Med Biol Eng Comput - Haemodynamic forces on in vitro thrombi: a numerical analysis.

Tópicos

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Resumo

The flow of blood past an axisymmetric thrombus analogue, within an in vitro geometry, is computed via solution of the discrete three-dimensional (3D) Navier-Stokes equations. Particle tracking is used to model the behaviour of thrombocytes (platelets) moving throughout the domain and to investigate behaviour with respect to the platelets. The system is explored using shear rate to quantify the effects an idealised thrombus has with respect to an undisturbed in vitro geometry over 'Poiseuille flow' shear rate conditions applicable to in vivo and in vitro experiments (1,200-10,000 s?). Local shear rate variations show peaks in shear rate greater than double that of Poiseuille flow conditions. These local shear rate variations are observed to be non-linear, despite the low Reynolds number (5.2-43.4) within the system. Topological transitions of shear rate are observed, limiting the height of peak shear rate within the system, suggesting a thrombus growth limiting behaviour. Temporal gradients of shear rate, measured with respect to individual platelets, were calculated. Multiple regions of peak shear rate gradient were observed throughout the flow, suggesting that platelet-platelet interaction may not be limited to regions near to the surface of the thrombus.

Resumo Limpo

flow blood past axisymmetr thrombus analogu within vitro geometri comput via solut discret threedimension d navierstok equat particl track use model behaviour thrombocyt platelet move throughout domain investig behaviour respect platelet system explor use shear rate quantifi effect idealis thrombus respect undisturb vitro geometri poiseuill flow shear rate condit applic vivo vitro experi s local shear rate variat show peak shear rate greater doubl poiseuill flow condit local shear rate variat observ nonlinear despit low reynold number within system topolog transit shear rate observ limit height peak shear rate within system suggest thrombus growth limit behaviour tempor gradient shear rate measur respect individu platelet calcul multipl region peak shear rate gradient observ throughout flow suggest plateletplatelet interact may limit region near surfac thrombus

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