Methods Inf Med - Segmented Poincar? plot analysis for risk stratification in patients with dilated cardiomyopathy.

Tópicos

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Resumo

CKGROUND: The prognostic value of heart rate variability in patients with dilated cardiomyopathy (DCM) is limited and does not contribute to risk stratification although the dynamics of ventricular repolarization differs considerably between DCM patients and healthy subjects. Neither linear nor nonlinear methods of heart rate variability analysis could discriminate between patients at high and low risk for sudden cardiac death.OBJECTIVE: The aim of this study was to analyze the suitability of the new developed segmented Poincar? plot analysis (SPPA) to enhance risk stratification in DCM.METHODS: In contrast to the usual applied Poincar? plot analysis the SPPA retains nonlinear features from investigated beat-to-beat interval time series. Main features of SPPA are the rotation of cloud of points and their succeeded variability depended segmentation.RESULTS: Significant row and column probabilities were calculated from the segments and led to discrimination (up to p<0.005) between low and high risk in DCM patients.CONCLUSION: For the first time an index from Poincar? plot analysis of heart rate variability was able to contribute to risk stratification in patients suffering from DCM.

Resumo Limpo

ckground prognost valu heart rate variabl patient dilat cardiomyopathi dcm limit contribut risk stratif although dynam ventricular repolar differ consider dcm patient healthi subject neither linear nonlinear method heart rate variabl analysi discrimin patient high low risk sudden cardiac deathobject aim studi analyz suitabl new develop segment poincar plot analysi sppa enhanc risk stratif dcmmethod contrast usual appli poincar plot analysi sppa retain nonlinear featur investig beattobeat interv time seri main featur sppa rotat cloud point succeed variabl depend segmentationresult signific row column probabl calcul segment led discrimin p low high risk dcm patientsconclus first time index poincar plot analysi heart rate variabl abl contribut risk stratif patient suffer dcm

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