Med Biol Eng Comput - Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions.

Tópicos

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Resumo

Patient-specific modeling could help in predicting vertebral osteoporotic fracture. The accuracy requirement for input data available in clinical routine is related to the model sensitivity. The objective of this study is to assess the relative impact of material properties and of loading conditions on vertebral strength using a finite element model. Fourteen subject-specific vertebral finite element models were used to investigate the effect of material properties and loading conditions. A design of experiment was set to study three parameters: Young's moduli of trabecular bone and cortico-trabecular bone (outer 3?mm of the vertebra), and load location. Cortico-trabecular bone modulus variation from 270 to 478?MPa made fracture load vary from 22 to 51%, depending on other parameters. Trabecular bone modulus variation from 115 to 258?MPa made fracture load vary from 11 to 43%. Displacing load location by 1?cm resulted in a mean decrease of 48-60% of the fracture load. Anterior bending induced strain concentration in vertebral anterior wall. Material properties of both type of bone have about the same effect. Load location is the most sensitive. Effort should be made to take into account patients' specific load distribution regarding its sagittal balance, in addition to bone properties.

Resumo Limpo

patientspecif model help predict vertebr osteoporot fractur accuraci requir input data avail clinic routin relat model sensit object studi assess relat impact materi properti load condit vertebr strength use finit element model fourteen subjectspecif vertebr finit element model use investig effect materi properti load condit design experi set studi three paramet young moduli trabecular bone corticotrabecular bone outer mm vertebra load locat corticotrabecular bone modulus variat mpa made fractur load vari depend paramet trabecular bone modulus variat mpa made fractur load vari displac load locat cm result mean decreas fractur load anterior bend induc strain concentr vertebr anterior wall materi properti type bone effect load locat sensit effort made take account patient specif load distribut regard sagitt balanc addit bone properti

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