Med Biol Eng Comput - Strategy for NSAID administration to aspirin-intolerant asthmatics in combination with PGE2 analogue: a theoretical approach.

Tópicos

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Resumo

Aspirin-induced asthma (AIA) is a severe inflammatory disease, which affects aspirin-intolerant patients after ingestion of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). In this article, a mathematical model describing arachidonic acid metabolism and its interaction with NSAIDs, is used to study the strategy for safe managing of NSAIDs to AIA patients. Three different AIA patient populations are taken into consideration. First, the values of aspirin and ibuprofen limiting doses that might induce symptoms of AIA are calculated and compared to experimentally observed threshold doses to enlighten which AIA patient population is susceptible to aspirin and ibuprofen. Second, the methodology of NSAID administration is studied on AIA populations susceptible to aspirin and ibuprofen by using 1,000 mg dose of aspirin and 200 or 400 mg dose of ibuprofen followed by PGE(2) analogue dosing. Our model results show that successive doses of PGE(2) analogue applied at appropriate time after aspirin or ibuprofen ingestion would enable administration of both NSAIDs to AIA patients. PGE(2) analogue doses and the corresponding times of their applications are calculated. The model is also used to estimate the duration of symptoms of AIA for different aspirin and ibuprofen doses.

Resumo Limpo

aspirininduc asthma aia sever inflammatori diseas affect aspirinintoler patient ingest aspirin nonsteroid antiinflammatori drug nsaid articl mathemat model describ arachidon acid metabol interact nsaid use studi strategi safe manag nsaid aia patient three differ aia patient popul taken consider first valu aspirin ibuprofen limit dose might induc symptom aia calcul compar experiment observ threshold dose enlighten aia patient popul suscept aspirin ibuprofen second methodolog nsaid administr studi aia popul suscept aspirin ibuprofen use mg dose aspirin mg dose ibuprofen follow pge analogu dose model result show success dose pge analogu appli appropri time aspirin ibuprofen ingest enabl administr nsaid aia patient pge analogu dose correspond time applic calcul model also use estim durat symptom aia differ aspirin ibuprofen dose

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