Med Biol Eng Comput - Improved detection of fluorescently labeled microspheres and vessel architecture with an imaging cryomicrotome.

Tópicos

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Resumo

Due to spectral overlap, the number of fluorescent labels for imaging cryomicrotome detection was limited to 4. The aim of this study was to increase the separation of fluorescent labels. In the new imaging cryomicrotome, the sample is cut in slices of 40 microm. Six images are taken for each cutting plane. Correction for spectral overlap is based on linear combinations of fluorescent images. Locations of microspheres are determined by using the system point spread function. Five differently colored microspheres were injected in vivo distributed over two major coronaries, the left anterior descending and left circumflex artery. Under absence of collateral flow, microspheres outside of target perfusion territories were not found and the procedure did not generate false positive detection when spectral overlap was relevant. In silico-generated microspheres were used to test the effect of background image, transparency correction, and color separation. The percentage of microspheres undetected was 2.3 +/- 0.8% in the presence and 1.5 +/- 0.4% in the absence of background structures with a density of 900 microspheres per color per cm(3). The image analysis method presented here, allows for an increased number of experimental conditions that can be investigated in studies of regional myocardial perfusion.

Resumo Limpo

due spectral overlap number fluoresc label imag cryomicrotom detect limit aim studi increas separ fluoresc label new imag cryomicrotom sampl cut slice microm six imag taken cut plane correct spectral overlap base linear combin fluoresc imag locat microspher determin use system point spread function five differ color microspher inject vivo distribut two major coronari left anterior descend left circumflex arteri absenc collater flow microspher outsid target perfus territori found procedur generat fals posit detect spectral overlap relev silicogener microspher use test effect background imag transpar correct color separ percentag microspher undetect presenc absenc background structur densiti microspher per color per cm imag analysi method present allow increas number experiment condit can investig studi region myocardi perfus

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