Med Biol Eng Comput - Analysis of cell membrane permeabilization mechanics and pore shape due to ultrashort electrical pulsing.

Tópicos

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Resumo

Cell membrane permeabilization mechanics and the resulting shape of nanopores in response to electrical pulsing are probed based on a continuum approach. This has implications for electropermeabilization and cell membrane transport. It is argued that small pores resulting from high-intensity (approximately 100 kV/cm), nanosecond pulsing would have an initial asymmetric shape. This would lead to asymmetric membrane current-voltage characteristics, at least at early times. The role of the cytoskeleton is ignored here, but can be expected to additionally contribute to such asymmetries. Furthermore, we show that the pore shape and membrane conduction would be dynamic, and evolve toward a symmetric characteristic over time. This duration has been shown to be in the micro-second range.

Resumo Limpo

cell membran permeabil mechan result shape nanopor respons electr puls probe base continuum approach implic electropermeabil cell membran transport argu small pore result highintens approxim kvcm nanosecond puls initi asymmetr shape lead asymmetr membran currentvoltag characterist least earli time role cytoskeleton ignor can expect addit contribut asymmetri furthermor show pore shape membran conduct dynam evolv toward symmetr characterist time durat shown microsecond rang

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