Methods Inf Med - A simplification and implementation of random-effects meta-analyses based on the exact distribution of Cochran's Q.


{ method(1219) similar(1157) match(930) }
{ estim(2440) model(1874) function(577) }
{ algorithm(1844) comput(1787) effici(935) }
{ assess(1506) score(1403) qualiti(1306) }
{ case(1353) use(1143) diagnosi(1136) }
{ take(945) account(800) differ(722) }
{ data(2317) use(1299) case(1017) }
{ data(3008) multipl(1320) sourc(1022) }
{ model(3404) distribut(989) bayesian(671) }
{ error(1145) method(1030) estim(1020) }
{ data(1714) softwar(1251) tool(1186) }
{ patient(2315) diseas(1263) diabet(1191) }
{ spatial(1525) area(1432) region(1030) }
{ risk(3053) factor(974) diseas(938) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ sampl(1606) size(1419) use(1276) }
{ motion(1329) object(1292) video(1091) }
{ general(901) number(790) one(736) }
{ perform(1367) use(1326) method(1137) }
{ age(1611) year(1155) adult(843) }
{ first(2504) two(1366) second(1323) }
{ system(1976) rule(880) can(841) }
{ imag(2830) propos(1344) filter(1198) }
{ problem(2511) optim(1539) algorithm(950) }
{ learn(2355) train(1041) set(1003) }
{ model(3480) simul(1196) paramet(876) }
{ can(981) present(881) function(850) }
{ method(1969) cluster(1462) data(1082) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ featur(3375) classif(2383) classifi(1994) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ studi(2440) review(1878) systemat(933) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ gene(2352) biolog(1181) express(1162) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }


CKGROUND: The random-effects (RE) model is the standard choice for meta-analysis in the presence of heterogeneity, and the standard RE method is the DerSimonian and Laird (DSL) approach, where the degree of heterogeneity is estimated using a moment-estimator. The DSL approach does not take into account the variability of the estimated heterogeneity variance in the estimation of Cochran's Q. Biggerstaff and Jackson derived the exact cumulative distribution function (CDF) of Q to account for the variability of t^?.OBJECTIVES: The first objective is to show that the explicit numerical computation of the density function of Cochran's Q is not required. The second objective is to develop an R package with the possibility to easily calculate the classical RE method and the new exact RE method.METHODS: The novel approach was validated in extensive simulation studies. The different approaches used in the simulation studies, including the exact weights RE meta-analysis, the I? and t? estimates together with their confidence intervals were implemented in the R package metaxa.RESULTS: The comparison with the classical DSL method showed that the exact weights RE meta-analysis kept the nominal type I error level better and that it had greater power in case of many small studies and a single large study. The Hedges RE approach had inflated type I error levels. Another advantage of the exact weights RE meta-analysis is that an exact confidence interval for t? is readily available. The exact weights RE approach had greater power in case of few studies, while the restricted maximum likelihood (REML) approach was superior in case of a large number of studies. Differences between the exact weights RE meta-analysis and the DSL approach were observed in the re-analysis of real data sets. Application of the exact weights RE meta-analysis, REML, and the DSL approach to real data sets showed that conclusions between these methods differed.CONCLUSIONS: The simplification does not require the calculation of the density of Cochran's Q, but only the calculation of the cumulative distribution function, while the previous approach required the computation of both the density and the cumulative distribution function. It thus reduces computation time, improves numerical stability, and reduces the approximation error in meta-analysis. The different approaches, including the exact weights RE meta-analysis, the I? and t? estimates together with their confidence intervals are available in the R package metaxa, which can be used in applications.

Resumo Limpo

ckground randomeffect re model standard choic metaanalysi presenc heterogen standard re method dersimonian laird dsl approach degre heterogen estim use momentestim dsl approach take account variabl estim heterogen varianc estim cochran q biggerstaff jackson deriv exact cumul distribut function cdf q account variabl tobject first object show explicit numer comput densiti function cochran q requir second object develop r packag possibl easili calcul classic re method new exact re methodmethod novel approach valid extens simul studi differ approach use simul studi includ exact weight re metaanalysi t estim togeth confid interv implement r packag metaxaresult comparison classic dsl method show exact weight re metaanalysi kept nomin type error level better greater power case mani small studi singl larg studi hedg re approach inflat type error level anoth advantag exact weight re metaanalysi exact confid interv t readili avail exact weight re approach greater power case studi restrict maximum likelihood reml approach superior case larg number studi differ exact weight re metaanalysi dsl approach observ reanalysi real data set applic exact weight re metaanalysi reml dsl approach real data set show conclus method differedconclus simplif requir calcul densiti cochran q calcul cumul distribut function previous approach requir comput densiti cumul distribut function thus reduc comput time improv numer stabil reduc approxim error metaanalysi differ approach includ exact weight re metaanalysi t estim togeth confid interv avail r packag metaxa can use applic

Resumos Similares

Neural Comput - Nonparametric estimation of K?llback-Leibler divergence. ( 0,763006290224562 )
Lifetime Data Anal - Comparison of estimators in nested case-control studies with multiple outcomes. ( 0,736795894922629 )
Med Decis Making - Methods for estimating subgroup effects in cost-effectiveness analyses that use observational data. ( 0,731944058490601 )
Methods Inf Med - The utility of imputed matched sets. Analyzing probabilistically linked databases in a low information setting. ( 0,728671628763961 )
Comput Math Methods Med - An empirical likelihood method for semiparametric linear regression with right censored data. ( 0,71831450893359 )
Res Synth Methods - Semiparametric hazard function estimation in meta-analysis for time to event data. ( 0,692531365405802 )
Neural Comput - Least squares estimation without priors or supervision. ( 0,688490872205353 )
Res Synth Methods - Confidence intervals for the between-study variance in random effects meta-analysis using generalised Cochran heterogeneity statistics. ( 0,687166675277679 )
Lifetime Data Anal - Events per variable for risk differences and relative risks using pseudo-observations. ( 0,658506505838573 )
J Chem Inf Model - Build-up algorithm for atomic correspondence between chemical structures. ( 0,658063688012217 )
Artif Intell Med - Intelligent quotient estimation of mental retarded people from different psychometric instruments using artificial neural networks. ( 0,652470357535218 )
Lifetime Data Anal - Imputation for semiparametric transformation models with biased-sampling data. ( 0,643776856969982 )
IEEE Trans Image Process - Correlation-coefficient-based fast template matching through partial elimination. ( 0,642438957193285 )
Lifetime Data Anal - Marginal semiparametric multivariate accelerated failure time model with generalized estimating equations. ( 0,628077034959067 )
Med Decis Making - Regression estimators for generic health-related quality of life and quality-adjusted life years. ( 0,622307161091668 )
J. Comput. Biol. - Improved harmonic mean estimator for phylogenetic model evidence. ( 0,620214417269822 )
Lifetime Data Anal - A Bayesian proportional hazards model for general interval-censored data. ( 0,620085745632026 )
IEEE Trans Image Process - Maximum likelihood orientation estimation of 1-D patterns in Laguerre-Gauss subspaces. ( 0,618948642113076 )
Comput Methods Programs Biomed - Model based period analysis of absolute and relative survival with R: data preparation, model fitting and derivation of survival estimates. ( 0,616245951973385 )
Lifetime Data Anal - A generalization of Turnbull's estimator for nonparametric estimation of the conditional survival function with interval-censored data. ( 0,615131249996268 )
Neural Comput - Reliability of information-based integration of EEG and fMRI data: a simulation study. ( 0,614394541181652 )
Lifetime Data Anal - Predictive comparison of joint longitudinal-survival modeling: a case study illustrating competing approaches. ( 0,610041376367708 )
J. Comput. Biol. - Shape-based feature matching improves protein identification via LC-MS and tandem MS. ( 0,607431713442464 )
Med Decis Making - Generalized additive models for the analysis of EQ-5D utility data. ( 0,606944059041686 )
IEEE Trans Neural Netw Learn Syst - A Unified Framework for Data Visualization and Coclustering. ( 0,605596795266539 )
IEEE Trans Image Process - Nonlinear transform for robust dense block-based motion estimation. ( 0,605179760284694 )
Lifetime Data Anal - Regression analysis for cumulative incidence probability under competing risks and left-truncated sampling. ( 0,603230008697865 )
Neural Comput - An estimation of generalized bradley-terry models based on the em algorithm. ( 0,602872813174761 )
Neural Comput - Firing variability is higher than deduced from the empirical coefficient of variation. ( 0,602818816829039 )
Lifetime Data Anal - A pool-adjacent-violators type algorithm for non-parametric estimation of current status data with dependent censoring. ( 0,601000658908866 )
Lifetime Data Anal - Computationally simple estimation and improved efficiency for special cases of double truncation. ( 0,600681870718562 )
Res Synth Methods - Meta-analysis of time-to-event data: a comparison of two-stage methods. ( 0,60005473852536 )
Lifetime Data Anal - Simultaneous marginal survival estimators when doubly censored data is present. ( 0,599167586417419 )
Lifetime Data Anal - Semiparametric methods for center effect measures based on the ratio of survival functions. ( 0,596028060902671 )
IEEE Trans Image Process - Flexible Image Similarity Computation Using Hyper-Spatial Matching. ( 0,595757405889059 )
IEEE Trans Image Process - One-dimensional mapping for estimating projective transformations. ( 0,595615470770954 )
Lifetime Data Anal - Nonparametric estimation with recurrent competing risks data. ( 0,593207276849981 )
Lifetime Data Anal - Competing risks with missing covariates: effect of haplotypematch on hematopoietic cell transplant patients. ( 0,590597125569986 )
Lifetime Data Anal - Pseudo-observations for competing risks with covariate dependent censoring. ( 0,589493444601913 )
Lifetime Data Anal - Regression analysis based on conditional likelihood approach under semi-competing risks data. ( 0,588455814529341 )
Lifetime Data Anal - A two-stage estimation in the Clayton-Oakes model with marginal linear transformation models for multivariate failure time data. ( 0,588014486374415 )
Res Synth Methods - Combining study outcome measures using dominance adjusted weights. ( 0,58382102164134 )
IEEE Trans Image Process - Nonlinearity detection in hyperspectral images using a polynomial post-nonlinear mixing model. ( 0,579645345255353 )
Comput Methods Programs Biomed - Flexible multivariate marginal models for analyzing multivariate longitudinal data, with applications in R. ( 0,57872161209487 )
Lifetime Data Anal - Estimating treatment effects on the marginal recurrent event mean in the presence of a terminating event. ( 0,575955575357706 )
Telemed J E Health - Measuring the effect of telecare on medical expenditures without bias using the propensity score matching method. ( 0,575536210839765 )
Lifetime Data Anal - On estimation of linear transformation models with nested case-control sampling. ( 0,575456317395776 )
Methods Inf Med - Assessing frequency domain causality in cardiovascular time series with instantaneous interactions. ( 0,575227856172343 )
Lifetime Data Anal - A parametric model fitting time to first event for overdispersed data: application to time to relapse in multiple sclerosis. ( 0,575205540381763 )
Lifetime Data Anal - Local linear estimation of concordance probability with application to covariate effects models on association for bivariate failure-time data. ( 0,574653638429222 )
Med Decis Making - Calculating Utility Decrements Associated With an Adverse Event: Marginal Tobit and CLAD Coefficients Should Be Used With Caution. ( 0,572524037497465 )
Lifetime Data Anal - Estimation in a competing risks proportional hazards model under length-biased sampling with censoring. ( 0,572411974836715 )
Lifetime Data Anal - Estimation of treatment effects based on possibly misspecified Cox regression. ( 0,570970189864331 )
Comput Math Methods Med - Application of seemingly unrelated regression in medical data with intermittently observed time-dependent covariates. ( 0,570085075234331 )
Med Decis Making - Underestimation of uncertainties in health utilities derived from mapping algorithms involving health-related quality-of-life measures: statistical explanations and potential remedies. ( 0,569963754347092 )
Med Decis Making - Adjusting survival time estimates to account for treatment switching in randomized controlled trials--an economic evaluation context: methods, limitations, and recommendations. ( 0,568081534977562 )
Lifetime Data Anal - Quantifying the average of the time-varying hazard ratio via a class of transformations. ( 0,567777471294663 )
Lifetime Data Anal - Nonparametric estimation of the cumulative intensities in an interval censored competing risks model. ( 0,567634538114304 )
J Chem Inf Model - Estimation of environment-related properties of chemicals for design of sustainable processes: development of group-contribution+ (GC+) property models and uncertainty analysis. ( 0,567447010489119 )
IEEE Trans Image Process - Interval-valued fuzzy sets applied to stereo matching of color images. ( 0,567198674197364 )
Lifetime Data Anal - Semiparametric additive marginal regression models for multiple type recurrent events. ( 0,565955080677029 )
Lifetime Data Anal - Profile local linear estimation of generalized semiparametric regression model for longitudinal data. ( 0,564540327622892 )
BMC Med Inform Decis Mak - Concordance between decision analysis and matching systematic review of randomized controlled trials in assessment of treatment comparisons: a systematic review. ( 0,564338663525192 )
Lifetime Data Anal - Nonparametric quasi-likelihood for right censored data. ( 0,563913024374224 )
J. Comput. Biol. - Separating significant matches from spurious matches in DNA sequences. ( 0,563904005557979 )
Lifetime Data Anal - Matched survival data in a co-twin control design. ( 0,5626707991918 )
Comput Math Methods Med - Gray's time-varying coefficients model for posttransplant survival of pediatric liver transplant recipients with a diagnosis of cancer. ( 0,55964985675751 )
Comput Methods Programs Biomed - Bayesian Decision Trees for predicting survival of patients: a study on the US National Trauma Data Bank. ( 0,558298264693915 )
Lifetime Data Anal - A functional inference for multivariate current status data with mismeasured covariate. ( 0,557137370362975 )
Comput Methods Programs Biomed - Monte Carlo simulation of parameter confidence intervals for non-linear regression analysis of biological data using Microsoft Excel. ( 0,556967268042708 )
Med Decis Making - Eliciting benefit-risk preferences and probability-weighted utility using choice-format conjoint analysis. ( 0,55601188546744 )
Lifetime Data Anal - Evaluating hospital readmission rates in dialysis facilities; adjusting for hospital effects. ( 0,553573625920408 )
Lifetime Data Anal - Estimation of cumulative incidence functions when the lifetime distributions are uniformly stochastically ordered. ( 0,552839787518228 )
Lifetime Data Anal - Estimation of odds of concordance based on the Aalen additive model. ( 0,552808523495947 )
Res Synth Methods - Comparison of statistical inferences from the DerSimonian-Laird and alternative random-effects model meta-analyses - an empirical assessment of 920 Cochrane primary outcome meta-analyses. ( 0,551044410409248 )
Res Synth Methods - Robust variance estimation in meta-regression with dependent effect size estimates. ( 0,550994919330402 )
Comput Methods Programs Biomed - A simulation procedure based on copulas to generate clustered multi-state survival data. ( 0,549113895010521 )
Lifetime Data Anal - A hierarchical frailty model applied to two-generation melanoma data. ( 0,547624769024867 )
Lifetime Data Anal - Robust inference in discrete hazard models for randomized clinical trials. ( 0,547023048721525 )
IEEE Trans Pattern Anal Mach Intell - Bayesian Nonparametric Models for Multiway Data Analysis. ( 0,545737009513711 )
Lifetime Data Anal - Additive-multiplicative rates model for recurrent events. ( 0,54508911023677 )
Lifetime Data Anal - Linear regression analysis of survival data with missing censoring indicators. ( 0,544961578878057 )
Comput Methods Programs Biomed - mmm: an R package for analyzing multivariate longitudinal data with multivariate marginal models. ( 0,54447287795051 )
Lifetime Data Anal - Cox regression for mixed case interval-censored data with covariate errors. ( 0,543787200086582 )
Int J Med Inform - Content analysis of physical examination templates in electronic health records using SNOMED CT. ( 0,543766892770699 )
Comput Methods Programs Biomed - Fitting semiparametric regressions for panel count survival data with an R package spef. ( 0,543719532127889 )
Lifetime Data Anal - Exact goodness-of-fit tests for shape-scale families and type II censoring. ( 0,543309348912099 )
IEEE Trans Image Process - A tuned mesh-generation strategy for image representation based on data-dependent triangulation. ( 0,5432729445987 )
Comput. Biol. Med. - A bilateral analysis scheme for false positive reduction in mammogram mass detection. ( 0,542396181328052 )
IEEE Trans Image Process - On the method of logarithmic cumulants for parametric probability density function estimation. ( 0,540354906333062 )
Lifetime Data Anal - Likelihood ratio procedures and tests of fit in parametric and semiparametric copula models with censored data. ( 0,538484063060806 )
Lifetime Data Anal - Proportional hazards regression in the presence of missing study eligibility information. ( 0,537878165307724 )
IEEE Trans Image Process - Missing texture reconstruction method based on error reduction algorithm using Fourier transform magnitude estimation scheme. ( 0,535893375029835 )
Lifetime Data Anal - Robust methods to improve efficiency and reduce bias in estimating survival curves in randomized clinical trials. ( 0,53425411938065 )
Comput. Biol. Med. - Modeling and prediction of peptide drift times in ion mobility spectrometry using sequence-based and structure-based approaches. ( 0,532823694390632 )
Res Synth Methods - Robust variance estimation with dependent effect sizes: practical considerations including a software tutorial in Stata and spss. ( 0,532702761759831 )
Lifetime Data Anal - The beta modified Weibull distribution. ( 0,532541346406957 )
Lifetime Data Anal - Non-crossing weighted kernel quantile regression with right censored data. ( 0,532268264581316 )
J. Comput. Biol. - An optimization-based sampling scheme for phylogenetic trees. ( 0,531824416905977 )
Lifetime Data Anal - Marginal hazard regression for correlated failure time data with auxiliary covariates. ( 0,531504962882868 )