Neural Comput - The role of extracellular conductivity profiles in compartmental models for neurons: particulars for layer 5 pyramidal cells.

Tópicos

{ activ(1138) subject(705) human(624) }
{ network(2748) neural(1063) input(814) }
{ model(2220) cell(1177) simul(1124) }
{ estim(2440) model(1874) function(577) }
{ drug(1928) target(777) effect(648) }
{ research(1218) medic(880) student(794) }
{ method(1969) cluster(1462) data(1082) }
{ take(945) account(800) differ(722) }
{ state(1844) use(1261) util(961) }
{ featur(1941) imag(1645) propos(1176) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ model(3480) simul(1196) paramet(876) }
{ analysi(2126) use(1163) compon(1037) }
{ model(3404) distribut(989) bayesian(671) }
{ studi(2440) review(1878) systemat(933) }
{ error(1145) method(1030) estim(1020) }
{ visual(1396) interact(850) tool(830) }
{ spatial(1525) area(1432) region(1030) }
{ data(3008) multipl(1320) sourc(1022) }
{ use(1733) differ(960) four(931) }
{ result(1111) use(1088) new(759) }
{ activ(1452) weight(1219) physic(1104) }
{ method(2212) result(1239) propos(1039) }
{ measur(2081) correl(1212) valu(896) }
{ method(1219) similar(1157) match(930) }
{ assess(1506) score(1403) qualiti(1306) }
{ framework(1458) process(801) describ(734) }
{ concept(1167) ontolog(924) domain(897) }
{ data(1714) softwar(1251) tool(1186) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ studi(1410) differ(1259) use(1210) }
{ research(1085) discuss(1038) issu(1018) }
{ import(1318) role(1303) understand(862) }
{ studi(1119) effect(1106) posit(819) }
{ monitor(1329) mobil(1314) devic(1160) }
{ data(2317) use(1299) case(1017) }
{ survey(1388) particip(1329) question(1065) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ motion(1329) object(1292) video(1091) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ general(901) number(790) one(736) }
{ search(2224) databas(1162) retriev(909) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ ehr(2073) health(1662) electron(1139) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

With the rapid increase in the number of technologies aimed at observing electric activity inside the brain, scientists have felt the urge to create proper links between intracellular- and extracellular-based experimental approaches. Biophysical models at both physical scales have been formalized under assumptions that impede the creation of such links. In this work, we address this issue by proposing a multicompartment model that allows the introduction of complex extracellular and intracellular resistivity profiles. This model accounts for the geometrical and electrotonic properties of any type of neuron through the combination of four devices: the integrator, the propagator, the 3D connector, and the collector. In particular, we applied this framework to model the tufted pyramidal cells of layer 5 (PCL5) in the neocortex. Our model was able to reproduce the decay and delay curves of backpropagating action potentials (APs) in this type of cell with better agreement with experimental data. We used the voltage drops of the extracellular resistances at each compartment to approximate the local field potentials generated by a PCL5 located in close proximity to linear microelectrode arrays. Based on the voltage drops produced by backpropagating APs, we were able to estimate the current multipolar moments generated by a PCL5. By adding external current sources in parallel to the extracellular resistances, we were able to create a sensitivity profile of PCL5 to electric current injections from nearby microelectrodes. In our model for PCL5, the kinetics and spatial profile of each ionic current were determined based on a literature survey, and the geometrical properties of these cells were evaluated experimentally. We concluded that the inclusion of the extracellular space in the compartmental models of neurons as an extra electrotonic medium is crucial for the accurate simulation of both the propagation of the electric potentials along the neuronal dendrites and the neuronal reactivity to an electrical stimulation using external microelectrodes.

Resumo Limpo

rapid increas number technolog aim observ electr activ insid brain scientist felt urg creat proper link intracellular extracellularbas experiment approach biophys model physic scale formal assumpt imped creation link work address issu propos multicompart model allow introduct complex extracellular intracellular resist profil model account geometr electroton properti type neuron combin four devic integr propag d connector collector particular appli framework model tuft pyramid cell layer pcl neocortex model abl reproduc decay delay curv backpropag action potenti ap type cell better agreement experiment data use voltag drop extracellular resist compart approxim local field potenti generat pcl locat close proxim linear microelectrod array base voltag drop produc backpropag ap abl estim current multipolar moment generat pcl ad extern current sourc parallel extracellular resist abl creat sensit profil pcl electr current inject nearbi microelectrod model pcl kinet spatial profil ionic current determin base literatur survey geometr properti cell evalu experiment conclud inclus extracellular space compartment model neuron extra electroton medium crucial accur simul propag electr potenti along neuron dendrit neuron reactiv electr stimul use extern microelectrod

Resumos Similares

Neural Comput - A detailed and fast model of extracellular recordings. ( 0,731096009940011 )
Med Biol Eng Comput - Neural oscillators triggered by loading and hip orientation can generate activation patterns at the ankle during walking in humans. ( 0,693494778574515 )
Med Biol Eng Comput - Empirical quantification of internal and external rotation muscular co-activation ratios in healthy shoulders. ( 0,67723706163491 )
Med Biol Eng Comput - Evaluation of muscle force classification using shape analysis of the sEMG probability density function: a simulation study. ( 0,658019332652148 )
Med Biol Eng Comput - Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces. ( 0,657270079274086 )
Comput. Biol. Med. - Simulating a dual-array electrode configuration to investigate the influence of skeletal muscle fatigue following functional electrical stimulation. ( 0,656799715777105 )
Comput Math Methods Med - Application of computational lower extremity model to investigate different muscle activities and joint force patterns in knee osteoarthritis patients during walking. ( 0,656400474105413 )
Comput Math Methods Med - An approach for simulation of the muscle force modeling it by summation of motor unit contraction forces. ( 0,646581914212876 )
Med Biol Eng Comput - Optical monitoring of neural networks evoked by focal electrical stimulation on microelectrode arrays using FM dyes. ( 0,640751825548536 )
Med Biol Eng Comput - A cable theory based biophysical model of resistance change in crab peripheral nerve and human cerebral cortex during neuronal depolarisation: implications for electrical impedance tomography of fast neural activity in the brain. ( 0,639361377770061 )
Med Biol Eng Comput - Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling. ( 0,636828707198169 )
Med Biol Eng Comput - Predicted effects of pulse width programming in spinal cord stimulation: a mathematical modeling study. ( 0,631469787973702 )
Med Biol Eng Comput - Sensorimotor cortical response during motion reflecting audiovisual stimulation: evidence from fractal EEG analysis. ( 0,629818521382458 )
Comput. Biol. Med. - Role of intracellular calcium dynamics in the short-term memory in CVM model: a simulation study. ( 0,624732968020259 )
Med Biol Eng Comput - Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation. ( 0,619372135528306 )
Comput. Biol. Med. - Estimation of saline-mixed tissue conductivity and ablation lesion size. ( 0,61788358663153 )
Comput Math Methods Med - Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study. ( 0,616044107258871 )
Med Biol Eng Comput - Transmembrane potential generated by a magnetically induced transverse electric field in a cylindrical axonal model. ( 0,614188190634709 )
Comput. Biol. Med. - Simulation of the microscopic process during initiation of stent thrombosis. ( 0,606940236056568 )
Med Biol Eng Comput - The effect of local anatomy on the electric field induced by TMS: evaluation at 14 different target sites. ( 0,605462493024004 )
Comput Math Methods Med - Spreading out muscle mass within a Hill-type model: a computer simulation study. ( 0,60157495117182 )
IEEE Trans Vis Comput Graph - Visualization and Analysis of Vortex-Turbine Intersections in Wind Farms. ( 0,588936219268569 )
Comput Methods Programs Biomed - Development/global validation of a 6-month-old pediatric head finite element model and application in investigation of drop-induced infant head injury. ( 0,58815874537282 )
Med Biol Eng Comput - The influence of skeletal muscle anisotropy on electroporation: in vivo study and numerical modeling. ( 0,58735639964039 )
Med Biol Eng Comput - Mixed-signal template-based reduction scheme for stimulus artifact removal in electrical stimulation. ( 0,587253414264036 )
Comput. Biol. Med. - Anatomic and electro-physiologic connectivity of the language system: a combined DTI-CCEP study. ( 0,586462905228897 )
Med Biol Eng Comput - Estimation of flexible needle deflection in layered soft tissues with different elastic moduli. ( 0,586264763816544 )
Comput Methods Programs Biomed - Drug release profile in core-shell nanofibrous structures: a study on Peppas equation and artificial neural network modeling. ( 0,585972891161413 )
Neural Comput - Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity. ( 0,585199542045265 )
Comput Methods Programs Biomed - Feedback controlled electrical nerve stimulation: a computer simulation. ( 0,584980660142767 )
Neural Comput - Intracellular dynamics of virtual place cells. ( 0,584866917423356 )
Neural Comput - Self-organization of topographic bilinear networks for invariant recognition. ( 0,584565633016991 )
J Clin Monit Comput - A simple model of the right atrium of the human heart with the sinoatrial and atrioventricular nodes included. ( 0,583672946243211 )
Med Biol Eng Comput - Towards the development of a novel experimental shoulder simulator with rotating scapula and individually controlled muscle forces simulating the rotator cuff. ( 0,581994313571343 )
Comput Math Methods Med - The robotic lumbar spine: dynamics and feedback linearization control. ( 0,580660548803795 )
Med Biol Eng Comput - Spinal cord direct current stimulation: finite element analysis of the electric field and current density. ( 0,580572163811789 )
Int J Neural Syst - A new linear muscle fiber model for neural control of saccades. ( 0,580386973208375 )
Med Biol Eng Comput - Estimation of elbow flexion force during isometric muscle contraction from mechanomyography and electromyography. ( 0,578246916726524 )
Neural Comput - Population coding and the labeling problem: extrinsic versus intrinsic representations. ( 0,577074452231137 )
Comput Methods Programs Biomed - Performance optimization of current focusing and virtual electrode strategies in retinal implants. ( 0,572917229807128 )
Comput Methods Programs Biomed - A passive movement method for parameter estimation of a musculo-skeletal arm model incorporating a modified hill muscle model. ( 0,572535533839273 )
Neural Comput - The mean time to express synaptic plasticity in integrate-and-express, stochastic models of synaptic plasticity induction. ( 0,572514182545766 )
Med Biol Eng Comput - Improved numerical approach for electrical modeling of biological cell clusters. ( 0,571026322266859 )
Neural Comput - Regulation of ambient GABA levels by neuron-glia signaling for reliable perception of multisensory events. ( 0,570173079694583 )
Neural Comput - Spontaneous slow oscillations and sequential patterns due to short-term plasticity in a model of the cortex. ( 0,569469474898083 )
Comput Math Methods Med - Optimisation of ionic models to fit tissue action potentials: application to 3D atrial modelling. ( 0,5680578969392 )
Comput Methods Programs Biomed - Independent complexity patterns in single neuron activity induced by static magnetic field. ( 0,565719391670436 )
Lifetime Data Anal - Matched survival data in a co-twin control design. ( 0,56432318597177 )
Res Synth Methods - Network meta-analysis, electrical networks and graph theory. ( 0,56421756921234 )
Comput Math Methods Med - Noninvasive measurement of conductivity anisotropy at larmor frequency using MRI. ( 0,563733073702343 )
Neural Comput - Emergence of optimal decoding of population codes through STDP. ( 0,561593599890709 )
Med Biol Eng Comput - Estimating nerve excitation thresholds to cutaneous electrical stimulation by finite element modeling combined with a stochastic branching nerve fiber model. ( 0,561332276788606 )
Neural Comput - Facilitation of neuronal responses by intrinsic default mode network activity. ( 0,560511681052886 )
Neural Comput - Motor cortex microcircuit simulation based on brain activity mapping. ( 0,559907275432773 )
J Med Syst - Functional and mechanical evaluation of nerve stretch injury. ( 0,558152877855284 )
Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model. ( 0,554603443984896 )
Comput Math Methods Med - Statistical analysis of single-trial Granger causality spectra. ( 0,554044659235012 )
Comput Math Methods Med - Modeling the chemoelectromechanical behavior of skeletal muscle using the parallel open-source software library OpenCMISS. ( 0,553262971439417 )
Neural Comput - Predicting single-neuron activity in locally connected networks. ( 0,553180636483735 )
Comput Math Methods Med - Three-dimensional lower extremity joint loading in a carved ski and snowboard turn: a pilot study. ( 0,552009045954679 )
Neural Comput - Movement duration, Fitts's law, and an infinite-horizon optimal feedback control model for biological motor systems. ( 0,551283934324272 )
Comput. Aided Surg. - Kinematics and laxity of a linked total elbow arthroplasty following computer navigated implant positioning. ( 0,549690845365087 )
Comput Math Methods Med - The influence of the specimen shape and loading conditions on the parameter identification of a viscoelastic brain model. ( 0,548879628935473 )
Comput Math Methods Med - Effect of Pilates training on alpha rhythm. ( 0,546817416907838 )
Int J Neural Syst - A gray-box neural network-based model identification and fault estimation scheme for nonlinear dynamic systems. ( 0,545362570992134 )
Neural Comput - Model-based decoding, information estimation, and change-point detection techniques for multineuron spike trains. ( 0,545320024040463 )
Neural Comput - Synchronization and redundancy: implications for robustness of neural learning and decision making. ( 0,544064088680248 )
Med Biol Eng Comput - Extracting the parameters of the double-dispersion Cole bioimpedance model from magnitude response measurements. ( 0,542399158887615 )
Med Biol Eng Comput - The analysis of forces needed for the suturing of elliptical skin wounds. ( 0,541601934712114 )
Int J Neural Syst - A new work mechanism on neuronal activity. ( 0,541463687042027 )
Comput. Biol. Med. - Effects of degenerated intervertebral discs on intersegmental rotations, intradiscal pressures, and facet joint forces of the whole lumbar spine. ( 0,54103429661918 )
Comput. Biol. Med. - Modeling gender effects on electrical activity of single ventricular myocytes. ( 0,539780797768692 )
Comput. Biol. Med. - Drug perfusion enhancement in tissue model by steady streaming induced by oscillating microbubbles. ( 0,539447972993908 )
Med Biol Eng Comput - A method for determination of muscle fiber diameter using single fiber potential (SFP) analysis. ( 0,53797771402115 )
Comput. Biol. Med. - Design, analysis and verification of a knee joint oncological prosthesis finite element model. ( 0,537649459061672 )
IEEE J Biomed Health Inform - Robust automatic measurement of 3D scanned models for the human body fat estimation. ( 0,537391954579157 )
Neural Comput - Approximate emergent synchrony in spatially coupled spiking neurons with discrete interaction. ( 0,537126904071459 )
Int J Med Robot - Anatomical evaluation and stress distribution of intact canine femur. ( 0,535166540566323 )
Med Biol Eng Comput - Spatiotemporal scales and links between electrical neuroimaging modalities. ( 0,534432352725005 )
Comput Math Methods Med - The effect of inhibitory neuron on the evolution model of higher-order coupling neural oscillator population. ( 0,533799405564649 )
Med Biol Eng Comput - Intraoperative forces and moments analysis on patient head clamp during awake brain surgery. ( 0,532528361788992 )
Med Biol Eng Comput - Sensitivity of hip tissues contact evaluation to the methods used for estimating the hip joint center of rotation. ( 0,530906353103456 )
J Clin Monit Comput - Spinal cord injury from electrocautery: observations in a porcine model using electromyography and motor evoked potentials. ( 0,530702447874398 )
Neural Comput - Subthreshold membrane depolarization as memory trace for perceptual learning. ( 0,530544328516101 )
Neural Comput - ROC-based estimates of neural-behavioral covariations using matched filters. ( 0,530492185224557 )
Med Biol Eng Comput - Deformation and pressure propagation in deep tissue during mechanical painful pressure stimulation. ( 0,530396564154489 )
Int J Neural Syst - Electrophysiological responses from vagus nerve stimulation in rats. ( 0,529818714502858 )
Med Biol Eng Comput - A quasi-brittle continuum damage finite element model of the human proximal femur based on element deletion. ( 0,529626779389878 )
Int J Neural Syst - Understanding Networks of Computing Chemical Droplet Neurons Based on Information Flow. ( 0,529069927114844 )
Neural Comput - Estimating parameters of generalized integrate-and-fire neurons from the maximum likelihood of spike trains. ( 0,528787481197203 )
Neural Comput - Revisiting tests for neglected nonlinearity using artificial neural networks. ( 0,528667798410742 )
Med Biol Eng Comput - Where does transcranial magnetic stimulation (TMS) stimulate? Modelling of induced field maps for some common cortical and cerebellar targets. ( 0,528071775732332 )
J Chem Inf Model - Engineering antimicrobial peptides with improved antimicrobial and hemolytic activities. ( 0,527937784188593 )
Comput. Aided Surg. - A biomechanical study regarding the effect of tissue harvesting from the thorax on its movement during inspiration. ( 0,526996981484232 )
Neural Comput - Synaptic scaling stabilizes persistent activity driven by asynchronous neurotransmitter release. ( 0,526185606599118 )
Comput Math Methods Med - The strength-interval curve in cardiac tissue. ( 0,523834306459522 )
IEEE J Biomed Health Inform - Inverse estimation of multiple muscle activations from joint moment with muscle synergy extraction. ( 0,523222608640772 )
IEEE Trans Image Process - A generalized logarithmic image processing model based on the gigavision sensor model. ( 0,522633196885622 )
Int J Neural Syst - Efficacy of a new charge-balanced biphasic electrical stimulus in the isolated sciatic nerve and the hippocampal slice. ( 0,522053230971342 )
Neural Comput - Information-geometric measures for estimation of connection weight under correlated inputs. ( 0,521733722884362 )