeffici tortuos loss rate r tvimax calf brain tissu experi perform evalu paramet model implement premri postct oper patient imag simul tvimax four patient undergo microdialysi parallel dbs use physiolog relev paramet valu r tvimax analyt diffus coeffici d cms estim mm simul show agreement experiment data due implant gold thread cathet posit visibl postop imag tvimax visual cathet biochem chang therebi relat anatom origin facilit interpret result

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