Med Biol Eng Comput - Cell sheet integrity and nanomechanical breakdown during programmed cell death.

Tópicos

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Resumo

Apoptosis is a critical physiological pathway required for the normal functioning, homeostasis, and development of many organisms. This process is highly regulated at the biochemical level and has been intensively studied. Recent evidence has demonstrated that apoptosis is also a controlled nanomechanical process which relies on feedback between biochemical signaling and the nanomechanical properties of the microenvironment. Deregulation of the nanomechanical breakdown of apoptotic cells results in the poorly timed release of cells and cell debris that leads to the pathogenesis of several inflammatory diseases. In this study, we investigate the nanomechanical consequences of early apoptosis in human fibroblasts grown as single cells and as cell monolayers. These fibroblasts are found within the body and are involved in many processes including wound healing and repair in which apoptosis plays a major role. We find that although the cells undergo massive morphological remodeling and nanomechanical breakdown, the extra-cellular matrix (ECM) acts to maintain monolayer integrity. Via strong interactions between fibronectin and F-actin (fibronexus junctions), the ECM maintains and reinforces cell monolayers during breakdown. This study sheds new insights on our understanding of apoptosis and how biological systems utilize multiple inter- and intra-cytoarchitectures to regulate nanomechanical breakdown.

Resumo Limpo

apoptosi critic physiolog pathway requir normal function homeostasi develop mani organ process high regul biochem level intens studi recent evid demonstr apoptosi also control nanomechan process reli feedback biochem signal nanomechan properti microenviron deregul nanomechan breakdown apoptot cell result poor time releas cell cell debri lead pathogenesi sever inflammatori diseas studi investig nanomechan consequ earli apoptosi human fibroblast grown singl cell cell monolay fibroblast found within bodi involv mani process includ wound heal repair apoptosi play major role find although cell undergo massiv morpholog remodel nanomechan breakdown extracellular matrix ecm act maintain monolay integr via strong interact fibronectin factin fibronexus junction ecm maintain reinforc cell monolay breakdown studi shed new insight understand apoptosi biolog system util multipl inter intracytoarchitectur regul nanomechan breakdown

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