Med Biol Eng Comput - The effects of nicotine exposure and PFC transection on the time-frequency distribution of VTA DA neurons' firing activities.

Tópicos

{ network(2748) neural(1063) input(814) }
{ chang(1828) time(1643) increas(1301) }
{ activ(1138) subject(705) human(624) }
{ spatial(1525) area(1432) region(1030) }
{ signal(2180) analysi(812) frequenc(800) }
{ system(1976) rule(880) can(841) }
{ bind(1733) structur(1185) ligand(1036) }
{ group(2977) signific(1463) compar(1072) }
{ studi(1410) differ(1259) use(1210) }
{ studi(1119) effect(1106) posit(819) }
{ import(1318) role(1303) understand(862) }
{ intervent(3218) particip(2042) group(1664) }
{ imag(1947) propos(1133) code(1026) }
{ method(1219) similar(1157) match(930) }
{ error(1145) method(1030) estim(1020) }
{ method(1557) propos(1049) approach(1037) }
{ monitor(1329) mobil(1314) devic(1160) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ algorithm(1844) comput(1787) effici(935) }
{ general(901) number(790) one(736) }
{ sampl(1606) size(1419) use(1276) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

We investigated the influence of nicotine exposure and prefrontal cortex (PFC) transections on ventral tegmental areas (VTA) dopamine (DA) neurons' firing activities using a time-frequency method based on the continuous wavelet transform (CWT). Extracellular single-unit neural activity was recorded from DA neurons in the VTA area of rats. One group had their PFC inputs to the VTA intact, while the other group had the inputs to VTA bilaterally transected immediate caudal to the PFC. We hypothesized that the systemic nicotine exposure will significantly change the energy distribution in the recorded neural activity. Additionally, we investigated whether the loss of inputs to the VTA caused by the PFC transection resulted in the cancellation of the nicotine' effect on the neurons' firing patterns. The time-frequency representations of VTA DA neurons firing activity were estimated from the reconstructed firing rate histogram. The energy contents were estimated from three frequency bands, which are known to encompass the significant modes of operation of DA neurons. Our results show that systemic nicotine exposure disrupts the energy distribution in PFC-intact rats. Particularly, there is a significant increase in energy contents of the 1-1.5?Hz frequency band. This corresponds to an observed increase in the firing rate of VTA DA neurons following nicotine exposure. Additionally, our results from PFC-transected rats show that there is no change in the energy distribution of the recordings after systemic nicotine exposure. These results indicate that the PFC plays an important role in affecting the activities of VTA DA neurons and that the CWT is a useful method for monitoring the changes in neural activity patterns in both time and frequency domains.

Resumo Limpo

investig influenc nicotin exposur prefront cortex pfc transect ventral tegment area vta dopamin da neuron fire activ use timefrequ method base continu wavelet transform cwt extracellular singleunit neural activ record da neuron vta area rat one group pfc input vta intact group input vta bilater transect immedi caudal pfc hypothes system nicotin exposur will signific chang energi distribut record neural activ addit investig whether loss input vta caus pfc transect result cancel nicotin effect neuron fire pattern timefrequ represent vta da neuron fire activ estim reconstruct fire rate histogram energi content estim three frequenc band known encompass signific mode oper da neuron result show system nicotin exposur disrupt energi distribut pfcintact rat particular signific increas energi content hz frequenc band correspond observ increas fire rate vta da neuron follow nicotin exposur addit result pfctransect rat show chang energi distribut record system nicotin exposur result indic pfc play import role affect activ vta da neuron cwt use method monitor chang neural activ pattern time frequenc domain

Resumos Similares

Neural Comput - Learning rule of homeostatic synaptic scaling: presynaptic dependent or not. ( 0,727624666530642 )
Comput Math Methods Med - Investigation of innervation zone shift with continuous dynamic muscle contraction. ( 0,721972479803438 )
Med Biol Eng Comput - Higuchi's fractal dimension for analysis of the effect of external periodic stressor on electrical oscillations in the brain. ( 0,70797492980225 )
Comput Methods Programs Biomed - Direct effects of audio-visual stimulation on EEG. ( 0,705302443943841 )
Neural Comput - Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity. ( 0,687796487953036 )
Int J Neural Syst - Transcranial magnetic stimulation (TMS) modulates epileptiform discharges in patients with frontal lobe epilepsy: a preliminary EEG-TMS study. ( 0,672780212750905 )
Neural Comput - How the brain generates movement. ( 0,668399295862985 )
Neural Comput - Computer modeling of mild axonal injury: implications for axonal signal transmission. ( 0,642978050725599 )
Comput Math Methods Med - Neuroelectrical correlates of trustworthiness and dominance judgments related to the observation of political candidates. ( 0,628323614103852 )
Med Biol Eng Comput - Neural oscillators triggered by loading and hip orientation can generate activation patterns at the ankle during walking in humans. ( 0,619704804523023 )
Neural Comput - Anatomical constraints on lateral competition in columnar cortical architectures. ( 0,612042062641974 )
Neural Comput - Subdiffusive dynamics of bump attractors: mechanisms and functional roles. ( 0,609413596700386 )
Comput Math Methods Med - Altered intrinsic connectivity networks in frontal lobe epilepsy: a resting-state fMRI study. ( 0,60643057856186 )
Neural Comput - Enhanced stimulus encoding capabilities with spectral selectivity in inhibitory circuits by STDP. ( 0,58878416394863 )
Comput Math Methods Med - Voxel scale complex networks of functional connectivity in the rat brain: neurochemical state dependence of global and local topological properties. ( 0,587101144136917 )
Int J Neural Syst - A new work mechanism on neuronal activity. ( 0,586954302574856 )
Comput. Biol. Med. - Role of intracellular calcium dynamics in the short-term memory in CVM model: a simulation study. ( 0,585400856128086 )
Comput Methods Programs Biomed - Characterizing electrical signals evoked by acupuncture through complex network mapping: a new perspective on acupuncture. ( 0,584145804604372 )
Int J Neural Syst - Effects of extremely low-frequency magnetic fields on the response of a conductance-based neuron model. ( 0,580132158329158 )
IEEE Trans Image Process - Toward a direct measure of video quality perception using EEG. ( 0,576404612124986 )
Comput Methods Programs Biomed - A simulation of T-wave alternans vectocardiographic representation performed by changing the ventricular heart cells action potential duration. ( 0,575239292215859 )
Neural Comput - Rewiring-induced chaos in pulse-coupled neural networks. ( 0,571071178594816 )
Med Biol Eng Comput - Effects of muscle fibre shortening on the characteristics of surface motor unit potentials. ( 0,570450881528363 )
Med Biol Eng Comput - An EEG-based real-time cortical functional connectivity imaging system. ( 0,57032364385817 )
Comput. Biol. Med. - Deep and surface hemodynamic signal from functional time resolved transcranial near infrared spectroscopy compared to skin flowmotion. ( 0,569175651620067 )
J Med Syst - Analysis of repetitive flash stimulation frequencies and record periods to detect migraine using artificial neural network. ( 0,567953878024964 )
Comput Math Methods Med - Multiscale cross-approximate entropy analysis as a measure of complexity among the aged and diabetic. ( 0,565310151025307 )
Neural Comput - Internal-time temporal difference model for neural value-based decision making. ( 0,564539865626627 )
Med Biol Eng Comput - Peculiarities of extracellular potentials produced by deep muscles. Part 2: motor unit potentials. ( 0,563408321720223 )
Neural Comput - Spontaneous slow oscillations and sequential patterns due to short-term plasticity in a model of the cortex. ( 0,562443799179822 )
Comput Math Methods Med - Dynamic variability of isometric action tremor in precision pinching. ( 0,560365866468523 )
Neural Comput - Predicting single-neuron activity in locally connected networks. ( 0,558394014143262 )
Int J Neural Syst - Perceptual suppression revealed by adaptive multi-scale entropy analysis of local field potential in monkey visual cortex. ( 0,557589996015228 )
Med Biol Eng Comput - Optical monitoring of neural networks evoked by focal electrical stimulation on microelectrode arrays using FM dyes. ( 0,557455202254861 )
Comput Math Methods Med - Weighted phase lag index and graph analysis: preliminary investigation of functional connectivity during resting state in children. ( 0,557407774710673 )
Med Biol Eng Comput - A novel method for recording neuronal depolarization with recording at 125-825?Hz: implications for imaging fast neural activity in the brain with electrical impedance tomography. ( 0,556711951219628 )
Neural Comput - Synaptic scaling stabilizes persistent activity driven by asynchronous neurotransmitter release. ( 0,555193435160785 )
J Clin Monit Comput - Increases in voltage may produce false-negatives when using transcranial motor evoked potentials to detect an isolated nerve root injury. ( 0,553863781852577 )
Neural Comput - Kernel current source density method. ( 0,552332699811048 )
Med Biol Eng Comput - Spectral EEG frontal asymmetries correlate with the experienced pleasantness of TV commercial advertisements. ( 0,551682113454116 )
Int J Neural Syst - Adaptation-dependent synchronization transitions and burst generations in electrically coupled neural networks. ( 0,549930191369688 )
Comput. Biol. Med. - Anatomic and electro-physiologic connectivity of the language system: a combined DTI-CCEP study. ( 0,549824079714543 )
Int J Neural Syst - Drug polyconsumption is associated with increased synchronization of brain electrical-activity at rest and in a counting task. ( 0,544895129314033 )
Med Biol Eng Comput - Sensorimotor cortical response during motion reflecting audiovisual stimulation: evidence from fractal EEG analysis. ( 0,543280058632338 )
Comput. Biol. Med. - Connectivity analysis of multichannel EEG signals using recurrence based phase synchronization technique. ( 0,543098804488688 )
Int J Neural Syst - A neuron-based time-optimal controller of horizontal saccadic eye movements. ( 0,542379944075025 )
Comput Math Methods Med - Inferring functional neural connectivity with phase synchronization analysis: a review of methodology. ( 0,541913664588198 )
IEEE Trans Neural Netw Learn Syst - Phase Oscillatory Network and Visual Pattern Recognition. ( 0,541625060545555 )
Neural Comput - Design of charge-balanced time-optimal stimuli for spiking neuron oscillators. ( 0,538393794988264 )
Spat Spatiotemporal Epidemiol - Statistical power of disease cluster and clustering tests for rare diseases: a simulation study of point sources. ( 0,537712614758188 )
Comput Biol Chem - Mapping the intramolecular signal propagation pathways in protein using Bayesian change point analysis of atomic motions. ( 0,534952526544047 )
J Chem Inf Model - Modeling the interface between islet amyloid polypeptide and insulin-based aggregation inhibitors: correlation to aggregation kinetics and membrane damage. ( 0,530497371996375 )
Comput Methods Programs Biomed - Introducing treatment strategy for cerebellar ataxia in mutant med mice: combination of acetazolamide and 4-aminopyridine. ( 0,529648020505189 )
Neural Comput - Subthreshold membrane depolarization as memory trace for perceptual learning. ( 0,528929365248795 )
Methods Inf Med - Auditory and Nociceptive Stimuli Responses in the Electroencephalogram. A Non-linear Measures and Time-frequency Representation Based Analysis. ( 0,528566783465686 )
Neural Comput - Noise tolerance of attractor and feedforward memory models. ( 0,525105031510504 )
Neural Comput - Facilitation of neuronal responses by intrinsic default mode network activity. ( 0,524542193551767 )
Neural Comput - Dynamical synapses enhance neural information processing: gracefulness, accuracy, and mobility. ( 0,524453676403607 )
Neural Comput - Complete classification of the macroscopic behavior of a heterogeneous network of theta neurons. ( 0,523697458400839 )
Neural Comput - A bayesian model of polychronicity. ( 0,52244085257993 )
Neural Comput - The competing benefits of noise and heterogeneity in neural coding. ( 0,521612812996019 )
Neural Comput - Dissociable forms of repetition priming: a computational model. ( 0,5188345686541 )
J Chem Inf Model - Molecular dynamics perspective on the protein thermal stability: a case study using SAICAR synthetase. ( 0,518811277955104 )
Comput Math Methods Med - Concentration-invariant odor representation in the olfactory system by presynaptic inhibition. ( 0,51842580821893 )
Neural Comput - Traveling bumps and their collisions in a two-dimensional neural field. ( 0,51707295194366 )
IEEE J Biomed Health Inform - Analysis of the EMG Signal During Cyclic Movements Using Multicomponent AM-FM Decomposition. ( 0,51685171282372 )
Comput. Biol. Med. - Extracting biomarkers of autism from MEG resting-state functional connectivity networks. ( 0,516691850387862 )
J Med Syst - Control of sevoflurane anesthetic agent via neural network using electroencephalogram signals during anesthesia. ( 0,516532170590805 )
Neural Comput - Replicating receptive fields of simple and complex cells in primary visual cortex in a neuronal network model with temporal and population sparseness and reliability. ( 0,516440925902009 )
Neural Comput - Fragility in dynamic networks: application to neural networks in the epileptic cortex. ( 0,516409717079138 )
Comput Math Methods Med - Enhancing the signal of corticomuscular coherence. ( 0,515889444864687 )
Methods Inf Med - Surface and intramural reentrant patterns during atrial fibrillation in the sheep. ( 0,51551002998637 )
Int J Neural Syst - Relationship between applicability of current-based synapses and uniformity of firing patterns. ( 0,515352712424318 )
Neural Comput - Interactions of excitatory and inhibitory feedback topologies in facilitating pattern separation and retrieval. ( 0,515004642967166 )
Neural Comput - On the continuous differentiability of inter-spike intervals of synaptically connected cortical spiking neurons in a neuronal network. ( 0,514442226243027 )
J Med Syst - The effect of an auxiliary stimulation on motor function restoration by FES. ( 0,512997828538463 )
Med Biol Eng Comput - The effect of precordial lead displacement on ECG morphology. ( 0,511424352934064 )
Neural Comput - Exact event-driven implementation for recurrent networks of stochastic perfect integrate-and-fire neurons. ( 0,510988586015738 )
Med Biol Eng Comput - Self-mixing microprobe for monitoring microvascular perfusion in rat brain. ( 0,51017327500131 )
Neural Comput - Intrinsic adaptation in autonomous recurrent neural networks. ( 0,50964123890903 )
Neural Comput - Mechanisms that modulate the transfer of spiking correlations. ( 0,509502624258376 )
Neural Comput - Analysis of the stabilized supralinear network. ( 0,509367106331746 )
Comput Math Methods Med - A DAQ-device-based continuous wave near-infrared spectroscopy system for measuring human functional brain activity. ( 0,508937533431485 )
Neural Comput - Self-organization of topographic bilinear networks for invariant recognition. ( 0,508651339828831 )
IEEE Trans Neural Netw Learn Syst - Stability Analysis of Distributed Delay Neural Networks Based on Relaxed Lyapunov-Krasovskii Functionals. ( 0,508650812788743 )
Neural Comput - Echo state property linked to an input: exploring a fundamental characteristic of recurrent neural networks. ( 0,507233480388733 )
IEEE J Biomed Health Inform - Analysis of the Chaotic Characteristics of Human Colonic Activities and Comparison of Healthy Participants to Costive Subjects. ( 0,506311605790926 )
J Med Syst - Determining the appropriate amount of anesthetic gas using DWT and EMD combined with neural network. ( 0,505891624024385 )
Comput Math Methods Med - Detection of structural changes in tachogram series for the diagnosis of atrial fibrillation events. ( 0,505523310314756 )
J Chem Inf Model - Molecular dynamics simulations of a hyperthermophilic and a mesophilic protein L30e. ( 0,504936126316339 )
Neural Comput - Computing with a canonical neural circuits model with pool normalization and modulating feedback. ( 0,504474340158599 )
Int J Neural Syst - Real-time EEG-based detection of fatigue driving danger for accident prediction. ( 0,503810367455778 )
Comput Methods Programs Biomed - Numerical investigation of white matter anisotropic conductivity in defining current distribution under tDCS. ( 0,503130582391281 )
Comput. Biol. Med. - EEG-based functional networks in schizophrenia. ( 0,502450865430587 )
Neural Comput - Statistical computer model analysis of the reciprocal and recurrent inhibitions of the Ia-EPSP in a-motoneurons. ( 0,502247071833265 )
J Med Syst - Classification of arrhythmia using hybrid networks. ( 0,50074326682127 )
J Chem Inf Model - Differential binding of latrunculins to G-actin: a molecular dynamics study. ( 0,500417014250971 )
Comput Math Methods Med - Characteristics of evoked potential multiple EEG recordings in patients with chronic pain by means of parallel factor analysis. ( 0,498741932181057 )
Methods Inf Med - Connectivity analysis of somatosensory evoked potentials in patients with major depression. Analysis of connectivity. ( 0,498029462054763 )
Neural Comput - Short-term memory capacity in networks via the restricted isometry property. ( 0,49715136109013 )