Med Biol Eng Comput - In vitro electroretinogram for the study of the functionality of differentiated retinal pigment epithelium cells.

Tópicos

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Resumo

The purpose of this study is to develop and test a method to reveal if the retinal pigment epithelium (RPE) cells differentiated from human embryonic stem cells (hESC) support the functions of photoreceptors. hESC-derived RPE (hESC-RPE) cells offer a potent cell source for cell replacement therapy that may be used to prevent certain eye diseases. Methods to assure the functionality of the RPE cells are well warranted. Electroretinograms (ERG) measure the electrophysiological response of the retina to light stimuli. A setup was developed that enables the measurement of ERG in vitro from mice retinas cultured together with hESC-RPE cells. The co-culture of RPE and retinas seems to be a viable tool to assess the functionality of RPE in vitro. However, owing to limited sample size results were somewhat mixed, and thus it was not possible to prove that hESC-RPE cells enhance the ERG response of a mouse retina in vitro. The long-term culturing of the retinas needs to be refined to acquire more conclusive evidence of the supporting role of the RPE and to explore the full potential of the co-culture and ERG methods in assessing RPE functionality.

Resumo Limpo

purpos studi develop test method reveal retin pigment epithelium rpe cell differenti human embryon stem cell hesc support function photoreceptor hescderiv rpe hescrp cell offer potent cell sourc cell replac therapi may use prevent certain eye diseas method assur function rpe cell well warrant electroretinogram erg measur electrophysiolog respons retina light stimuli setup develop enabl measur erg vitro mice retina cultur togeth hescrp cell cocultur rpe retina seem viabl tool assess function rpe vitro howev owe limit sampl size result somewhat mix thus possibl prove hescrp cell enhanc erg respons mous retina vitro longterm cultur retina need refin acquir conclus evid support role rpe explor full potenti cocultur erg method assess rpe function

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