Methods Inf Med - Omics-based medicine and systems pathology. A new perspective for personalized and predictive medicine.

Tópicos

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{ take(945) account(800) differ(722) }
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{ model(2656) set(1616) predict(1553) }
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{ data(3008) multipl(1320) sourc(1022) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ motion(1329) object(1292) video(1091) }
{ framework(1458) process(801) describ(734) }
{ chang(1828) time(1643) increas(1301) }
{ research(1085) discuss(1038) issu(1018) }
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{ survey(1388) particip(1329) question(1065) }
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{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

JECTIVES: Recent important advances in the human genomics and post-genomic "omics" are now bringing about a new medical care which we call "omics-based medicine". In this article, we investigated the development and future possibilities of omics-based medicine.METHODS: We divided the development of omics-based medicine into three generations in order to clarify the main clinical goals and characteristics of informatics method of each generation, together with its future possibilities.RESULTS: The first generation of omics-based medicine started with "genomic medicine" based on the inborn individual differences of genome. It has opened the study of genetic polymorphism of the diseases and promoted the personalized medication based on the pharmacogenetic/pharmacogenomic difference of the drug response. In the second generation of omics-based medicine, owing to the advances in the high-throughput technology, vast amount of the various post-genomic disease omics data containing comprehensive molecular information of diseased somatic cells has become available. It reflects the ongoing state of diseases more closely and enables the predictive medicine such as prognosis prediction of disease by applying the data-driven analysis. Finally, due to the rapidly growing knowledge about the cellular molecular network, system-level understanding of the disease, called systems pathology, becomes possible. It can fully exploit the substantial contents of disease omics and will lead to a comprehensive understanding of disease process by using model-driven analysis.CONCLUSION: Omics-based medicine and systems pathology will realize a new personalized and predictive medicine.

Resumo Limpo

jectiv recent import advanc human genom postgenom omic now bring new medic care call omicsbas medicin articl investig develop futur possibl omicsbas medicinemethod divid develop omicsbas medicin three generat order clarifi main clinic goal characterist informat method generat togeth futur possibilitiesresult first generat omicsbas medicin start genom medicin base inborn individu differ genom open studi genet polymorph diseas promot person medic base pharmacogeneticpharmacogenom differ drug respons second generat omicsbas medicin owe advanc highthroughput technolog vast amount various postgenom diseas omic data contain comprehens molecular inform diseas somat cell becom avail reflect ongo state diseas close enabl predict medicin prognosi predict diseas appli datadriven analysi final due rapid grow knowledg cellular molecular network systemlevel understand diseas call system patholog becom possibl can fulli exploit substanti content diseas omic will lead comprehens understand diseas process use modeldriven analysisconclus omicsbas medicin system patholog will realiz new person predict medicin

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