Med Decis Making - Personalized medicine and genomics: challenges and opportunities in assessing effectiveness, cost-effectiveness, and future research priorities.

Tópicos

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Resumo

Personalized medicine is health care that tailors interventions to individual variation in risk and treatment response. Although medicine has long strived to achieve this goal, advances in genomics promise to facilitate this process. Relevant to present-day practice is the use of genomic information to classify individuals according to disease susceptibility or expected responsiveness to a pharmacologic treatment and to provide targeted interventions. A symposium at the annual meeting of the Society for Medical Decision Making on 23 October 2007 highlighted the challenges and opportunities posed in translating advances in molecular medicine into clinical practice. A panel of US experts in medical practice, regulatory policy, technology assessment, and the financing and organization of medical innovation was asked to discuss the current state of practice and research on personalized medicine as it relates to their own field. This article reports on the issues raised, discusses potential approaches to meet these challenges, and proposes directions for future work. The case of genetic testing to inform dosing with warfarin, an anticoagulant, is used to illustrate differing perspectives on evidence and decision making for personalized medicine.

Resumo Limpo

person medicin health care tailor intervent individu variat risk treatment respons although medicin long strive achiev goal advanc genom promis facilit process relev presentday practic use genom inform classifi individu accord diseas suscept expect respons pharmacolog treatment provid target intervent symposium annual meet societi medic decis make octob highlight challeng opportun pose translat advanc molecular medicin clinic practic panel us expert medic practic regulatori polici technolog assess financ organ medic innov ask discuss current state practic research person medicin relat field articl report issu rais discuss potenti approach meet challeng propos direct futur work case genet test inform dose warfarin anticoagul use illustr differ perspect evid decis make person medicin

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