Med Biol Eng Comput - Differential remodeling responses of cerebral and skeletal muscle arterioles in a novel organ culture system.

Tópicos

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Resumo

Evidence suggests that maladaptive changes in the cerebral microcirculation may contribute to ischemia in numerous diseases. We sought, therefore, to develop an ex vivo organ culture system to study early changes in cerebral arteriolar structure and function, and to compare associated findings to those for non-cerebral arterioles. Pilot studies revealed that rabbit cerebral arterioles maintained contractility longer when cultured in media containing rabbit-specific plasma rather than fetal bovine serum. Cerebral and skeletal muscle arterioles were cultured in a pressure myograph for 5 days; maximum dilatory and contractile responses were measured at 0, 1, 3, and 5 days. Passive properties were preserved in cerebral arterioles over the entire culture period, although skeletal muscle arterioles underwent constrictive remodeling. Cerebral arterioles also maintained a myogenic capability over the entire culture period, albeit at progressively larger diameters, whereas the skeletal muscle arterioles did so only over 3 days. Culture in rabbit serum, which contains numerous growth factors and clotting factors, did not induce or increase inward remodeling in cerebral or skeletal arterioles. These results suggest inherent, organ-specific differences in arteriolar remodeling, and that extensive results in the literature on non-cerebral arterioles should not be extrapolated to predict responses in the cerebral microcirculation.

Resumo Limpo

evid suggest maladapt chang cerebr microcircul may contribut ischemia numer diseas sought therefor develop ex vivo organ cultur system studi earli chang cerebr arteriolar structur function compar associ find noncerebr arteriol pilot studi reveal rabbit cerebr arteriol maintain contractil longer cultur media contain rabbitspecif plasma rather fetal bovin serum cerebr skelet muscl arteriol cultur pressur myograph day maximum dilatori contractil respons measur day passiv properti preserv cerebr arteriol entir cultur period although skelet muscl arteriol underw constrict remodel cerebr arteriol also maintain myogen capabl entir cultur period albeit progress larger diamet wherea skelet muscl arteriol day cultur rabbit serum contain numer growth factor clot factor induc increas inward remodel cerebr skelet arteriol result suggest inher organspecif differ arteriolar remodel extens result literatur noncerebr arteriol extrapol predict respons cerebr microcircul

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