Med Biol Eng Comput - Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation.

Tópicos

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Resumo

The aim was to quantify the influence of heterogeneous isotropic and heterogeneous anisotropic tissue on the spatial distribution of the electric field during deep brain stimulation (DBS). Three finite element tissue models were created of one patient treated with DBS. Tissue conductivity was modelled as (I) homogeneous isotropic, (II) heterogeneous isotropic based on MRI, and (III) heterogeneous anisotropic based on diffusion tensor MRI. Modelled DBS electrodes were positioned in the subthalamic area, the pallidum, and the internal capsule in each tissue model. Electric fields generated during DBS were simulated for each model and target-combination and visualized with isolevels at 0.20 (inner), and 0.05 V mm(-1) (outer). Statistical and vector analysis was used for evaluation of the distribution of the electric field. Heterogeneous isotropic tissue altered the spatial distribution of the electric field by up to 4% at inner, and up to 10% at outer isolevel. Heterogeneous anisotropic tissue influenced the distribution of the electric field by up to 18 and 15% at each isolevel, respectively. The influence of heterogeneous and anisotropic tissue on the electric field may be clinically relevant in anatomic regions that are functionally subdivided and surrounded by multiple fibres of passage.

Resumo Limpo

aim quantifi influenc heterogen isotrop heterogen anisotrop tissu spatial distribut electr field deep brain stimul dbs three finit element tissu model creat one patient treat dbs tissu conduct model homogen isotrop ii heterogen isotrop base mri iii heterogen anisotrop base diffus tensor mri model dbs electrod posit subthalam area pallidum intern capsul tissu model electr field generat dbs simul model targetcombin visual isolevel inner v mm outer statist vector analysi use evalu distribut electr field heterogen isotrop tissu alter spatial distribut electr field inner outer isolevel heterogen anisotrop tissu influenc distribut electr field isolevel respect influenc heterogen anisotrop tissu electr field may clinic relev anatom region function subdivid surround multipl fibr passag

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