Med Biol Eng Comput - Numerical study of nanofluid infusion in deformable tissues for hyperthermia cancer treatments.


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Direct infusion by means of needles is one of the widely used methods for the delivery of nanoparticles in tumors for hyperthermia cancer treatments. During an infusion process, infusion-induced deformation can substantially affect the dispersion of the nanoparticles injected in a biological tissue. In this study, a poroelastic model is developed to investigate fluid transport and flow-induced tissue deformation in a tumor during an infusion process. A surface tracking technique is employed to predict the shape of nanofluid spreading after injection. The model is then used to simulate the formation of backflow and the change of tissue porosity due to the deformation. Specifically, we quantify the influence of the backflow on the spreading shape of the nanofluid and its dependence on injection parameters such as infusion rates, needle diameters, and tumor elastic properties. It is found that backflow is an important factor causing an irregular distribution of the nanofluid injected in a tumor. A higher infusion rate, larger needle diameter, and lower elastic modulus yield a longer backflow length and cause a more irregular spreading shape of the nanofluid. The infusion-induced tissue deformation also leads to a pore swelling and an increase of the porosity in the vicinity of the needle tip and the needle outer surface. It is anticipated that the increased pore size may facilitate the particle penetration in a tumor. To achieve a controlled heat generation, the injection parameters should be selected judiciously with the consideration of tumor sizes, tumor properties, and thresholds at which tumors break under the infusion pressure.

Resumo Limpo

direct infus mean needl one wide use method deliveri nanoparticl tumor hyperthermia cancer treatment infus process infusioninduc deform can substanti affect dispers nanoparticl inject biolog tissu studi poroelast model develop investig fluid transport flowinduc tissu deform tumor infus process surfac track techniqu employ predict shape nanofluid spread inject model use simul format backflow chang tissu poros due deform specif quantifi influenc backflow spread shape nanofluid depend inject paramet infus rate needl diamet tumor elast properti found backflow import factor caus irregular distribut nanofluid inject tumor higher infus rate larger needl diamet lower elast modulus yield longer backflow length caus irregular spread shape nanofluid infusioninduc tissu deform also lead pore swell increas poros vicin needl tip needl outer surfac anticip increas pore size may facilit particl penetr tumor achiev control heat generat inject paramet select judici consider tumor size tumor properti threshold tumor break infus pressur

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