Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological?

Tópicos

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Resumo

The objective here was to experimentally characterize the temporal evolution of the structural and mechanical properties of large volume immature regenerated tissues. We studied these evolving tissues from their genesis in controlled mechanical conditions. We developed an animal model based on the periosteal properties leading to unloaded regenerated skeletal tissue. To characterize the temporal evolution of mechanical properties, we carried out indentation tests coupled with macroscopic examinations and histological studies. This combined methodology yielded a range of information on osteogenesis at different scales: macroscopic by simple observation, mesoscopic by indentation test and microscopic by histological study. Results allowed us to identify different periods, providing a link between biological changes and material property evolution in bone tissue regeneration. The regenerated tissue evolves from a viscous, homogeneous, soft material to a heterogeneous stiffer material endowed with a lower viscosity. From a biological point of view, cell organization progresses from a proliferated cell clot to a mature structure closer to that of the bone. During the first 7 days, mechanical and biological results revealed the same evolution: first, the regenerated tissue grew, then, differentiated into an osteochondral tissue and finally calcification began. While our biological results confirm those of other studies, our mechanical results provide the first experimental mechanical characterization by reduced Young's modulus of such tissue.

Resumo Limpo

object experiment character tempor evolut structur mechan properti larg volum immatur regener tissu studi evolv tissu genesi control mechan condit develop anim model base periost properti lead unload regener skelet tissu character tempor evolut mechan properti carri indent test coupl macroscop examin histolog studi combin methodolog yield rang inform osteogenesi differ scale macroscop simpl observ mesoscop indent test microscop histolog studi result allow us identifi differ period provid link biolog chang materi properti evolut bone tissu regener regener tissu evolv viscous homogen soft materi heterogen stiffer materi endow lower viscos biolog point view cell organ progress prolifer cell clot matur structur closer bone first day mechan biolog result reveal evolut first regener tissu grew differenti osteochondr tissu final calcif began biolog result confirm studi mechan result provid first experiment mechan character reduc young modulus tissu

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