Methods Inf Med - An evolutionary approach to realism-based adverse event representations.

Tópicos

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Resumo

CKGROUND: Part of the ReMINE project involved the creation of an ontology enabling computer-assisted decision support for optimal adverse event management.OBJECTIVES: The ontology was required to satisfy the following requirements: 1) to be able to account for the distinct and context-dependent ways in which authoritative sources define the term 'adverse event', 2) to allow the identification of relevant risks against patient safety (RAPS) on the basis of the disease history of a patient as documented in electronic health records, and 3) to be compatible with present and future ontologies developed under the Open Biomedical Ontology (OBO) Foundry framework.METHODS: We used as feeder ontologies the Basic Formal Ontology, the Foundational Model of Anatomy, the Ontology for General Medical Science, the Information Artifact Ontology and the Ontology of Mental Health. We further used relations defined according to the pattern set forth in the OBO Relation Ontology. In light of the intended use of the ontology for the representation of adverse events that have actually occurred and therefore are registered in a database, we also applied the principles of referent tracking.RESULTS: We merged the upper portions of the mentioned feeder ontologies and introduced 22 additional representational units of which 13 are generally applicable in biomedicine and nine in the adverse event context. We provided for each representational unit a textual definition that can be translated into equivalent formal definitions.CONCLUSION: The resulting ontology satisfies all of the requirements set forth. Merging the feeder ontologies, although all designed under the OBO Foundry principles, brought new insight into what the representational units of such ontologies actually denote.

Resumo Limpo

ckground part remin project involv creation ontolog enabl computerassist decis support optim advers event managementobject ontolog requir satisfi follow requir abl account distinct contextdepend way authorit sourc defin term advers event allow identif relev risk patient safeti rap basi diseas histori patient document electron health record compat present futur ontolog develop open biomed ontolog obo foundri frameworkmethod use feeder ontolog basic formal ontolog foundat model anatomi ontolog general medic scienc inform artifact ontolog ontolog mental health use relat defin accord pattern set forth obo relat ontolog light intend use ontolog represent advers event actual occur therefor regist databas also appli principl refer trackingresult merg upper portion mention feeder ontolog introduc addit represent unit general applic biomedicin nine advers event context provid represent unit textual definit can translat equival formal definitionsconclus result ontolog satisfi requir set forth merg feeder ontolog although design obo foundri principl brought new insight represent unit ontolog actual denot

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