Med Decis Making - Minimal modeling approaches to value of information analysis for health research.

Tópicos

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Resumo

Value of information (VOI) techniques can provide estimates of the expected benefits from clinical research studies that can inform decisions about the design and priority of those studies. Most VOI studies use decision-analytic models to characterize the uncertainty of the effects of interventions on health outcomes, but the complexity of constructing such models can pose barriers to some practical applications of VOI. However, because some clinical studies can directly characterize uncertainty in health outcomes, it may sometimes be possible to perform VOI analysis with only minimal modeling. This article 1) develops a framework to define and classify minimal modeling approaches to VOI, 2) reviews existing VOI studies that apply minimal modeling approaches, and 3) illustrates and discusses the application of the minimal modeling to 2 new clinical applications to which the approach appears well suited because clinical trials with comprehensive outcomes provide preliminary estimates of the uncertainty in outcomes. The authors conclude that minimal modeling approaches to VOI can be readily applied in some instances to estimate the expected benefits of clinical research.

Resumo Limpo

valu inform voi techniqu can provid estim expect benefit clinic research studi can inform decis design prioriti studi voi studi use decisionanalyt model character uncertainti effect intervent health outcom complex construct model can pose barrier practic applic voi howev clinic studi can direct character uncertainti health outcom may sometim possibl perform voi analysi minim model articl develop framework defin classifi minim model approach voi review exist voi studi appli minim model approach illustr discuss applic minim model new clinic applic approach appear well suit clinic trial comprehens outcom provid preliminari estim uncertainti outcom author conclud minim model approach voi can readili appli instanc estim expect benefit clinic research

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