Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process.

Tópicos

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Resumo

In magnetic nanoparticle hyperthermia for cancer treatment, controlling the nanoparticle distribution delivered in tumors is vital for achieving an optimum distribution of temperature elevations that enables a maximum damage of the tumorous cells while minimizing the heating in the surrounding healthy tissues. A multi-scale model is developed in this study to investigate the spatial distribution of nanoparticles in tissues after nanofluid injection into the extracellular space of tissues. The theoretical study consists of a particle trajectory tracking model that considers particle-surface interactions and a macroscale model for the transport of nanoparticles in the carrier solution in a porous structure. Simulations are performed to examine the effects of a variety of injection parameters and particle properties on the particle distribution in tissues. The results show that particle deposition on the cellular structure is the dominant mechanism that leads to a non-uniform particle distribution. The particle penetration depth is sensitive to the injection rate and surface properties of the particles, but relatively insensitive to the injected volume and concentration of the nanofluid.

Resumo Limpo

magnet nanoparticl hyperthermia cancer treatment control nanoparticl distribut deliv tumor vital achiev optimum distribut temperatur elev enabl maximum damag tumor cell minim heat surround healthi tissu multiscal model develop studi investig spatial distribut nanoparticl tissu nanofluid inject extracellular space tissu theoret studi consist particl trajectori track model consid particlesurfac interact macroscal model transport nanoparticl carrier solut porous structur simul perform examin effect varieti inject paramet particl properti particl distribut tissu result show particl deposit cellular structur domin mechan lead nonuniform particl distribut particl penetr depth sensit inject rate surfac properti particl relat insensit inject volum concentr nanofluid

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