Methods Inf Med - Location tests for biomarker studies: a comparison using simulations for the two-sample case.

Tópicos

{ spatial(1525) area(1432) region(1030) }
{ clinic(1479) use(1117) guidelin(835) }
{ visual(1396) interact(850) tool(830) }
{ model(3404) distribut(989) bayesian(671) }
{ error(1145) method(1030) estim(1020) }
{ data(3963) clinic(1234) research(1004) }
{ sampl(1606) size(1419) use(1276) }
{ sequenc(1873) structur(1644) protein(1328) }
{ take(945) account(800) differ(722) }
{ model(2220) cell(1177) simul(1124) }
{ use(1733) differ(960) four(931) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ perform(999) metric(946) measur(919) }
{ blood(1257) pressur(1144) flow(957) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ studi(2440) review(1878) systemat(933) }
{ treatment(1704) effect(941) patient(846) }
{ framework(1458) process(801) describ(734) }
{ chang(1828) time(1643) increas(1301) }
{ method(1557) propos(1049) approach(1037) }
{ general(901) number(790) one(736) }
{ howev(809) still(633) remain(590) }
{ risk(3053) factor(974) diseas(938) }
{ system(1050) medic(1026) inform(1018) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ analysi(2126) use(1163) compon(1037) }
{ high(1669) rate(1365) level(1280) }
{ process(1125) use(805) approach(778) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ studi(1410) differ(1259) use(1210) }
{ research(1085) discuss(1038) issu(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

CKGROUND: Gene, protein, or metabolite expression levels are often non-normally distributed, heavy tailed and contain outliers. Standard statistical approaches may fail as location tests in this situation.OBJECTIVES: In three Monte-Carlo simulation studies, we aimed at comparing the type I error levels and empirical power of standard location tests and three adaptive tests [O'Gorman, Can J Stat 1997; 25: 269-279; Keselman et al., Brit J Math Stat Psychol 2007; 60: 267-293; Szymczak et al., Stat Med 2013; 32: 524-537] for a wide range of distributions.METHODS: We simulated two-sample scenarios using the g-and-k-distribution family to systematically vary tail length and skewness with identical and varying variability between groups.RESULTS: All tests kept the type I error level when groups did not vary in their variability. The standard non-parametric U-test performed well in all simulated scenarios. It was outperformed by the two non-parametric adaptive methods in case of heavy tails or large skewness. Most tests did not keep the type I error level for skewed data in the case of heterogeneous variances.CONCLUSIONS: The standard U-test was a powerful and robust location test for most of the simulated scenarios except for very heavy tailed or heavy skewed data, and it is thus to be recommended except for these cases. The non-parametric adaptive tests were powerful for both normal and non-normal distributions under sample variance homogeneity. But when sample variances differed, they did not keep the type I error level. The parametric adaptive test lacks power for skewed and heavy tailed distributions.

Resumo Limpo

ckground gene protein metabolit express level often nonnorm distribut heavi tail contain outlier standard statist approach may fail locat test situationobject three montecarlo simul studi aim compar type error level empir power standard locat test three adapt test ogorman can j stat keselman et al brit j math stat psychol szymczak et al stat med wide rang distributionsmethod simul twosampl scenario use gandkdistribut famili systemat vari tail length skew ident vari variabl groupsresult test kept type error level group vari variabl standard nonparametr utest perform well simul scenario outperform two nonparametr adapt method case heavi tail larg skew test keep type error level skew data case heterogen variancesconclus standard utest power robust locat test simul scenario except heavi tail heavi skew data thus recommend except case nonparametr adapt test power normal nonnorm distribut sampl varianc homogen sampl varianc differ keep type error level parametr adapt test lack power skew heavi tail distribut

Resumos Similares

Int J Health Geogr - A high resolution spatial population database of Somalia for disease risk mapping. ( 0,736972468751349 )
Spat Spatiotemporal Epidemiol - Violent crime in San Antonio, Texas: an application of spatial epidemiological methods. ( 0,714150220477315 )
Int J Health Geogr - Hand, foot and mouth disease: spatiotemporal transmission and climate. ( 0,675438611281383 )
Int J Health Geogr - Density estimation and adaptive bandwidths: a primer for public health practitioners. ( 0,663219243752927 )
Neural Comput - Optimal population codes for space: grid cells outperform place cells. ( 0,656879912376827 )
Int J Health Geogr - Pathogenic landscapes: interactions between land, people, disease vectors, and their animal hosts. ( 0,651182356593344 )
Int J Health Geogr - Smart density: A more accurate method of measuring rural residential density for health-related research. ( 0,64566513087399 )
Int J Health Geogr - Adjusting for sampling variability in sparse data: geostatistical approaches to disease mapping. ( 0,644772025409425 )
Int J Health Geogr - Relevance of the type III error in epidemiological maps. ( 0,641541377850347 )
Int J Health Geogr - Does context matter for the relationship between deprivation and all-cause mortality? The West vs. the rest of Scotland. ( 0,64088111468871 )
J Integr Bioinform - Inter-dinucleotide distances in the human genome: an analysis of the whole-genome and protein-coding distributions. ( 0,632159684570029 )
Int J Health Geogr - Nonparametric intensity bounds for the delineation of spatial clusters. ( 0,630412122045376 )
Int J Health Geogr - Spatial distribution and cluster analysis of sexual risk behaviors reported by young men in Kisumu, Kenya. ( 0,630031208948066 )
Spat Spatiotemporal Epidemiol - How to choose geographical units in ecological studies: proposal and application to campylobacteriosis. ( 0,628728718726459 )
Spat Spatiotemporal Epidemiol - Error propagation models to examine the effects of geocoding quality on spatial analysis of individual-level datasets. ( 0,625273844616697 )
Int J Health Geogr - Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars. ( 0,624765341174947 )
Int J Health Geogr - The effect of spatial aggregation on performance when mapping a risk of disease. ( 0,624228326227064 )
Int J Health Geogr - Mapping HIV clustering: a strategy for identifying populations at high risk of HIV infection in sub-Saharan Africa. ( 0,622572316493488 )
Int J Health Geogr - A probabilistic sampling method (PSM) for estimating geographic distance to health services when only the region of residence is known. ( 0,619863922441442 )
Int J Health Geogr - Identifying landscape features associated with Rift Valley fever virus transmission, Ferlo region, Senegal, using very high spatial resolution satellite imagery. ( 0,61683047063011 )
Int J Health Geogr - A novel tool for assessing and summarizing the built environment. ( 0,616114289424963 )
J Biomed Inform - Enhancing phylogeography by improving geographical information from GenBank. ( 0,616110316614631 )
Spat Spatiotemporal Epidemiol - Adjusted significance cutoffs for hypothesis tests applied with generalized additive models with bivariate smoothers. ( 0,614397652671134 )
Spat Spatiotemporal Epidemiol - Using geographical information systems and cartograms as a health service quality improvement tool. ( 0,614153871490837 )
Spat Spatiotemporal Epidemiol - Statistical methods for bivariate spatial analysis in marked points. Examples in spatial epidemiology. ( 0,613878336995126 )
Spat Spatiotemporal Epidemiol - The rubber plantation environment and Lassa fever epidemics in Liberia, 2008-2012: a spatial regression. ( 0,61267885174484 )
Int J Health Geogr - Modeling the spatial distribution of Chagas disease vectors using environmental variables and people?s knowledge. ( 0,612669514936215 )
Spat Spatiotemporal Epidemiol - Estimating the effects of environmental exposures using a weighted mean of monitoring stations. ( 0,610297479578414 )
Comput Biol Chem - DNA clustering and genome complexity. ( 0,609518034110461 )
Int J Health Geogr - Alcohol outlets and clusters of violence. ( 0,607263190328464 )
Int J Health Geogr - Modelling the variation of land surface temperature as determinant of risk of heat-related health events. ( 0,603443490349309 )
Spat Spatiotemporal Epidemiol - A comparison of conditional autoregressive models used in Bayesian disease mapping. ( 0,603138643908864 )
Int J Health Geogr - A country bug in the city: urban infestation by the Chagas disease vector Triatoma infestans in Arequipa, Peru. ( 0,602270439455464 )
Int J Health Geogr - Outdoor air pollution, subtypes and severity of ischemic stroke--a small-area level ecological study. ( 0,601360662017961 )
Int J Health Geogr - Spatial epidemiology of eastern equine encephalitis in Florida. ( 0,601110895254055 )
Int J Health Geogr - Enabling methods for community health mapping in developing countries. ( 0,599128588452714 )
Spat Spatiotemporal Epidemiol - Quantifying the magnitude of environmental exposure misclassification when using imprecise address proxies in public health research. ( 0,597053609863863 )
Int J Health Geogr - A modified version of Moran's I. ( 0,595229673314138 )
Int J Health Geogr - A spatial approach for the epidemiology of antibiotic use and resistance in community-based studies: the emergence of urban clusters of Escherichia coli quinolone resistance in Sao Paulo, Brasil. ( 0,59384198198488 )
Spat Spatiotemporal Epidemiol - Spatio-temporal epidemiology: principles and opportunities. ( 0,593341530944891 )
Int J Health Geogr - Developing the atlas of cancer in Queensland: methodological issues. ( 0,592848415557616 )
Sci Data - Systematic global assessment of reef fish communities by the Reef Life Survey program. ( 0,591607978309962 )
Int J Health Geogr - Data-driven inference for the spatial scan statistic. ( 0,590878228459849 )
Int J Health Geogr - A ubiquitous method for street scale spatial data collection and analysis in challenging urban environments: mapping health risks using spatial video in Haiti. ( 0,590797599180379 )
Int J Health Geogr - Schistosomiasis transmission and environmental change: a spatio-temporal analysis in Porto de Galinhas, Pernambuco--Brazil. ( 0,590195657700605 )
Int J Health Geogr - Including the urban heat island in spatial heat health risk assessment strategies: a case study for Birmingham, UK. ( 0,589700790953875 )
Int J Health Geogr - A systematic review of the application and utility of geographical information systems for exploring disease-disease relationships in paediatric global health research: the case of anaemia and malaria. ( 0,588667545405346 )
Int J Health Geogr - The effects of local street network characteristics on the positional accuracy of automated geocoding for geographic health studies. ( 0,587350358206691 )
Int J Health Geogr - Demarcation of local neighborhoods to study relations between contextual factors and health. ( 0,585213416576797 )
Int J Health Geogr - Ecological niche modelling of Hemipteran insects in Cameroon; the paradox of a vector-borne transmission for Mycobacterium ulcerans, the causative agent of Buruli ulcer. ( 0,581693968177811 )
Int J Health Geogr - A geographic analysis of population density thresholds in the influenza pandemic of 1918-19. ( 0,576905499020739 )
Int J Health Geogr - Agricultural landscape and spatial distribution of Toxoplasma gondii in rural environment: an agent-based model. ( 0,575804045959682 )
Int J Health Geogr - Characterizing the interface between wild ducks and poultry to evaluate the potential of transmission of avian pathogens. ( 0,575749343534357 )
Int J Health Geogr - Diarrheal disease risk in rural Bangladesh decreases as tubewell density increases: a zero-inflated and geographically weighted analysis. ( 0,575407508392143 )
Int J Health Geogr - Retrospective space-time analysis of H5N1 Avian Influenza emergence in Thailand. ( 0,575052404318924 )
Int J Health Geogr - Performance map of a cluster detection test using extended power. ( 0,574980713696293 )
Spat Spatiotemporal Epidemiol - The built environment and depressive symptoms among urban youth: A spatial regression study. ( 0,574851911418464 )
Int J Health Geogr - Urban sprawl, obesity, and cancer mortality in the United States: cross-sectional analysis and methodological challenges. ( 0,573884057801793 )
Spat Spatiotemporal Epidemiol - Spatio-temporal modeling of the African swine fever epidemic in the Russian Federation, 2007-2012. ( 0,572424804250316 )
Int J Health Geogr - International variation in neighborhood walkability, transit, and recreation environments using geographic information systems: the IPEN adult study. ( 0,570840380917123 )
Int J Health Geogr - Highways and outposts: economic development and health threats in the central Brazilian Amazon region. ( 0,569681768578479 )
Int J Health Geogr - Global spatiotemporal and genetic footprint of the H5N1 avian influenza virus. ( 0,56522925322887 )
Int J Health Geogr - Does the choice of neighbourhood supermarket access measure influence associations with individual-level fruit and vegetable consumption? A case study from Glasgow. ( 0,564174523343209 )
Spat Spatiotemporal Epidemiol - Racial residential segregation impacts on low birth weight using improved neighborhood boundary definitions. ( 0,564053285246425 )
Int J Health Geogr - Is temperature the main cause of dengue rise in non-endemic countries? The case of Argentina. ( 0,56346138597843 )
Int J Health Geogr - Estimating the reproductive number in the presence of spatial heterogeneity of transmission patterns. ( 0,561841503247407 )
Int J Health Geogr - How do changes to the built environment influence walking behaviors? A longitudinal study within a university campus in Hong Kong. ( 0,561057824371846 )
Int J Health Geogr - Analyzing spatial aggregation error in statistical models of late-stage cancer risk: a Monte Carlo simulation approach. ( 0,560362326609186 )
J Chem Inf Model - Electron density distribution in endohedral complexes of fullerene C60, calculated based on the Gauss law. ( 0,560073903515948 )
Int J Health Geogr - Can a deprivation index be used legitimately over both urban and rural areas? ( 0,559124555551148 )
Spat Spatiotemporal Epidemiol - Visualizing health data with micromaps. ( 0,557901769727243 )
Int J Health Geogr - Terra and Aqua satellites track tiger mosquito invasion: modelling the potential distribution of Aedes albopictus in north-eastern Italy. ( 0,557483202136229 )
Int J Health Geogr - Racial differences in the built environment--body mass index relationship? A geospatial analysis of adolescents in urban neighborhoods. ( 0,557439212994119 )
Spat Spatiotemporal Epidemiol - Prostate cancer incidence in light of the spatial distribution of another screening-detectable cancer. ( 0,555470078894452 )
Int J Health Geogr - An open source software for fast grid-based data-mining in spatial epidemiology (FGBASE). ( 0,554650598769676 )
Comput Methods Programs Biomed - Development of PK- and PBPK-based modeling tools for derivation of biomonitoring guidance values. ( 0,554447838536701 )
J Med Syst - A small-area study of environmental risk assessment of outdoor falls. ( 0,55357086848994 )
Int J Health Geogr - Enhancing spatial detection accuracy for syndromic surveillance with street level incidence data. ( 0,553436386590796 )
J. Comput. Biol. - CNVeM: copy number variation detection using uncertainty of read mapping. ( 0,552251744051393 )
Int J Health Geogr - Spatial-explicit modeling of social vulnerability to malaria in East Africa. ( 0,551935789899131 )
Int J Health Geogr - Comparing multilevel and Bayesian spatial random effects survival models to assess geographical inequalities in colorectal cancer survival: a case study. ( 0,551502920835692 )
Int J Health Geogr - Zoom in at African country level: potential climate induced changes in areas of suitability for survival of malaria vectors. ( 0,550854156445058 )
Int J Health Geogr - Mapping heatwave health risk at the community level for public health action. ( 0,547983563274775 )
Int J Health Geogr - Identification and location of hot and cold spots of treated prevalence of depression in Catalonia (Spain). ( 0,547724940614103 )
Int J Health Geogr - Potential corridors and barriers for plague spread in Central Asia. ( 0,547047925245409 )
Int J Health Geogr - Spatial patterns of fetal loss and infant death in an arsenic-affected area in Bangladesh. ( 0,544257138937228 )
Spat Spatiotemporal Epidemiol - Generalizing the spatial relative risk function. ( 0,543288717515188 )
Int J Health Geogr - The spatial distribution of esophageal and gastric cancer in Caspian region of Iran: an ecological analysis of diet and socio-economic influences. ( 0,542855643587256 )
Spat Spatiotemporal Epidemiol - Measuring the spatial accuracy of the spatial scan statistic. ( 0,542762899508955 )
J Chem Inf Model - Aggregation properties of a polymeric anticancer therapeutic: a coarse-grained modeling study. ( 0,542530326533661 )
Spat Spatiotemporal Epidemiol - Residential address errors in public health surveillance data: a description and analysis of the impact on geocoding. ( 0,542224729477427 )
Spat Spatiotemporal Epidemiol - Spatial error in geocoding physician location data from the AMA Physician Masterfile: implications for spatial accessibility analysis. ( 0,541876150364892 )
Int J Health Geogr - Creating 'obesogenic realities'; do our methodological choices make a difference when measuring the food environment? ( 0,541838119616427 )
Spat Spatiotemporal Epidemiol - Statistical power of disease cluster and clustering tests for rare diseases: a simulation study of point sources. ( 0,541615990747123 )
Int J Health Geogr - Web-based GIS: the vector-borne disease airline importation risk (VBD-AIR) tool. ( 0,540706383636018 )
Int J Health Geogr - Particulate air pollution and health inequalities: a Europe-wide ecological analysis. ( 0,540195718598417 )
Int J Health Geogr - Feasibility and utility of mapping disease risk at the neighbourhood level within a Canadian public health unit: an ecological study. ( 0,540076366483351 )
Int J Health Geogr - Mapping amyotrophic lateral sclerosis lake risk factors across northern New England. ( 0,539070707976442 )
Int J Health Geogr - Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada. ( 0,537391314014339 )
Int J Health Geogr - Using GPS technology to (re)-examine operational definitions of 'neighbourhood' in place-based health research. ( 0,536758913069513 )