Neural Comput - Molecular diffusion model of neurotransmitter homeostasis around synapses supporting gradients.

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Resumo

Neurotransmitter homeostasis in and around a synapse involves complex random processes such as diffusion, molecular binding, and uptake by glial transporters. A three-dimensional stochastic diffusion model of a synapse was developed to provide molecular-level details of neurotransmitter homeostasis not predicted by alternative models based on continuum approaches. The development was illustrated through an example case cortico-accumbens synapse that successfully integrated neuroadaptations observed after chronic cocaine. By incorporating cystine-glutamate exchanger as a nonsynaptic release site for glutamate, the stochastic model was used to quantify the relative contributions of synaptic and nonsynaptic sources to extracellular concentration and to estimate molecular influx rates into the perisynapse. A perturbation analysis showed that among the parameters considered, variation in surface density of glial transporters had the largest effect on glutamate concentrations. The stochastic diffusion model of the example synapse was further generalized to characterize glial morphology by studying the role of diffusion path length in supporting neurotransmitter gradients and isolating the synapse. For the same set of parameters, diffusion path length was found to be proportional to the gradient supported.

Resumo Limpo

neurotransmitt homeostasi around synaps involv complex random process diffus molecular bind uptak glial transport threedimension stochast diffus model synaps develop provid molecularlevel detail neurotransmitt homeostasi predict altern model base continuum approach develop illustr exampl case corticoaccumben synaps success integr neuroadapt observ chronic cocain incorpor cystineglutam exchang nonsynapt releas site glutam stochast model use quantifi relat contribut synapt nonsynapt sourc extracellular concentr estim molecular influx rate perisynaps perturb analysi show among paramet consid variat surfac densiti glial transport largest effect glutam concentr stochast diffus model exampl synaps general character glial morpholog studi role diffus path length support neurotransmitt gradient isol synaps set paramet diffus path length found proport gradient support

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