Methods Inf Med - Slow adaptation of ventricular repolarization as a cause of arrhythmia?

Tópicos

{ activ(1138) subject(705) human(624) }
{ control(1307) perform(991) simul(935) }
{ blood(1257) pressur(1144) flow(957) }
{ algorithm(1844) comput(1787) effici(935) }
{ high(1669) rate(1365) level(1280) }
{ model(2220) cell(1177) simul(1124) }
{ first(2504) two(1366) second(1323) }
{ chang(1828) time(1643) increas(1301) }
{ data(1714) softwar(1251) tool(1186) }
{ activ(1452) weight(1219) physic(1104) }
{ studi(2440) review(1878) systemat(933) }
{ concept(1167) ontolog(924) domain(897) }
{ research(1085) discuss(1038) issu(1018) }
{ spatial(1525) area(1432) region(1030) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ data(2317) use(1299) case(1017) }
{ signal(2180) analysi(812) frequenc(800) }
{ analysi(2126) use(1163) compon(1037) }
{ result(1111) use(1088) new(759) }
{ sequenc(1873) structur(1644) protein(1328) }
{ take(945) account(800) differ(722) }
{ framework(1458) process(801) describ(734) }
{ care(1570) inform(1187) nurs(1089) }
{ studi(1119) effect(1106) posit(819) }
{ model(3480) simul(1196) paramet(876) }
{ age(1611) year(1155) adult(843) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ model(2656) set(1616) predict(1553) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

TRODUCTION: This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems".BACKGROUND: Adaptation of the QT-interval to changes in heart rate reflects on the body-surface electrocardiogram the adaptation of action potential duration (APD) at the cellular level. The initial fast phase of APD adaptation has been shown to modulate the arrhythmia substrate. Whether the slow phase is potentially proarrhythmic remains unclear.OBJECTIVES: To analyze in-vivo human data and use computer simulations to examine effects of the slow APD adaptation phase on dispersion of repolarization and reentry in the human ventricle.METHODS: Electrograms were acquired from 10 left and 10 right ventricle (LV/RV) endocardial sites in 15 patients with normal ventricles during RV pacing. Activation-recovery intervals, as a surrogate for APD, were measured during a sustained increase in heart rate. Observed dynamics were studied using computer simulations of human tissue electrophysiology.RESULTS: Spatial heterogeneity of rate adaptation was observed in all patients. Inhomogeneity in slow APD adaptation time constants (t(s)) was greater in LV than RV (t(s)(LV) = 31.8 ? 13.2, t(s)(RV) = 19.0 ? 12.8 s, P< 0.01). Simulations showed that altering local slow time constants of adaptation was sufficient to convert partial wavefront block to block with successful reentry.CONCLUSIONS: Using electrophysiological data acquired in-vivo in human and computer simulations, we identify heterogeneity in the slow phase of APD adaptation as an important component of arrhythmogenesis.

Resumo Limpo

troduct articl part focus theme method inform medicin biosign interpret advanc method studi cardiovascular respiratori systemsbackground adapt qtinterv chang heart rate reflect bodysurfac electrocardiogram adapt action potenti durat apd cellular level initi fast phase apd adapt shown modul arrhythmia substrat whether slow phase potenti proarrhythm remain unclearobject analyz invivo human data use comput simul examin effect slow apd adapt phase dispers repolar reentri human ventriclemethod electrogram acquir left right ventricl lvrv endocardi site patient normal ventricl rv pace activationrecoveri interv surrog apd measur sustain increas heart rate observ dynam studi use comput simul human tissu electrophysiologyresult spatial heterogen rate adapt observ patient inhomogen slow apd adapt time constant ts greater lv rv tslv tsrv s p simul show alter local slow time constant adapt suffici convert partial wavefront block block success reentryconclus use electrophysiolog data acquir invivo human comput simul identifi heterogen slow phase apd adapt import compon arrhythmogenesi

Resumos Similares

Comput. Biol. Med. - Evaluation of different stimulation and measurement patterns based on internal electrode: application in cardiac impedance tomography. ( 0,806552993639537 )
Comput. Biol. Med. - Simulation of the microscopic process during initiation of stent thrombosis. ( 0,76424408194026 )
Med Biol Eng Comput - Axial head rotation increases facet joint capsular ligament strains in automotive rear impact. ( 0,726969790107657 )
J Clin Monit Comput - Quantification of the proportion of motor neurons recruited by transcranial electrical stimulation during intraoperative motor evoked potential monitoring. ( 0,724163393410357 )
J Clin Monit Comput - Response entropy changes after noxius stimulus. ( 0,72291402507714 )
Med Biol Eng Comput - Deformation and pressure propagation in deep tissue during mechanical painful pressure stimulation. ( 0,721796083726975 )
J Clin Monit Comput - Muscle relaxant use during intraoperative neurophysiologic monitoring. ( 0,71133513298461 )
Med Biol Eng Comput - Measuring skin conductance over clothes. ( 0,70909503474675 )
Comput Math Methods Med - Virtual grasping: closed-loop force control using electrotactile feedback. ( 0,706347267775971 )
Comput Math Methods Med - The application of computer musculoskeletal modeling and simulation to investigate compressive tibiofemoral force and muscle functions in obese children. ( 0,68642365635339 )
Med Biol Eng Comput - Conduction block of whole nerve without onset firing using combined high frequency and direct current. ( 0,679392616690441 )
Med Biol Eng Comput - Effects of muscle fibre shortening on the characteristics of surface motor unit potentials. ( 0,6732257699134 )
Comput Methods Programs Biomed - Effects of virtual environment platforms on emotional responses. ( 0,672937188200022 )
J Clin Monit Comput - Augmentation of motor evoked potentials using multi-train transcranial electrical stimulation in intraoperative neurophysiologic monitoring during spinal surgery. ( 0,670316209192031 )
Comput. Biol. Med. - Modeling gender effects on electrical activity of single ventricular myocytes. ( 0,67008890362099 )
Methods Inf Med - Extraction of response waveforms of heartbeat and blood pressure to swallowing. Using mixed signal processing of time domain and respiratory phase domain. ( 0,670031679095572 )
Med Biol Eng Comput - The influence of skeletal muscle anisotropy on electroporation: in vivo study and numerical modeling. ( 0,668195702750003 )
Comput Methods Programs Biomed - Adaptive control of a pressure-controlled artificial ventilator: a simulator-based evaluation using real COPD patient data. ( 0,665165608097176 )
Comput Methods Programs Biomed - Computer simulation of MHD blood conveying gold nanoparticles as a third grade non-Newtonian nanofluid in a hollow porous vessel. ( 0,663298186652395 )
Comput. Biol. Med. - Simulating a dual-array electrode configuration to investigate the influence of skeletal muscle fatigue following functional electrical stimulation. ( 0,661972971727283 )
IEEE J Biomed Health Inform - sEMG-based joint force control for an upper-limb power-assist exoskeleton robot. ( 0,656287353170063 )
J Clin Monit Comput - Detection of changes in muscle oxygen saturation in the human leg: a comparison of two near-infrared spectroscopy devices. ( 0,655039171507704 )
Comput Methods Programs Biomed - Development/global validation of a 6-month-old pediatric head finite element model and application in investigation of drop-induced infant head injury. ( 0,653494252641503 )
Med Biol Eng Comput - Safety of multi-channel stimulation implants: a single blocking capacitor per channel is not sufficient after single-fault failure. ( 0,653274579918488 )
Med Biol Eng Comput - Effect of membrane properties on skeletal muscle fiber excitability: a sensitivity analysis. ( 0,648649304898973 )
Int J Comput Assist Radiol Surg - fMRI assessment of upper extremity related brain activation with an MRI-compatible manipulandum. ( 0,647498471894817 )
Comput Math Methods Med - Numerical simulations of MREIT conductivity imaging for brain tumor detection. ( 0,646665174410171 )
Comput Math Methods Med - Optimisation of a generic ionic model of cardiac myocyte electrical activity. ( 0,646108201527274 )
Med Biol Eng Comput - Electrical stimulation for the suppression of pathological tremor. ( 0,644416640697802 )
Med Biol Eng Comput - Optimal chest compression in cardiopulmonary resuscitation depends upon thoracic and back support stiffness. ( 0,643584912192276 )
Med Biol Eng Comput - Estimating nerve excitation thresholds to cutaneous electrical stimulation by finite element modeling combined with a stochastic branching nerve fiber model. ( 0,641364141796566 )
Med Biol Eng Comput - Is it possible to detect dendrite currents using presently available magnetic resonance imaging techniques? ( 0,640586234060894 )
Med Biol Eng Comput - Towards the development of a novel experimental shoulder simulator with rotating scapula and individually controlled muscle forces simulating the rotator cuff. ( 0,637347399175911 )
Int J Neural Syst - The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats. ( 0,63660014158005 )
Comput Math Methods Med - Human atrial cell models to analyse haemodialysis-related effects on cardiac electrophysiology: work in progress. ( 0,636194217990035 )
Comput Math Methods Med - Modiolus-hugging intracochlear electrode array with shape memory alloy. ( 0,636083458144485 )
J Clin Monit Comput - A model-based decision support system for critiquing mechanical ventilation treatments. ( 0,63606868217103 )
Med Biol Eng Comput - Synthesis of optimal electrical stimulation patterns for functional motion restoration: applied to spinal cord-injured patients. ( 0,635825992520882 )
Neural Comput - Intracellular dynamics of virtual place cells. ( 0,634650857710699 )
Comput Methods Programs Biomed - Performance optimization of current focusing and virtual electrode strategies in retinal implants. ( 0,634589505273953 )
Med Biol Eng Comput - Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model. ( 0,633412819399654 )
Med Biol Eng Comput - Advanced biofeedback from surface electromyography signals using fuzzy system. ( 0,632631266127913 )
Comput Math Methods Med - Application of computational lower extremity model to investigate different muscle activities and joint force patterns in knee osteoarthritis patients during walking. ( 0,632218134179227 )
Med Biol Eng Comput - Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function. ( 0,626158530141623 )
Med Biol Eng Comput - Effects of a carotid covered stent with a novel membrane design on the blood flow regime and hemodynamic parameters distribution at the carotid artery bifurcation. ( 0,623894413178333 )
Comput Math Methods Med - Optimisation of ionic models to fit tissue action potentials: application to 3D atrial modelling. ( 0,623816960917938 )
Comput. Biol. Med. - Predicting neointimal hyperplasia in stented arteries using time-dependant computational fluid dynamics: a review. ( 0,623150673082872 )
Med Biol Eng Comput - Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling. ( 0,623049287605852 )
Comput Math Methods Med - Spreading out muscle mass within a Hill-type model: a computer simulation study. ( 0,622716952554261 )
Comput Math Methods Med - Trial-by-trial adaptation of movements during mental practice under force field. ( 0,621789187868103 )
Int J Neural Syst - Computational modeling of transcranial direct current stimulation in the child brain: implications for the treatment of refractory childhood focal epilepsy. ( 0,621462060062756 )
Comput. Biol. Med. - Field distribution of epidural electrical stimulation. ( 0,62076796998363 )
Med Biol Eng Comput - Glenohumeral stability during a hand-positioning task in previously injured shoulders. ( 0,61999807526643 )
J Clin Monit Comput - The influence of gender, hand dominance, and upper extremity length on motor evoked potentials. ( 0,618967895652536 )
Med Biol Eng Comput - Development and validation of a pressure-type automated quantitative sensory testing system for point-of-care pain assessment. ( 0,6178997559801 )
Comput Methods Programs Biomed - Change of short-term memory effect in acute ischemic ventricular myocardium: a computational study. ( 0,617868004611481 )
J Clin Monit Comput - Spinal cord injury from electrocautery: observations in a porcine model using electromyography and motor evoked potentials. ( 0,616585024355404 )
Int J Neural Syst - Electrophysiological responses from vagus nerve stimulation in rats. ( 0,615471316394957 )
Comput Methods Programs Biomed - A passive movement method for parameter estimation of a musculo-skeletal arm model incorporating a modified hill muscle model. ( 0,614488045328174 )
Med Biol Eng Comput - Experimentally validated three-dimensional finite element model of the rat for mild traumatic brain injury. ( 0,61271752974442 )
Med Biol Eng Comput - Peculiarities of extracellular potentials produced by deep muscles. Part 1: single fibre potential fields. ( 0,612582057867162 )
Med Biol Eng Comput - Simulation of the complex countermovement jumping by means of a simple four-degrees-of-freedom model. ( 0,611909047975536 )
Comput. Biol. Med. - Muscle activity detection in electromyograms recorded during periodic movements. ( 0,610672829923262 )
J Med Syst - The effect of an auxiliary stimulation on motor function restoration by FES. ( 0,609695032797837 )
Med Biol Eng Comput - A novel five degree of freedom user command controller in people with spinal cord injury and non-injured for full upper extremity neuroprostheses, wearable powered orthoses and prosthetics. ( 0,609324684230447 )
Comput. Aided Surg. - Kinematics and laxity of a linked total elbow arthroplasty following computer navigated implant positioning. ( 0,608016857754889 )
Med Biol Eng Comput - Effect of head posture on the healthy human carotid bifurcation hemodynamics. ( 0,607707690528277 )
Comput Math Methods Med - Noninvasive measurement of conductivity anisotropy at larmor frequency using MRI. ( 0,607456217161173 )
Med Biol Eng Comput - The effect of local anatomy on the electric field induced by TMS: evaluation at 14 different target sites. ( 0,606306640642699 )
Med Biol Eng Comput - Spinal cord direct current stimulation: finite element analysis of the electric field and current density. ( 0,605037532081869 )
J Clin Monit Comput - Impact of central hypovolemia on photoplethysmographic waveform parameters in healthy volunteers. Part 1: time domain analysis. ( 0,604637018006773 )
Med Biol Eng Comput - Effect of arm position on the prediction of kinematics from EMG in amputees. ( 0,603859639855542 )
Methods Inf Med - Surface and intramural reentrant patterns during atrial fibrillation in the sheep. ( 0,602220263398675 )
Med Biol Eng Comput - Energy harvesting through arterial wall deformation: design considerations for a magneto-hydrodynamic generator. ( 0,601242651319011 )
Comput. Biol. Med. - Empirical modeling of renal motion for improved targeting during focused ultrasound surgery. ( 0,600861203941337 )
Med Biol Eng Comput - Non-linear adaptive controllers for an over-actuated pneumatic MR-compatible stepper. ( 0,600135127303505 )
Neural Comput - Dynamic analysis of naive adaptive brain-machine interfaces. ( 0,599537458165235 )
Comput Math Methods Med - The strength-interval curve in cardiac tissue. ( 0,595263675168582 )
Comput Methods Programs Biomed - Motor adaptation with passive machines: a first study on the effect of real and virtual stiffness. ( 0,594316172085422 )
Comput. Biol. Med. - Complex activity patterns in arterial wall: results from a model of calcium dynamics. ( 0,593784457806732 )
Med Biol Eng Comput - A method for determination of muscle fiber diameter using single fiber potential (SFP) analysis. ( 0,593443380268739 )
J Med Syst - Functional and mechanical evaluation of nerve stretch injury. ( 0,592968926647732 )
IEEE J Biomed Health Inform - Inverse estimation of multiple muscle activations from joint moment with muscle synergy extraction. ( 0,591991341991342 )
Comput. Biol. Med. - Shivering heat production and body fat protect the core from cooling during body immersion, but not during head submersion: a structural equation model. ( 0,590912528955625 )
Comput. Aided Surg. - A biomechanical study regarding the effect of tissue harvesting from the thorax on its movement during inspiration. ( 0,590037254604058 )
Med Biol Eng Comput - Cranial translation of the humeral head on radiographs in rotator cuff tear patients: the modified active abduction view. ( 0,588796311708129 )
Med Biol Eng Comput - Brain hypothermia induced by cold spinal fluid using a torso cooling pad: theoretical analyses. ( 0,587756311573675 )
Neural Comput - A detailed and fast model of extracellular recordings. ( 0,585688806112807 )
Med Biol Eng Comput - The consequences of the mechanical environment of peripheral arteries for nitinol stenting. ( 0,584924283940126 )
Med Biol Eng Comput - Where does transcranial magnetic stimulation (TMS) stimulate? Modelling of induced field maps for some common cortical and cerebellar targets. ( 0,583180957697024 )
Med Biol Eng Comput - Estimation of elbow flexion force during isometric muscle contraction from mechanomyography and electromyography. ( 0,582681446694518 )
Med Biol Eng Comput - Sensory data fusion of pressure mattress and wireless inertial magnetic measurement units. ( 0,580982085032248 )
IEEE J Biomed Health Inform - Effect of cadence regulation on muscle activation patterns during robot assisted gait: a dynamic simulation study. ( 0,580202953177516 )
Wiley Interdiscip Rev Syst Biol Med - Mechanisms of memory enhancement. ( 0,579851571078808 )
IEEE J Biomed Health Inform - Invariant Surface EMG Feature Against Varying Contraction Level for Myoelectric Control Based on Muscle Coordination. ( 0,579845575285168 )
Comput Methods Programs Biomed - A simulation of T-wave alternans vectocardiographic representation performed by changing the ventricular heart cells action potential duration. ( 0,577450029404697 )
Comput Math Methods Med - An approach for simulation of the muscle force modeling it by summation of motor unit contraction forces. ( 0,576574325596074 )
Comput Methods Programs Biomed - Viscoelastic model based force control for soft tissue interaction and its application in physiological motion compensation. ( 0,576490614271547 )
J Clin Monit Comput - Monitoring of intense neuromuscular blockade in a pig model. ( 0,576229680371156 )
Med Biol Eng Comput - Influence of the instrumented force shoe on gait pattern in patients with osteoarthritis of the knee. ( 0,575197766001074 )