Med Biol Eng Comput - Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea-hypopnea index.

Tópicos

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Resumo

Sleep apnea-hypopnea syndrome (SAHS) causes impairment of daytime functions and increases risk of cardiovascular diseases. Apnea-hypopnea index (AHI), currently used for the estimation of the severity of SAHS, does not contain information on the morphology or duration aspects of the breathing cessations and related oxygen desaturations. Longer breathing cessations and deeper desaturations may have more severe consequences than shorter and shallower ones. To address these issues, novel parameters containing information on the duration and morphology of breathing cessations and oxygen desaturations were calculated and evaluated on 160 male patients (40 patients in normal, mild, moderate and severe AHI severity categories). Obstruction and desaturation duration parameters consist of sum of event durations normalized with the total analysed time. Desaturation severity is a sum of desaturation event areas normalized with total analysed time and obstruction severity parameter is a sum of the products of apnea and hypopnea durations and related desaturation areas normalized with total analysed time. The median follow-up time of the patients was 183?months (range 154-215?months). The 40 patients in each category were further divided into subgroups A and B with lowest and highest novel parameter values, respectively. AHI showed no differences between the subgroups. Mortality was increased in subgroups B compared to subgroups A. The correlation of the novel parameters with AHI was only moderate and the parameter values were partially overlapping between the AHI severity categories. This suggests that patients with similar AHI may in fact suffer from SAHS of very different severity. Thus, the present results suggest that the novel parameters could bring new insight to the individual estimation of the severity of SAHS.

Resumo Limpo

sleep apneahypopnea syndrom sah caus impair daytim function increas risk cardiovascular diseas apneahypopnea index ahi current use estim sever sah contain inform morpholog durat aspect breath cessat relat oxygen desatur longer breath cessat deeper desatur may sever consequ shorter shallow one address issu novel paramet contain inform durat morpholog breath cessat oxygen desatur calcul evalu male patient patient normal mild moder sever ahi sever categori obstruct desatur durat paramet consist sum event durat normal total analys time desatur sever sum desatur event area normal total analys time obstruct sever paramet sum product apnea hypopnea durat relat desatur area normal total analys time median followup time patient month rang month patient categori divid subgroup b lowest highest novel paramet valu respect ahi show differ subgroup mortal increas subgroup b compar subgroup correl novel paramet ahi moder paramet valu partial overlap ahi sever categori suggest patient similar ahi may fact suffer sah differ sever thus present result suggest novel paramet bring new insight individu estim sever sah

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