Med Biol Eng Comput - Determination of electrode to nerve fiber distance and nerve conduction velocity through spectral analysis of the extracellular action potentials recorded from earthworm giant fibers.

Tópicos

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Resumo

Microneurography and the use of selective microelectrodes that can resolve single-unit nerve activity have become a tool to understand the coding within the nervous system and a clinical diagnostic tool to assess peripheral neural pathologies. Central to these techniques is the use of the differences in the shape of the extracellular action potential (AP) waveform to identify and discriminate units from one another. Theoretical modeling of the origins of these shape differences has shown that the position of the nerve fiber relative to the electrode and the conduction velocity of the unit contribute to these differences giving rise to the hypothesis that more information about the fiber and its relationship to the electrode could be extracted given further analysis of the AP waveform. This paper addresses this question by exploring the electrical coupling between the electrode and nerve fiber. Idealized models and the literature indicate that two parameters, the electrode-fiber distance and the unit conduction velocity, contribute to the amplitude of the extracellular AP detected by the electrode, which confounds the quantification of coupling using the spike amplitude alone. To resolve this, we develop a method that enables differential quantification of these two parameters using spectral analysis of the single-unit AP waveform and demonstrate that the two parameters could be effectively decoupled in an in vitro earthworm model. The method could open the way forward toward micro-scale in situ monitoring of the interaction of nerve fiber and neural interface.

Resumo Limpo

microneurographi use select microelectrod can resolv singleunit nerv activ becom tool understand code within nervous system clinic diagnost tool assess peripher neural patholog central techniqu use differ shape extracellular action potenti ap waveform identifi discrimin unit one anoth theoret model origin shape differ shown posit nerv fiber relat electrod conduct veloc unit contribut differ give rise hypothesi inform fiber relationship electrod extract given analysi ap waveform paper address question explor electr coupl electrod nerv fiber ideal model literatur indic two paramet electrodefib distanc unit conduct veloc contribut amplitud extracellular ap detect electrod confound quantif coupl use spike amplitud alon resolv develop method enabl differenti quantif two paramet use spectral analysi singleunit ap waveform demonstr two paramet effect decoupl vitro earthworm model method open way forward toward microscal situ monitor interact nerv fiber neural interfac

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