Med Biol Eng Comput - Non-invasive continuous glucose monitoring: improved accuracy of point and trend estimates of the Multisensor system.

Tópicos

{ estim(2440) model(1874) function(577) }
{ perform(999) metric(946) measur(919) }
{ howev(809) still(633) remain(590) }
{ monitor(1329) mobil(1314) devic(1160) }
{ featur(3375) classif(2383) classifi(1994) }
{ model(2341) predict(2261) use(1141) }
{ drug(1928) target(777) effect(648) }
{ method(1969) cluster(1462) data(1082) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ risk(3053) factor(974) diseas(938) }
{ patient(1821) servic(1111) care(1106) }
{ method(2212) result(1239) propos(1039) }
{ patient(2315) diseas(1263) diabet(1191) }
{ method(984) reconstruct(947) comput(926) }
{ age(1611) year(1155) adult(843) }
{ data(3008) multipl(1320) sourc(1022) }
{ can(774) often(719) complex(702) }
{ extract(1171) text(1153) clinic(932) }
{ data(1714) softwar(1251) tool(1186) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ compound(1573) activ(1297) structur(1058) }
{ blood(1257) pressur(1144) flow(957) }
{ model(3480) simul(1196) paramet(876) }
{ research(1218) medic(880) student(794) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ activ(1138) subject(705) human(624) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ use(1733) differ(960) four(931) }
{ imag(1947) propos(1133) code(1026) }
{ system(1976) rule(880) can(841) }
{ imag(2675) segment(2577) method(1081) }
{ take(945) account(800) differ(722) }
{ assess(1506) score(1403) qualiti(1306) }
{ clinic(1479) use(1117) guidelin(835) }
{ case(1353) use(1143) diagnosi(1136) }
{ import(1318) role(1303) understand(862) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ time(1939) patient(1703) rate(768) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ model(3404) distribut(989) bayesian(671) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ algorithm(1844) comput(1787) effici(935) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ visual(1396) interact(850) tool(830) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ use(2086) technolog(871) perceiv(783) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Non-invasive continuous glucose monitoring (NI-CGM) sensors are still at an early stage of development, but, in the near future, they could become particularly appealing in diabetes management. Solianis Monitoring AG (Zurich, Switzerland) has proposed an approach for NI-CGM based on a multi-sensor concept, embedding primarily dielectric spectroscopy and optical sensors. This concept requires a mathematical model able to estimate glucose levels from the 150 channels directly measured through the Multisensor. A static multivariate linear regression model (with order and parameters common to the entire population of subjects) was proposed for such a scope (Caduff et al., Biosens Bioelectron 26:3794-3800, 2011). The aim of this work is to evaluate the accuracy in the estimation of glucose levels and trends that the NI-CGM Multisensor platform can achieve by exploiting different techniques for model identification, namely, ordinary least squares, subset variable selection, partial least squares and least absolute shrinkage and selection operator (LASSO). Data collected in human beings monitored for a total of 45 study days were used for model identification and model test. Several metrics of standard use in the diabetes scientific community to measure point and clinical accuracy of glucose sensors were used to assess the models. Results indicate that the LASSO technique is superior to the others shrinking many channel weights to zero thus leading to smoother glucose profiles and resulting in a more robust model to possible artifacts in the Multisensor data. Although, as expected, the performance of the NI-CGM system with the LASSO model is not yet comparable with that of enzyme-based needle glucose sensors, glucose trends are satisfactorily estimated. Considering the non-invasive nature of the multi-sensor platform, this result can have an immediate impact in the current clinical practice, e.g., to integrate sparse self-monitoring of blood glucose data with an indication of the glucose trend to aid the diabetic patient in dealing with, or even preventing in the short time scale, the threats of critical events such as hypoglycaemia.

Resumo Limpo

noninvas continu glucos monitor nicgm sensor still earli stage develop near futur becom particular appeal diabet manag soliani monitor ag zurich switzerland propos approach nicgm base multisensor concept embed primarili dielectr spectroscopi optic sensor concept requir mathemat model abl estim glucos level channel direct measur multisensor static multivari linear regress model order paramet common entir popul subject propos scope caduff et al biosen bioelectron aim work evalu accuraci estim glucos level trend nicgm multisensor platform can achiev exploit differ techniqu model identif name ordinari least squar subset variabl select partial least squar least absolut shrinkag select oper lasso data collect human be monitor total studi day use model identif model test sever metric standard use diabet scientif communiti measur point clinic accuraci glucos sensor use assess model result indic lasso techniqu superior other shrink mani channel weight zero thus lead smoother glucos profil result robust model possibl artifact multisensor data although expect perform nicgm system lasso model yet compar enzymebas needl glucos sensor glucos trend satisfactorili estim consid noninvas natur multisensor platform result can immedi impact current clinic practic eg integr spars selfmonitor blood glucos data indic glucos trend aid diabet patient deal even prevent short time scale threat critic event hypoglycaemia

Resumos Similares

Lifetime Data Anal - Proportional hazards regression with interval censored data using an inverse probability weight. ( 0,826316230506525 )
Lifetime Data Anal - Predictive comparison of joint longitudinal-survival modeling: a case study illustrating competing approaches. ( 0,8043515350517 )
Lifetime Data Anal - A two-stage estimation in the Clayton-Oakes model with marginal linear transformation models for multivariate failure time data. ( 0,788140121473057 )
Med Decis Making - Eliciting benefit-risk preferences and probability-weighted utility using choice-format conjoint analysis. ( 0,784460918014845 )
Comput Math Methods Med - Application of seemingly unrelated regression in medical data with intermittently observed time-dependent covariates. ( 0,783605589569169 )
Lifetime Data Anal - Imputation for semiparametric transformation models with biased-sampling data. ( 0,781993988658953 )
Lifetime Data Anal - Profile local linear estimation of generalized semiparametric regression model for longitudinal data. ( 0,781871124392769 )
Lifetime Data Anal - Semiparametric additive marginal regression models for multiple type recurrent events. ( 0,778541058426331 )
Lifetime Data Anal - Regression analysis for cumulative incidence probability under competing risks and left-truncated sampling. ( 0,77640689403796 )
Lifetime Data Anal - Nonparametric estimation of the cumulative intensities in an interval censored competing risks model. ( 0,775604990677021 )
Lifetime Data Anal - A generalization of Turnbull's estimator for nonparametric estimation of the conditional survival function with interval-censored data. ( 0,775309746852327 )
Lifetime Data Anal - Simultaneous marginal survival estimators when doubly censored data is present. ( 0,774225253840135 )
Lifetime Data Anal - A hierarchical frailty model applied to two-generation melanoma data. ( 0,771584919820219 )
Res Synth Methods - Combining study outcome measures using dominance adjusted weights. ( 0,770599348247364 )
Lifetime Data Anal - Regression analysis based on conditional likelihood approach under semi-competing risks data. ( 0,768164917239352 )
Lifetime Data Anal - Estimating treatment effects on the marginal recurrent event mean in the presence of a terminating event. ( 0,765515240656341 )
Lifetime Data Anal - Nonparametric quasi-likelihood for right censored data. ( 0,764111094589437 )
Med Decis Making - Generalized additive models for the analysis of EQ-5D utility data. ( 0,762574253604718 )
Lifetime Data Anal - Estimation of treatment effects based on possibly misspecified Cox regression. ( 0,762471438907042 )
Lifetime Data Anal - Marginal semiparametric multivariate accelerated failure time model with generalized estimating equations. ( 0,7570267169555 )
Lifetime Data Anal - A pool-adjacent-violators type algorithm for non-parametric estimation of current status data with dependent censoring. ( 0,754797364308084 )
Med Decis Making - Underestimation of uncertainties in health utilities derived from mapping algorithms involving health-related quality-of-life measures: statistical explanations and potential remedies. ( 0,754661041677071 )
Med Decis Making - Regression estimators for generic health-related quality of life and quality-adjusted life years. ( 0,754137660862943 )
Res Synth Methods - Comparison of statistical inferences from the DerSimonian-Laird and alternative random-effects model meta-analyses - an empirical assessment of 920 Cochrane primary outcome meta-analyses. ( 0,753337370525886 )
Comput Methods Programs Biomed - Flexible multivariate marginal models for analyzing multivariate longitudinal data, with applications in R. ( 0,750267543965653 )
Lifetime Data Anal - Local linear estimation of concordance probability with application to covariate effects models on association for bivariate failure-time data. ( 0,748875696950603 )
Comput Methods Programs Biomed - mmm: an R package for analyzing multivariate longitudinal data with multivariate marginal models. ( 0,747472971600364 )
Lifetime Data Anal - Pseudo-observations for competing risks with covariate dependent censoring. ( 0,747289381794996 )
Comput Math Methods Med - Gray's time-varying coefficients model for posttransplant survival of pediatric liver transplant recipients with a diagnosis of cancer. ( 0,744623782145378 )
Neural Comput - Reliability of information-based integration of EEG and fMRI data: a simulation study. ( 0,743430275846174 )
Lifetime Data Anal - Semiparametric methods for center effect measures based on the ratio of survival functions. ( 0,741441441441441 )
J Chem Inf Model - A robust boosting regression tree with applications in quantitative structure-activity relationship studies of organic compounds. ( 0,739607698053196 )
Comput Methods Programs Biomed - A simulation procedure based on copulas to generate clustered multi-state survival data. ( 0,738780638155923 )
Lifetime Data Anal - Events per variable for risk differences and relative risks using pseudo-observations. ( 0,738709392669626 )
Comput Methods Programs Biomed - Model based period analysis of absolute and relative survival with R: data preparation, model fitting and derivation of survival estimates. ( 0,738266601498619 )
Neural Comput - Firing variability is higher than deduced from the empirical coefficient of variation. ( 0,737134734607061 )
Comput Methods Programs Biomed - Bayesian Decision Trees for predicting survival of patients: a study on the US National Trauma Data Bank. ( 0,736911250114365 )
Med Decis Making - Adjusting survival time estimates to account for treatment switching in randomized controlled trials--an economic evaluation context: methods, limitations, and recommendations. ( 0,736857534343229 )
Lifetime Data Anal - Additive-multiplicative rates model for recurrent events. ( 0,731705964665419 )
Med Decis Making - Calculating Utility Decrements Associated With an Adverse Event: Marginal Tobit and CLAD Coefficients Should Be Used With Caution. ( 0,729556416112667 )
Lifetime Data Anal - Estimation in a competing risks proportional hazards model under length-biased sampling with censoring. ( 0,728622028466092 )
Lifetime Data Anal - Likelihood ratio procedures and tests of fit in parametric and semiparametric copula models with censored data. ( 0,728188043817197 )
Lifetime Data Anal - Comparison of stopped Cox regression with direct methods such as pseudo-values and binomial regression. ( 0,727397224701159 )
Res Synth Methods - Robust variance estimation in meta-regression with dependent effect size estimates. ( 0,72621720340008 )
Comput Methods Programs Biomed - Poisson regression models outperform the geometrical model in estimating the peak-to-trough ratio of seasonal variation: a simulation study. ( 0,725992787199382 )
Lifetime Data Anal - On estimation of linear transformation models with nested case-control sampling. ( 0,725637996936769 )
Neural Comput - An estimation of generalized bradley-terry models based on the em algorithm. ( 0,7232986028032 )
Lifetime Data Anal - Computationally simple estimation and improved efficiency for special cases of double truncation. ( 0,722505196550212 )
Lifetime Data Anal - Statistical inference based on the nonparametric maximum likelihood estimator under double-truncation. ( 0,719883508134581 )
Neural Comput - ParceLiNGAM: a causal ordering method robust against latent confounders. ( 0,719815554083304 )
Lifetime Data Anal - Quantifying the average of the time-varying hazard ratio via a class of transformations. ( 0,71741095027538 )
Comput Methods Programs Biomed - A warning concerning the estimation of multinomial logistic models with correlated responses in SAS. ( 0,713964542797166 )
Lifetime Data Anal - Linear regression analysis of survival data with missing censoring indicators. ( 0,712096732952593 )
J Chem Inf Model - Estimation of environment-related properties of chemicals for design of sustainable processes: development of group-contribution+ (GC+) property models and uncertainty analysis. ( 0,706401338414976 )
Lifetime Data Anal - Robust methods to improve efficiency and reduce bias in estimating survival curves in randomized clinical trials. ( 0,70570557221025 )
J. Comput. Biol. - An optimization-based sampling scheme for phylogenetic trees. ( 0,705661877480233 )
Lifetime Data Anal - Evaluating hospital readmission rates in dialysis facilities; adjusting for hospital effects. ( 0,705534875463274 )
IEEE Trans Image Process - A tuned mesh-generation strategy for image representation based on data-dependent triangulation. ( 0,703549178390941 )
Lifetime Data Anal - Robust inference in discrete hazard models for randomized clinical trials. ( 0,700675589177233 )
Lifetime Data Anal - Cox regression for mixed case interval-censored data with covariate errors. ( 0,700184882221208 )
IEEE Trans Pattern Anal Mach Intell - Covariate Shift Adaptation for Discriminative 3D Pose Estimation. ( 0,69869066260742 )
Brief. Bioinformatics - Using cross-validation to evaluate predictive accuracy of survival risk classifiers based on high-dimensional data. ( 0,695428404390785 )
Comput Methods Programs Biomed - PSHREG: a SAS macro for proportional and nonproportional subdistribution hazards regression. ( 0,693845408889072 )
Res Synth Methods - Semiparametric hazard function estimation in meta-analysis for time to event data. ( 0,69337434844982 )
Lifetime Data Anal - Nonparametric estimation of current status data with dependent censoring. ( 0,691640133829865 )
Brief. Bioinformatics - On the validity of time-dependent AUC estimators. ( 0,689956082341437 )
Lifetime Data Anal - Semiparametric estimation of treatment effect with time-lagged response in the presence of informative censoring. ( 0,689817939724995 )
Lifetime Data Anal - The beta modified Weibull distribution. ( 0,686278243238273 )
Comput Methods Programs Biomed - Fitting semiparametric regressions for panel count survival data with an R package spef. ( 0,685680924609533 )
Lifetime Data Anal - A functional inference for multivariate current status data with mismeasured covariate. ( 0,684720950794929 )
Lifetime Data Anal - Estimation of odds of concordance based on the Aalen additive model. ( 0,683619746940788 )
Lifetime Data Anal - Regression analysis of informative current status data with the additive hazards model. ( 0,681613905424548 )
Lifetime Data Anal - Nonparametric estimation with recurrent competing risks data. ( 0,681281617664736 )
Res Synth Methods - Meta-analysis of time-to-event data: a comparison of two-stage methods. ( 0,679064087954886 )
Methods Inf Med - Regularization for generalized additive mixed models by likelihood-based boosting. ( 0,678613316804877 )
Comput Methods Programs Biomed - Weighted comparison of two cumulative incidence functions with R-CIFsmry package. ( 0,678003965236839 )
Res Synth Methods - Robust variance estimation with dependent effect sizes: practical considerations including a software tutorial in Stata and spss. ( 0,676110425245246 )
Comput Math Methods Med - A new ratio for protocol categorization. ( 0,675121742413685 )
Lifetime Data Anal - Non-crossing weighted kernel quantile regression with right censored data. ( 0,67391235451301 )
Comput Math Methods Med - A gradient boosting algorithm for survival analysis via direct optimization of concordance index. ( 0,67266105857928 )
Neural Comput - On quadrature methods for refractory point process likelihoods. ( 0,672415039789962 )
Neural Comput - Least squares estimation without priors or supervision. ( 0,670736509930579 )
IEEE Trans Image Process - Maximum likelihood orientation estimation of 1-D patterns in Laguerre-Gauss subspaces. ( 0,670250433353385 )
Lifetime Data Anal - Proportional hazards regression in the presence of missing study eligibility information. ( 0,669913182234409 )
Lifetime Data Anal - Maximum likelihood analysis of semicompeting risks data with semiparametric regression models. ( 0,669539329138668 )
Lifetime Data Anal - Censored quantile regression for residual lifetimes. ( 0,669259503423517 )
Lifetime Data Anal - Models and estimation for systems with recurrent events and usage processes. ( 0,66808086810808 )
Lifetime Data Anal - Competing risks with missing covariates: effect of haplotypematch on hematopoietic cell transplant patients. ( 0,667409282479809 )
Lifetime Data Anal - Estimation of cumulative incidence functions when the lifetime distributions are uniformly stochastically ordered. ( 0,666187669305838 )
IEEE Trans Pattern Anal Mach Intell - Learning Graphical Model Parameters with Approximate Marginal Inference. ( 0,664913068604134 )
J. Comput. Biol. - Improved harmonic mean estimator for phylogenetic model evidence. ( 0,664427991349472 )
Lifetime Data Anal - A proportional hazards regression model with change-points in the baseline function. ( 0,662789586750548 )
Lifetime Data Anal - Semiparametric analysis of recurrent events: artificial censoring, truncation, pairwise estimation and inference. ( 0,661510210823938 )
Neural Comput - Nonparametric estimation of K?llback-Leibler divergence. ( 0,660694236403553 )
Lifetime Data Anal - Applying competing risks regression models: an overview. ( 0,660439420270243 )
Lifetime Data Anal - Matched survival data in a co-twin control design. ( 0,658942104057541 )
Lifetime Data Anal - Marginal hazard regression for correlated failure time data with auxiliary covariates. ( 0,656629620165369 )
Lifetime Data Anal - A general joint model for longitudinal measurements and competing risks survival data with heterogeneous random effects. ( 0,656203950119177 )
Comput Methods Programs Biomed - The Lindley distribution applied to competing risks lifetime data. ( 0,653452635969045 )
Med Biol Eng Comput - Clinical applications of musculoskeletal modelling for the shoulder and upper limb. ( 0,652045602363154 )