Methods Inf Med - Influence of selection bias on the test decision. A simulation study.

Tópicos

{ sampl(1606) size(1419) use(1276) }
{ take(945) account(800) differ(722) }
{ estim(2440) model(1874) function(577) }
{ risk(3053) factor(974) diseas(938) }
{ model(2341) predict(2261) use(1141) }
{ data(3963) clinic(1234) research(1004) }
{ time(1939) patient(1703) rate(768) }
{ studi(2440) review(1878) systemat(933) }
{ error(1145) method(1030) estim(1020) }
{ measur(2081) correl(1212) valu(896) }
{ general(901) number(790) one(736) }
{ group(2977) signific(1463) compar(1072) }
{ clinic(1479) use(1117) guidelin(835) }
{ perform(1367) use(1326) method(1137) }
{ research(1218) medic(880) student(794) }
{ cost(1906) reduc(1198) effect(832) }
{ activ(1138) subject(705) human(624) }
{ process(1125) use(805) approach(778) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ data(2317) use(1299) case(1017) }
{ first(2504) two(1366) second(1323) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ featur(3375) classif(2383) classifi(1994) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ model(2220) cell(1177) simul(1124) }
{ search(2224) databas(1162) retriev(909) }
{ case(1353) use(1143) diagnosi(1136) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ state(1844) use(1261) util(961) }
{ age(1611) year(1155) adult(843) }
{ intervent(3218) particip(2042) group(1664) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ model(3404) distribut(989) bayesian(671) }
{ data(1737) use(1416) pattern(1282) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ motion(1329) object(1292) video(1091) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ patient(1821) servic(1111) care(1106) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

CKGROUND: Selection bias arises in clinical trials by reason of selective assignment of patients to treatment groups. Even in randomized clinical trials with allocation concealment this phenomenon can occur if future assignments can be predicted due to knowledge of former allocations.OBJECTIVES: Considering unmasked randomized clinical trials with allocation concealment the impact of selection bias on type I error rate under permuted block randomization is investigated. We aimed to extend the existing research into this topic by including practical assumptions concerning misclassification of patient characteristics to get an estimate of type I error close to clinical routine. To establish an upper bound for the type I error rate different biasing strategies of the investigator are compared first. In addition, the aspect of patient availability is considered.METHODS: To evaluate the influence of selection bias on type I error rate under several practical situations, different block sizes, selection effects, biasing strategies and success rates of patient classification were simulated using SAS.RESULTS: Type I error rate exceeds 5 percent significance level; it reaches values up to 21 percent. More cautious biasing strategies and misclassification of patient characteristics may diminish but cannot eliminate selection bias. The number of screened patients is about three times larger than the needed number for the trial.CONCLUSIONS: Even in unmasked randomized clinical trials using permuted block randomization with allocation concealment the influence of selection bias must not be disregarded evaluating the test decision. It should be incorporated when designing and reporting a clinical trial.

Resumo Limpo

ckground select bias aris clinic trial reason select assign patient treatment group even random clinic trial alloc conceal phenomenon can occur futur assign can predict due knowledg former allocationsobject consid unmask random clinic trial alloc conceal impact select bias type error rate permut block random investig aim extend exist research topic includ practic assumpt concern misclassif patient characterist get estim type error close clinic routin establish upper bound type error rate differ bias strategi investig compar first addit aspect patient avail consideredmethod evalu influenc select bias type error rate sever practic situat differ block size select effect bias strategi success rate patient classif simul use sasresult type error rate exceed percent signific level reach valu percent cautious bias strategi misclassif patient characterist may diminish elimin select bias number screen patient three time larger need number trialconclus even unmask random clinic trial use permut block random alloc conceal influenc select bias must disregard evalu test decis incorpor design report clinic trial

Resumos Similares

Comput Methods Programs Biomed - A bootstrap approach for lower injury levels of the risk curves. ( 0,678699780028913 )
Med Decis Making - Common scale valuations across different preference-based measures: estimation using rank data. ( 0,655489637485761 )
Lifetime Data Anal - Evaluating incremental values from new predictors with net reclassification improvement in survival analysis. ( 0,610722900461134 )
Methods Inf Med - Chronological bias in randomized clinical trials arising from different types of unobserved time trends. ( 0,609987491777483 )
Lifetime Data Anal - A competing risks model for correlated data based on the subdistribution hazard. ( 0,609324452287998 )
Methods Inf Med - Blinded sample size reestimation with negative binomial counts in superiority and non-inferiority trials. ( 0,60534857927697 )
Lifetime Data Anal - Events per variable for risk differences and relative risks using pseudo-observations. ( 0,591068725971763 )
Med Decis Making - Test result-based sampling: an efficient design for estimating the accuracy of patient safety indicators. ( 0,590546354472193 )
J Biomed Inform - Sample size estimation in diagnostic test studies of biomedical informatics. ( 0,573869091881811 )
Lifetime Data Anal - Estimation in a competing risks proportional hazards model under length-biased sampling with censoring. ( 0,562372844775055 )
Med Decis Making - Survival analysis for economic evaluations alongside clinical trials--extrapolation with patient-level data: inconsistencies, limitations, and a practical guide. ( 0,559375414692128 )
Lifetime Data Anal - Adopting nested case-control quota sampling designs for the evaluation of risk markers. ( 0,558735979713972 )
Lifetime Data Anal - Generalized random sign and alert delay models for imperfect maintenance. ( 0,553504269784142 )
IEEE Trans Pattern Anal Mach Intell - Accuracy of Pseudo-Inverse Covariance Learning-A Random Matrix Theory Analysis. ( 0,551756538010068 )
Lifetime Data Anal - Robust methods to improve efficiency and reduce bias in estimating survival curves in randomized clinical trials. ( 0,55155483361269 )
Res Synth Methods - Meta-regression approximations to reduce publication selection bias. ( 0,551176110217332 )
Med Decis Making - Lehmann family of ROC curves. ( 0,548925282749769 )
Methods Inf Med - Evaluation of imbalance in stratified blocked randomization: some remarks on the range of validity of the model by Hallstrom and Davis. ( 0,548755434182758 )
Lifetime Data Anal - Semiparametric inference on the absolute risk reduction and the restricted mean survival difference. ( 0,540892402544123 )
Methods Inf Med - Sample size reassessment in non-inferiority trials. Internal pilot study designs with ANCOVA. ( 0,540574666036354 )
Med Biol Eng Comput - Non-invasive diagnosis of risk in dengue patients using bioelectrical impedance analysis and artificial neural network. ( 0,538691789251013 )
J Chem Inf Model - Determining the degree of randomness of descriptors in linear regression equations with respect to the data size. ( 0,537956767876926 )
Res Synth Methods - Trial sequential methods for meta-analysis. ( 0,536574992668925 )
Lifetime Data Anal - Competing risks with missing covariates: effect of haplotypematch on hematopoietic cell transplant patients. ( 0,536429914675384 )
J Clin Monit Comput - Complex signals bioinformatics: evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis. ( 0,534246212347586 )
Res Synth Methods - Using meta-analysis to inform the design of subsequent studies of diagnostic test accuracy. ( 0,531231580531736 )
Med Decis Making - The hazards of extrapolating survival curves. ( 0,525090638248371 )
J Am Med Inform Assoc - A patient-driven adaptive prediction technique to improve personalized risk estimation for clinical decision support. ( 0,524144546166667 )
Spat Spatiotemporal Epidemiol - Estimation of district-level under-5 mortality in Zambia using birth history data, 1980-2010. ( 0,522825483582574 )
Comput Biol Chem - Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses. ( 0,522133793649706 )
J Med Syst - The effect of socio-cultural characteristics on the effectiveness of teamwork: a study in the G?lhane Military Medical Faculty Training Hospital. ( 0,521659540949571 )
Lifetime Data Anal - Estimating heritability for cause specific mortality based on twin studies. ( 0,520963849697583 )
Lifetime Data Anal - Comparison of stopped Cox regression with direct methods such as pseudo-values and binomial regression. ( 0,520086421035949 )
Int J Health Geogr - Modelling zoonotic diseases in humans: comparison of methods for hantavirus in Sweden. ( 0,519240811780194 )
Int J Health Geogr - Modeling larval malaria vector habitat locations using landscape features and cumulative precipitation measures. ( 0,517279152101243 )
Comput Methods Programs Biomed - Influenza vaccination and reduction in risk of ischemic heart disease among chronic obstructive pulmonary elderly. ( 0,513057234882476 )
BMC Med Inform Decis Mak - Using latent class analysis to model prescription medications in the measurement of falling among a community elderly population. ( 0,512157371296441 )
Med Decis Making - US valuation of the SF-6D. ( 0,510751619760338 )
Lifetime Data Anal - Semicompeting risks in aging research: methods, issues and needs. ( 0,510683916631099 )
Med Decis Making - Use of a catalytic model to estimate hepatitis A incidence in a low-endemicity country: implications for modeling immunization policies. ( 0,507958315453869 )
Comput Methods Programs Biomed - A warning concerning the estimation of multinomial logistic models with correlated responses in SAS. ( 0,506730777120283 )
Comput Math Methods Med - A new ratio for protocol categorization. ( 0,505482117958432 )
Res Synth Methods - Robust variance estimation in meta-regression with binary dependent effects. ( 0,503716232467843 )
Spat Spatiotemporal Epidemiol - Characterizing urban vulnerability to heat stress using a spatially varying coefficient model. ( 0,50089598925 )
Comput. Biol. Med. - A ternary model of decompression sickness in rats. ( 0,500444043468889 )
Med Decis Making - Bias associated with failing to incorporate dependence on event history in Markov models. ( 0,500390284296492 )
Neural Comput - The mean time to express synaptic plasticity in integrate-and-express, stochastic models of synaptic plasticity induction. ( 0,498060642832894 )
J. Med. Internet Res. - Maximizing the value of mobile health monitoring by avoiding redundant patient reports: prediction of depression-related symptoms and adherence problems in automated health assessment services. ( 0,497886199578588 )
Med Decis Making - Too much of a good thing? When to stop catch-up vaccination. ( 0,497488563385748 )
Int J Health Geogr - The effects of deprivation and relative deprivation on self-reported morbidity in England: an area-level ecological study. ( 0,49734694673637 )
Appl Clin Inform - Exploring the value of clinical data standards to predict hospitalization of home care patients. ( 0,497332897831561 )
Comput Math Methods Med - Causal information approach to partial conditioning in multivariate data sets. ( 0,49732170005767 )
AMIA Annu Symp Proc - Leveraging derived data elements in data analytic models for understanding and predicting hospital readmissions. ( 0,496816067980088 )
Comput Methods Programs Biomed - The Lindley distribution applied to competing risks lifetime data. ( 0,496430370850683 )
Methods Inf Med - Spatial repolarization heterogeneity and survival in Chagas disease. ( 0,496074059377112 )
J Chem Inf Model - A robust boosting regression tree with applications in quantitative structure-activity relationship studies of organic compounds. ( 0,495845861601569 )
Lifetime Data Anal - Applying competing risks regression models: an overview. ( 0,494959471655277 )
Neural Comput - ParceLiNGAM: a causal ordering method robust against latent confounders. ( 0,494875484665319 )
Spat Spatiotemporal Epidemiol - Spatial-temporal analysis of non-Hodgkin lymphoma risk using multiple residential locations. ( 0,49471456680893 )
Med Decis Making - The influence of graphic display format on the interpretations of quantitative risk information among adults with lower education and literacy: a randomized experimental study. ( 0,49206096386151 )
BMC Med Inform Decis Mak - Automated systems to identify relevant documents in product risk management. ( 0,490492038892689 )
J Clin Monit Comput - Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation. ( 0,490241667309979 )
Med Decis Making - Strategies for efficient computation of the expected value of partial perfect information. ( 0,489766070340548 )
Methods Inf Med - Combining cross-sectional data on prevalence with risk estimates from a prediction model. A novel method for estimating the attributable risk. ( 0,489577734643034 )
Int J Health Geogr - Application of satellite precipitation data to analyse and model arbovirus activity in the tropics. ( 0,486296939624845 )
Spat Spatiotemporal Epidemiol - Assessment of land use factors associated with dengue cases in Malaysia using Boosted Regression Trees. ( 0,485853650838631 )
Med Decis Making - Do different methods of modeling statin treatment effectiveness influence the optimal decision? ( 0,485830856950792 )
Lifetime Data Anal - Evidence synthesis through a degradation model applied to myocardial infarction. ( 0,484616956426315 )
Med Decis Making - The Impact of Uncertainty in Barrett's Esophagus Progression Rates on Hypothetical Screening and Treatment Decisions. ( 0,48357210903845 )
Med Decis Making - Predictive Modeling of Implantation Outcome in an In Vitro Fertilization Setting: An Application of Machine Learning Methods. ( 0,483443692874399 )
Lifetime Data Anal - Semiparametric additive marginal regression models for multiple type recurrent events. ( 0,483405000354198 )
Neural Comput - Reliability of information-based integration of EEG and fMRI data: a simulation study. ( 0,483133784050107 )
Brief. Bioinformatics - On the validity of time-dependent AUC estimators. ( 0,482911591916285 )
IEEE Trans Pattern Anal Mach Intell - Scaling Multidimensional Inference for Structured Gaussian Processes. ( 0,482863331679197 )
Lifetime Data Anal - Predictive comparison of joint longitudinal-survival modeling: a case study illustrating competing approaches. ( 0,482533015317966 )
Comput Methods Programs Biomed - PSHREG: a SAS macro for proportional and nonproportional subdistribution hazards regression. ( 0,482335450546705 )
BMC Med Inform Decis Mak - Predicting sample size required for classification performance. ( 0,48199236278096 )
J Am Med Inform Assoc - Usability-driven pruning of large ontologies: the case of SNOMED CT. ( 0,481888848968109 )
Comput Biol Chem - A more accurate relationship between 'effective number of codons' and GC3s under assumptions of no selection. ( 0,480929496601423 )
Appl Clin Inform - A Computerized Alert Screening for Severe Sepsis in Emergency Department Patients Increases Lactate Testing but does not Improve Inpatient Mortality. ( 0,480255708756931 )
Neural Comput - Optimizing time histograms for non-Poissonian spike trains. ( 0,479681857366751 )
J Biomed Inform - An empirical approach to model selection through validation for censored survival data. ( 0,478674132645823 )
Methods Inf Med - Limited sampling strategies to estimate the area under the concentration-time curve. Biases and a proposed more accurate method. ( 0,476742978497429 )
Brief. Bioinformatics - Ranking prognosis markers in cancer genomic studies. ( 0,476450616625669 )
Res Synth Methods - Combining the evidence using stable weights. ( 0,476045533757124 )
Comput Methods Programs Biomed - EPILEPSIAE - a European epilepsy database. ( 0,476006025370901 )
Lifetime Data Anal - Event dependent sampling of recurrent events. ( 0,475981577709454 )
J Med Syst - Evaluation of kidney transplantation programmes using system simulation. ( 0,4756059302278 )
Lifetime Data Anal - Maximum likelihood analysis of semicompeting risks data with semiparametric regression models. ( 0,475402720866359 )
Int J Health Geogr - A spatial and temporal analysis of notifiable gastrointestinal illness in the Northwest Territories, Canada, 1991-2008. ( 0,474995729402882 )
Spat Spatiotemporal Epidemiol - Modeling habitat suitability for occurrence of highly pathogenic avian influenza virus H5N1 in domestic poultry in Asia: a spatial multicriteria decision analysis approach. ( 0,474850210290861 )
Med Biol Eng Comput - Adapting source grid parameters to improve the condition of the magnetostatic linear inverse problem of estimating nanoparticle distributions. ( 0,47410699699635 )
BMC Med Inform Decis Mak - A data-driven epidemiological prediction method for dengue outbreaks using local and remote sensing data. ( 0,472444080725099 )
Med Decis Making - Whose costs and benefits? Why economic evaluations should simulate both prevalent and all future incident patient cohorts. ( 0,472097944965707 )
Med Decis Making - Development of an EORTC-8D utility algorithm for Sri Lanka. ( 0,471882822703715 )
Methods Inf Med - Reliability of in-hospital mortality as a quality indicator in clinical quality registries. A case study in an intensive care quality register. ( 0,471828929896983 )
Lifetime Data Anal - Quantifying the average of the time-varying hazard ratio via a class of transformations. ( 0,471784635929282 )
AMIA Annu Symp Proc - Disease propagation analysis and mitigation strategies for effective mass dispensing. ( 0,470281497081555 )
Comput Methods Programs Biomed - NPHMC: an R-package for estimating sample size of proportional hazards mixture cure model. ( 0,469725388975094 )
Methods Inf Med - Regularization for generalized additive mixed models by likelihood-based boosting. ( 0,469709528228668 )