Med Biol Eng Comput - Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics.

Tópicos

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Resumo

A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97?% of BAVs include asymmetric cusps, little or no prior studies have investigated the blood flow through a three-dimensional BAV and root. The aim of the present study was to characterize the effect of asymmetric BAV on the blood flow using fully coupled fluid-structure interaction (FSI) models with improved boundary conditions and tissue properties. This study presents four FSI models, including a native TAV, asymmetric BAVs with or without a raphe, and an almost symmetric BAV. Cusp tissue is composed of hyperelastic finite elements with collagen fibres embedded in the elastin matrix. A full cardiac cycle is simulated by imposing the same physiological blood pressures for all the TAV and BAV models. The latter have significantly smaller opening areas compared with the TAV. Larger stress values were found in the cusps of BAVs with fused cusps, at both the systolic and diastolic phases. The asymmetric geometry caused asymmetric vortices and much larger flow shear stress on the cusps which could be a potential initiator for early valvular calcification of BAVs.

Resumo Limpo

bicuspid aortic valv bav congenit cardiac disord valv consist two cusp instead three normal tricuspid valv tav although bav includ asymmetr cusp littl prior studi investig blood flow threedimension bav root aim present studi character effect asymmetr bav blood flow use fulli coupl fluidstructur interact fsi model improv boundari condit tissu properti studi present four fsi model includ nativ tav asymmetr bav without raph almost symmetr bav cusp tissu compos hyperelast finit element collagen fibr embed elastin matrix full cardiac cycl simul impos physiolog blood pressur tav bav model latter signific smaller open area compar tav larger stress valu found cusp bav fuse cusp systol diastol phase asymmetr geometri caus asymmetr vortic much larger flow shear stress cusp potenti initi earli valvular calcif bav

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