Med Biol Eng Comput - A method to determine in vivo, specific airway compliance, in humans.

Tópicos

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Resumo

In order to understand the pathophysiology of diseases such as asthma and chronic obstructive pulmonary disease, it is essential to measure the mechanical properties of the airways. Currently, there are no methods to measure and quantify in vivo airway compliance in humans. In order to develop a method, we generated a curve-fitting algorithm that combines airway diameter measurements by high resolution computed tomography with pressure-volume curves obtained by the esophageal balloon technique. Our method allows the description of diameter-pressure curves for airways of varying size, presented as a 3D surface, from which specific airway compliance can be determined at any transpulmonary pressure. Applying this method to data from two healthy subjects, we found that small airways are more compliant than large airways and specific airway compliance was greatest at low transpulmonary pressures. In conclusion, our 3D surface is a useful tool to measure and quantify in vivo specific airway compliance in humans.

Resumo Limpo

order understand pathophysiolog diseas asthma chronic obstruct pulmonari diseas essenti measur mechan properti airway current method measur quantifi vivo airway complianc human order develop method generat curvefit algorithm combin airway diamet measur high resolut comput tomographi pressurevolum curv obtain esophag balloon techniqu method allow descript diameterpressur curv airway vari size present d surfac specif airway complianc can determin transpulmonari pressur appli method data two healthi subject found small airway compliant larg airway specif airway complianc greatest low transpulmonari pressur conclus d surfac use tool measur quantifi vivo specif airway complianc human

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