Neural Comput - Distinguishing the causes of firing with the membrane potential slope.

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Resumo

In this letter, we aim to measure the relative contribution of coincidence detection and temporal integration to the firing of spikes of a simple neuron model. To this end, we develop a method to infer the degree of synchrony in an ensemble of neurons whose firing drives a single postsynaptic cell. This is accomplished by studying the effects of synchronous inputs on the membrane potential slope of the neuron and estimating the degree of response-relevant input synchrony, which determines the neuron's operational mode. The measure is calculated using the normalized slope of the membrane potential prior to the spikes fired by a neuron, and we demonstrate that it is able to distinguish between the two operational modes. By applying this measure to the membrane potential time course of a leaky integrate-and-fire neuron with the partial somatic reset mechanism, which has been shown to be the most likely candidate to reflect the mechanism used in the brain for reproducing the highly irregular firing at high rates, we show that the partial reset model operates as a temporal integrator of incoming excitatory postsynaptic potentials and that coincidence detection is not necessary for producing such high irregular firing.

Resumo Limpo

letter aim measur relat contribut coincid detect tempor integr fire spike simpl neuron model end develop method infer degre synchroni ensembl neuron whose fire drive singl postsynapt cell accomplish studi effect synchron input membran potenti slope neuron estim degre responserelev input synchroni determin neuron oper mode measur calcul use normal slope membran potenti prior spike fire neuron demonstr abl distinguish two oper mode appli measur membran potenti time cours leaki integrateandfir neuron partial somat reset mechan shown like candid reflect mechan use brain reproduc high irregular fire high rate show partial reset model oper tempor integr incom excitatori postsynapt potenti coincid detect necessari produc high irregular fire

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