Med Biol Eng Comput - Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study.

Tópicos

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Resumo

Thin-walled cardiac tissue samples superfused with oxygenated solutions are widely used in experimental studies. However, due to decreased oxygen supply and insufficient wash out of waste products in the inner layers of such preparations, electrophysiological functions could be compromised. Although the cascade of events triggered by cutting off perfusion is well known, it remains unclear as to which degree electrophysiological function in viable surface layers is affected by pathological processes occurring in adjacent tissue. Using a 3D numerical bidomain model, we aim to quantify the impact of superfusion-induced heterogeneities occurring in the depth of the tissue on impulse propagation in superficial layers. Simulations demonstrated that both the pattern of activation as well as the distribution of extracellular potentials close to the surface remain essentially unchanged. This was true also for the electrophysiological properties of cells in the surface layer, where most relevant depolarization parameters varied by less than 5.5?%. The main observed effect on the surface was related to action potential duration that shortened noticeably by 53?% as hypoxia deteriorated. Despite the known limitations of such experimental methods, we conclude that superfusion is adequate for studying impulse propagation and depolarization whereas repolarization studies should consider the influence of pathological processes taking place at the core of tissue sample.

Resumo Limpo

thinwal cardiac tissu sampl superfus oxygen solut wide use experiment studi howev due decreas oxygen suppli insuffici wash wast product inner layer prepar electrophysiolog function compromis although cascad event trigger cut perfus well known remain unclear degre electrophysiolog function viabl surfac layer affect patholog process occur adjac tissu use d numer bidomain model aim quantifi impact superfusioninduc heterogen occur depth tissu impuls propag superfici layer simul demonstr pattern activ well distribut extracellular potenti close surfac remain essenti unchang true also electrophysiolog properti cell surfac layer relev depolar paramet vari less main observ effect surfac relat action potenti durat shorten notic hypoxia deterior despit known limit experiment method conclud superfus adequ studi impuls propag depolar wherea repolar studi consid influenc patholog process take place core tissu sampl

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