Med Biol Eng Comput - Mathematical modeling of stem cell proliferation.

Tópicos

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Resumo

The mathematical models prevalently used to represent stem cell proliferation do not have the level of accuracy that might be desired. The hyperbolastic growth models promise a greater degree of precision in representing data of stem cell proliferation. The hyperbolastic growth model H3 is applied to experimental data in both embryonic stem cells and adult mesenchymal stem cells. In the embryonic stem cells the results are compared with other popular models, including the Deasy model, which is used prevalently for stem cell growth. In the case of modelling adult mesenchymal stem cells, H3 is also successfully applied to describe the proliferative index. We demonstrated that H3 can accurately represent the dynamics of stem cell proliferation for both embryonic and adult mesenchymal stem cells. We also recognize the importance of additional factors, such as cytokines, in determining the rate of growth. We propose the question of how to extend H3 to a multivariable model that can include the influence of growth factors.

Resumo Limpo

mathemat model preval use repres stem cell prolifer level accuraci might desir hyperbolast growth model promis greater degre precis repres data stem cell prolifer hyperbolast growth model h appli experiment data embryon stem cell adult mesenchym stem cell embryon stem cell result compar popular model includ deasi model use preval stem cell growth case model adult mesenchym stem cell h also success appli describ prolif index demonstr h can accur repres dynam stem cell prolifer embryon adult mesenchym stem cell also recogn import addit factor cytokin determin rate growth propos question extend h multivari model can includ influenc growth factor

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