Med Biol Eng Comput - Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling.


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The ability of using non-expensive ultrasound (US) image data together with computer fluid simulation to access various severities of carotid stenosis was inquired in this study. Subject-specific hemodynamic conditions were simulated using a developed finite element solver. Individual structured meshing of the common carotid artery (CCA) bifurcation was built from segmented longitudinal and cross-sectional US images; imposed boundary velocities were based on Doppler US measurements. Simulated hemodynamic parameters such as velocities, wall shear stress (WSS) and derived descriptors were able to predict disturbed flow conditions which play an important role in the development of local atherosclerotic plaques. Hemodynamic features from six individual CCA bifurcations were analyzed. High values of time-averaged WSS (TAWSS) were found at stenosis site. Low values of TAWSS were found at the bulb and at the carotid internal and external branches depending on the particular features of each patient. High oscillating shear index and relative residence time values assigned highly disturbed flows at the same artery surface regions that correlate only moderately with low TAWSS results. Based on clinic US examinations, results provide estimates of flow changes and forces at the carotid artery wall toward the link between hemodynamic behavior and stenosis pathophysiology.

Resumo Limpo

abil use nonexpens ultrasound us imag data togeth comput fluid simul access various sever carotid stenosi inquir studi subjectspecif hemodynam condit simul use develop finit element solver individu structur mesh common carotid arteri cca bifurc built segment longitudin crosssect us imag impos boundari veloc base doppler us measur simul hemodynam paramet veloc wall shear stress wss deriv descriptor abl predict disturb flow condit play import role develop local atherosclerot plaqu hemodynam featur six individu cca bifurc analyz high valu timeaverag wss tawss found stenosi site low valu tawss found bulb carotid intern extern branch depend particular featur patient high oscil shear index relat resid time valu assign high disturb flow arteri surfac region correl moder low tawss result base clinic us examin result provid estim flow chang forc carotid arteri wall toward link hemodynam behavior stenosi pathophysiolog

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