Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation.

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Resumo

The relationship between microarchitecture to the failure mechanism and mechanical properties can be assessed through experimental and computational methods. In this study, both methods were utilised using bovine cadavers. Twenty four samples of cancellous bone were extracted from fresh bovine and the samples were cleaned from excessive marrow. Uniaxial compression testing was performed with displacement control. After mechanical testing, each specimen was ashed in a furnace. Four of the samples were exemplarily scanned using micro-computed tomography (?CT) and three dimensional models of the cancellous bones were reconstructed for finite element simulation. The mechanical properties and the failure modes obtained from numerical simulations were then compared to the experiments. Correlations between microarchitectural parameters to the mechanical properties and failure modes were then made. The Young's modulus correlates well with the bone volume fraction with R? = 0.615 and P value 0.013. Three different types of failure modes of cancellous bone were observed: oblique fracture (21.7%), perpendicular global fracture (47.8%), and scattered localised fracture (30.4%). However, no correlations were found between the failure modes to the morphological parameters. The percentage of error between computer predictions and the actual experimental test was from 6 to 12%. These mechanical properties and information on failure modes can be used for the development of synthetic cancellous bone.

Resumo Limpo

relationship microarchitectur failur mechan mechan properti can assess experiment comput method studi method utilis use bovin cadav twenti four sampl cancel bone extract fresh bovin sampl clean excess marrow uniaxi compress test perform displac control mechan test specimen ash furnac four sampl exemplarili scan use microcomput tomographi ct three dimension model cancel bone reconstruct finit element simul mechan properti failur mode obtain numer simul compar experi correl microarchitectur paramet mechan properti failur mode made young modulus correl well bone volum fraction r p valu three differ type failur mode cancel bone observ obliqu fractur perpendicular global fractur scatter localis fractur howev correl found failur mode morpholog paramet percentag error comput predict actual experiment test mechan properti inform failur mode can use develop synthet cancel bone

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