Med Biol Eng Comput - Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential.

Tópicos

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Resumo

Cardiac arrhythmias are initiated in regions that undergo cellular remodeling as a result of disease. Using a sub-cellular model of myocardium, we studied the mechanism of block caused by tissue microstructure remodeling: cell geometry [quantified as length/width (L/W) cell ratio] and cell-to-cell coupling (G(j)). Heterogeneities in cell L/W ratio and G ( j ) lead to block when excitability is reduced and the corresponding space constant (in the direction of propagation) increases by >40 %. Tissue architectures with elongated cells (i.e. large cell L/W ratios) that are better coupled (i.e. large G(j)) are less prone to block at sites of regional heterogeneities in cell geometry and/or cell coupling than tissue architectures consisting of cells with smaller L/W ratios and/or poorer coupling. Whether an increase in tissue anisotropic ratio (ANR) is arrhythmogenic or not depends on the cellular mechanism of the increase: ANR leads to an increased risk of block when G(j) decreases, but to a decreased risk of block when cell L/W ratio increases. Our findings are useful to understand the mechanisms of block in cardiac pathologies that result in tissue architecture remodeling.

Resumo Limpo

cardiac arrhythmia initi region undergo cellular remodel result diseas use subcellular model myocardium studi mechan block caus tissu microstructur remodel cell geometri quantifi lengthwidth lw cell ratio celltocel coupl gj heterogen cell lw ratio g j lead block excit reduc correspond space constant direct propag increas tissu architectur elong cell ie larg cell lw ratio better coupl ie larg gj less prone block site region heterogen cell geometri andor cell coupl tissu architectur consist cell smaller lw ratio andor poorer coupl whether increas tissu anisotrop ratio anr arrhythmogen depend cellular mechan increas anr lead increas risk block gj decreas decreas risk block cell lw ratio increas find use understand mechan block cardiac patholog result tissu architectur remodel

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