Med Biol Eng Comput - Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo.

Tópicos

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Resumo

We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40?MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different scales. Further, we have extended the field of view of our imaging system to entire bodies of small animals. At different imaging planes, we have noninvasively imaged the major blood vessels (e.g., descending aorta, intercostal vessels, cephalic vessels, brachial vessels, femoral vessels, popliteal vessels, lateral marginal vessels, cranial mesenteric vessels, mammalian vessels, carotid artery, jugular vein, subclavian vessels, iliac vessels, and caudal vessels) as well as intact internal organs (e.g., spleen, liver, kidney, intestine, cecum, and spinal cord) of the animals in vivo. The spectroscopic whole-body photoacoustic imaging clearly reveals the spectral responses of the internal structures. Similar to other existing preclinical whole-body imaging systems, this whole-body photoacoustic tomography can be a useful tool for small-animal research.

Resumo Limpo

success develop multiscal acousticresolut photoacoust tomographi system singl imag platform switch ultrasound transduc center frequenc mhz optic condens photoacoust imag microvasculatur small anim vivo differ scale extend field view imag system entir bodi small anim differ imag plane noninvas imag major blood vessel eg descend aorta intercost vessel cephal vessel brachial vessel femor vessel poplit vessel later margin vessel cranial mesenter vessel mammalian vessel carotid arteri jugular vein subclavian vessel iliac vessel caudal vessel well intact intern organ eg spleen liver kidney intestin cecum spinal cord anim vivo spectroscop wholebodi photoacoust imag clear reveal spectral respons intern structur similar exist preclin wholebodi imag system wholebodi photoacoust tomographi can use tool smallanim research

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