Med Biol Eng Comput - Microfabricated substrates as a tool to study cell mechanotransduction.

Tópicos

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Resumo

Mechanical cell-substrate interactions affect many cellular functions such as spreading, migration, and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the mechanical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In particular, this includes the transmission of forces as well as rigidity and topography sensing mechanisms. Here, we review techniques and tools based on nano- and micro-fabrication that have been developed to analyze the influence of the mechanical properties of the substrate on cell functions. We also discuss how microfabrication methods have improved our knowledge on cell adhesion and migration and how they could solve remaining problems in the field of mechanobiology.

Resumo Limpo

mechan cellsubstr interact affect mani cellular function spread migrat even differenti interact can studi incorpor micro nanotechnologyrel tool design substrat base technolog offer new possibl probe cellular respons chang physic environ investig mechan interact cell surround matrix can carri welldefin near physiolog condit particular includ transmiss forc well rigid topographi sens mechan review techniqu tool base nano microfabr develop analyz influenc mechan properti substrat cell function also discuss microfabr method improv knowledg cell adhes migrat solv remain problem field mechanobiolog

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