Neural Comput - Subthreshold membrane depolarization as memory trace for perceptual learning.

Tópicos

{ network(2748) neural(1063) input(814) }
{ model(2220) cell(1177) simul(1124) }
{ spatial(1525) area(1432) region(1030) }
{ can(774) often(719) complex(702) }
{ compound(1573) activ(1297) structur(1058) }
{ treatment(1704) effect(941) patient(846) }
{ high(1669) rate(1365) level(1280) }
{ chang(1828) time(1643) increas(1301) }
{ import(1318) role(1303) understand(862) }
{ drug(1928) target(777) effect(648) }
{ control(1307) perform(991) simul(935) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ system(1050) medic(1026) inform(1018) }
{ record(1888) medic(1808) patient(1693) }
{ gene(2352) biolog(1181) express(1162) }
{ data(1737) use(1416) pattern(1282) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ data(1714) softwar(1251) tool(1186) }
{ search(2224) databas(1162) retriev(909) }
{ case(1353) use(1143) diagnosi(1136) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ ehr(2073) health(1662) electron(1139) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ detect(2391) sensit(1101) algorithm(908) }
{ model(3404) distribut(989) bayesian(671) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }

Resumo

Experience-dependent synaptic plasticity characterizes the adaptable brain and is believed to be the cellular substrate for perceptual learning. A chemical agent such as gamma-aminobutyric acid (GABA) is known to affect synaptic alteration, perhaps gating perceptual learning. We examined whether and how ambient (extrasynaptic) GABA affects experience-dependent synaptic alteration. A cortical neural network model was simulated. Transporters on GABAergic interneurons regulate ambient GABA levels around their axonal target neurons by removing GABA from (forward transport) or releasing it into (reverse transport) the extracellular space. The ambient GABA provides neurons with tonic inhibitory currents by activating extrasynaptic GABA(a) receptors. During repeated exposures to the same stimulus, we modified the synaptic connection strength between principal cells in a spike-timing-dependent manner. This modulated the activity of GABAergic interneurons, and reduced or augmented ambient GABA concentration. Reduction in ambient GABA concentration led to slight depolarization (less than several millivolts) in ongoing-spontaneous membrane potential. This was a subthreshold neuronal behavior because ongoing-spontaneous spiking activity remained almost unchanged. The ongoing-spontaneous subthreshold depolarization improved a suprathreshold neuronal response. If the stimulus was long absent for perceptual learning, augmentation of ambient GABA concentration took place and the ongoing-spontaneous subthreshold depolarization was depressed. We suggest that a perceptual memory trace could be left in neuronal circuitry as an ongoing-spontaneous subthreshold membrane depolarization, which would allow that memory to be accessed easily afterward, whereas a trace of a memory that has not recently been retrieved fades away when the ongoing-spontaneous subthreshold membrane depolarization built by previous perceptual learning is depressed. This would lead that memory to be accessed with some difficulty. In the brain, ambient GABA, whose level could be regulated by transporter may have an important role in leaving memory trace for perceptual learning.

Resumo Limpo

experiencedepend synapt plastic character adapt brain believ cellular substrat perceptu learn chemic agent gammaaminobutyr acid gaba known affect synapt alter perhap gate perceptu learn examin whether ambient extrasynapt gaba affect experiencedepend synapt alter cortic neural network model simul transport gabaerg interneuron regul ambient gaba level around axon target neuron remov gaba forward transport releas revers transport extracellular space ambient gaba provid neuron tonic inhibitori current activ extrasynapt gabaa receptor repeat exposur stimulus modifi synapt connect strength princip cell spiketimingdepend manner modul activ gabaerg interneuron reduc augment ambient gaba concentr reduct ambient gaba concentr led slight depolar less sever millivolt ongoingspontan membran potenti subthreshold neuron behavior ongoingspontan spike activ remain almost unchang ongoingspontan subthreshold depolar improv suprathreshold neuron respons stimulus long absent perceptu learn augment ambient gaba concentr took place ongoingspontan subthreshold depolar depress suggest perceptu memori trace left neuron circuitri ongoingspontan subthreshold membran depolar allow memori access easili afterward wherea trace memori recent retriev fade away ongoingspontan subthreshold membran depolar built previous perceptu learn depress lead memori access difficulti brain ambient gaba whose level regul transport may import role leav memori trace perceptu learn

Resumos Similares

Neural Comput - Facilitation of neuronal responses by intrinsic default mode network activity. ( 0,903649067468854 )
Comput Math Methods Med - Voxel scale complex networks of functional connectivity in the rat brain: neurochemical state dependence of global and local topological properties. ( 0,898239772720821 )
Int J Neural Syst - Modeling fluctuations in default-mode brain network using a spiking neural network. ( 0,870318721419602 )
Neural Comput - Regulation of ambient GABA levels by neuron-glia signaling for reliable perception of multisensory events. ( 0,853224957463014 )
Neural Comput - Neutral stability, rate propagation, and critical branching in feedforward networks. ( 0,851693037962705 )
Neural Comput - Anatomical constraints on lateral competition in columnar cortical architectures. ( 0,850418504866661 )
Neural Comput - Traveling bumps and their collisions in a two-dimensional neural field. ( 0,844093628883034 )
Neural Comput - Fragility in dynamic networks: application to neural networks in the epileptic cortex. ( 0,831463870454613 )
Neural Comput - Motor cortex microcircuit simulation based on brain activity mapping. ( 0,829402333273979 )
Int J Neural Syst - Effects of extremely low-frequency magnetic fields on the response of a conductance-based neuron model. ( 0,827465440365963 )
Neural Comput - Echo state property linked to an input: exploring a fundamental characteristic of recurrent neural networks. ( 0,827397276798984 )
Int J Neural Syst - Adaptation-dependent synchronization transitions and burst generations in electrically coupled neural networks. ( 0,825158534051285 )
Neural Comput - Noise tolerance of attractor and feedforward memory models. ( 0,824557608666671 )
Neural Comput - Dynamical synapses enhance neural information processing: gracefulness, accuracy, and mobility. ( 0,821406607126972 )
Neural Comput - Nearly extensive sequential memory lifetime achieved by coupled nonlinear neurons. ( 0,817872047520349 )
Neural Comput - The competing benefits of noise and heterogeneity in neural coding. ( 0,814411618997562 )
Neural Comput - Influence of external inputs and asymmetry of connections on information-geometric measures involving up to ten neuronal interactions. ( 0,811995135368342 )
Neural Comput - Mechanisms that modulate the transfer of spiking correlations. ( 0,807591760917916 )
Neural Comput - Sparseness, antisparseness and anything in between: the operating point of a neuron determines its computational repertoire. ( 0,807403320642341 )
IEEE Trans Neural Netw Learn Syst - A Spiking Neural Simulator Integrating Event-Driven and Time-Driven Computation Schemes Using Parallel CPU-GPU Co-Processing: A Case Study. ( 0,803574456757273 )
Neural Comput - Spontaneous slow oscillations and sequential patterns due to short-term plasticity in a model of the cortex. ( 0,797605241378461 )
J Chem Inf Model - Modeling complex metabolic reactions, ecological systems, and financial and legal networks with MIANN models based on Markov-Wiener node descriptors. ( 0,796124608260347 )
Neural Comput - Replicating receptive fields of simple and complex cells in primary visual cortex in a neuronal network model with temporal and population sparseness and reliability. ( 0,789633441955905 )
Neural Comput - Natural gradient learning algorithms for RBF networks. ( 0,78875625790442 )
Neural Comput - Analysis of the stabilized supralinear network. ( 0,784200036572322 )
Neural Comput - Self-organization of topographic bilinear networks for invariant recognition. ( 0,783880230775485 )
Neural Comput - Synaptic scaling stabilizes persistent activity driven by asynchronous neurotransmitter release. ( 0,782794738155338 )
Neural Comput - Short-term memory capacity in networks via the restricted isometry property. ( 0,782285983121864 )
Neural Comput - Synchronization and redundancy: implications for robustness of neural learning and decision making. ( 0,780289638731785 )
Neural Comput - Interactions of excitatory and inhibitory feedback topologies in facilitating pattern separation and retrieval. ( 0,780116525532084 )
Neural Comput - Information-geometric measures for estimation of connection weight under correlated inputs. ( 0,779243109888047 )
Int J Neural Syst - A neuron-based time-optimal controller of horizontal saccadic eye movements. ( 0,767334884178675 )
Neural Comput - Neural information processing with feedback modulations. ( 0,76486398588715 )
Neural Comput - Learning rule of homeostatic synaptic scaling: presynaptic dependent or not. ( 0,764449723501164 )
Brief. Bioinformatics - BioFNet: biological functional network database for analysis and synthesis of biological systems. ( 0,761239607936844 )
Neural Comput - Complete classification of the macroscopic behavior of a heterogeneous network of theta neurons. ( 0,760166345399 )
Neural Comput - Projective clustering using neural networks with adaptive delay and signal transmission loss. ( 0,757611357535512 )
Neural Comput - Collective stability of networks of winner-take-all circuits. ( 0,757028762785887 )
Neural Comput - Design strategies for weight matrices of echo state networks. ( 0,756490866933674 )
Neural Comput - Computing with a canonical neural circuits model with pool normalization and modulating feedback. ( 0,756190380270033 )
Neural Comput - Statistical computer model analysis of the reciprocal and recurrent inhibitions of the Ia-EPSP in a-motoneurons. ( 0,754175587849359 )
Neural Comput - Exact event-driven implementation for recurrent networks of stochastic perfect integrate-and-fire neurons. ( 0,753037728231354 )
Neural Comput - Spike-timing-dependent construction. ( 0,75132409526892 )
Comput Math Methods Med - Concentration-invariant odor representation in the olfactory system by presynaptic inhibition. ( 0,750825495945442 )
IEEE Trans Neural Netw Learn Syst - Phase Oscillatory Network and Visual Pattern Recognition. ( 0,747576691348546 )
Neural Comput - A no-go theorem for one-layer feedforward networks. ( 0,747126805753669 )
IEEE Trans Neural Netw Learn Syst - Stability Analysis of Distributed Delay Neural Networks Based on Relaxed Lyapunov-Krasovskii Functionals. ( 0,746600508744912 )
Neural Comput - Intrinsic adaptation in autonomous recurrent neural networks. ( 0,744137864993755 )
Int J Neural Syst - A new work mechanism on neuronal activity. ( 0,743458668679247 )
J Chem Inf Model - New Markov-autocorrelation indices for re-evaluation of links in chemical and biological complex networks used in metabolomics, parasitology, neurosciences, and epidemiology. ( 0,742642560262649 )
Neural Comput - A framework for simulating and estimating the state and functional topology of complex dynamic geometric networks. ( 0,739277851870906 )
Neural Comput - How to compress sequential memory patterns into periodic oscillations: general reduction rules. ( 0,736210075886115 )
Neural Comput - Subdiffusive dynamics of bump attractors: mechanisms and functional roles. ( 0,736197744415279 )
Neural Comput - Neuronal responses below firing threshold for subthreshold cross-modal enhancement. ( 0,735626585541958 )
Comput. Biol. Med. - Discontinuous Galerkin finite element method for solving population density functions of cortical pyramidal and thalamic neuronal populations. ( 0,730793145561869 )
Comput. Biol. Med. - Connectivity analysis of multichannel EEG signals using recurrence based phase synchronization technique. ( 0,730709295657895 )
Int J Neural Syst - Optimal sparse approximation with integrate and fire neurons. ( 0,72972773974562 )
Neural Comput - Chaotic exploration and learning of locomotion behaviors. ( 0,728648550808957 )
Neural Comput - Encoding binary neural codes in networks of threshold-linear neurons. ( 0,727351804753428 )
Comput Math Methods Med - Weighted phase lag index and graph analysis: preliminary investigation of functional connectivity during resting state in children. ( 0,724241788136284 )
Comput Math Methods Med - Analysis of epileptic seizures with complex network. ( 0,724098661713428 )
Neural Comput - Tonically balancing intracortical excitation and inhibition by GABAergic gliotransmission. ( 0,722248651441354 )
Neural Comput - A bayesian model of polychronicity. ( 0,722151915310206 )
IEEE Trans Neural Netw Learn Syst - Properties and Performance of Imperfect Dual Neural Network-Based k WTA Networks. ( 0,721984609786738 )
Neural Comput - Unsupervised formation of vocalization-sensitive neurons: a cortical model based on short-term and homeostatic plasticity. ( 0,716979979775844 )
Int J Neural Syst - Hardware implementation of stochastic spiking neural networks. ( 0,716712975302467 )
Neural Comput - Competition through selective inhibitory synchrony. ( 0,715408789884124 )
Neural Comput - Randomly connected networks have short temporal memory. ( 0,713735447187794 )
Neural Comput - Predicting single-neuron activity in locally connected networks. ( 0,713476777514324 )
Comput Math Methods Med - A signal-processing-based approach to time-varying graph analysis for dynamic brain network identification. ( 0,71342564487104 )
Neural Comput - Formation and regulation of dynamic patterns in two-dimensional spiking neural circuits with spike-timing-dependent plasticity. ( 0,713116423815155 )
Int J Neural Syst - Relationship between applicability of current-based synapses and uniformity of firing patterns. ( 0,713099606780342 )
Neural Comput - Decorrelation by recurrent inhibition in heterogeneous neural circuits. ( 0,713029753973138 )
Neural Comput - Discovering functional neuronal connectivity from serial patterns in spike train data. ( 0,711801796253593 )
Neural Comput - A self-organized artificial neural network architecture for sensory integration with applications to letter-phoneme integration. ( 0,711124905694878 )
Neural Comput - Neuronal assembly dynamics in supervised and unsupervised learning scenarios. ( 0,709048084430464 )
Neural Comput - Transmission of population-coded information. ( 0,705867948105747 )
Comput Methods Programs Biomed - Introducing treatment strategy for cerebellar ataxia in mutant med mice: combination of acetazolamide and 4-aminopyridine. ( 0,705417371910655 )
Neural Comput - Insights from a simple expression for linear fisher information in a recurrently connected population of spiking neurons. ( 0,704179465024474 )
Med Biol Eng Comput - Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces. ( 0,702760707207696 )
Neural Comput - The rise and fall of memory in a model of synaptic integration. ( 0,699347974046204 )
Comput Math Methods Med - Computational models of neuron-astrocyte interactions lead to improved efficacy in the performance of neural networks. ( 0,69814783268668 )
Int J Neural Syst - Perceptual suppression revealed by adaptive multi-scale entropy analysis of local field potential in monkey visual cortex. ( 0,69808977895148 )
Wiley Interdiscip Rev Syst Biol Med - Neural stem and progenitor cells in health and disease. ( 0,695420473480113 )
IEEE Trans Neural Netw Learn Syst - Complex-Valued Recurrent Correlation Neural Networks. ( 0,693797505546745 )
IEEE Trans Neural Netw Learn Syst - A two-layer recurrent neural network for nonsmooth convex optimization problems. ( 0,692853562602031 )
Neural Comput - Multiplicative gain modulation arises through unsupervised learning in a predictive coding model of cortical function. ( 0,692818573532087 )
Neural Comput - A spike-timing-based integrated model for pattern recognition. ( 0,685903466573565 )
Comput Methods Programs Biomed - Characterizing electrical signals evoked by acupuncture through complex network mapping: a new perspective on acupuncture. ( 0,68552135958449 )
IEEE Trans Neural Netw Learn Syst - Exponential Stabilization of Memristor-based Chaotic Neural Networks with Time-Varying Delays via Intermittent Control. ( 0,685174551254233 )
Neural Comput - Tuning low-voltage-activated A-current for silent gain modulation. ( 0,685120325067699 )
Neural Comput - On the performance of voltage stepping for the simulation of adaptive, nonlinear integrate-and-fire neuronal networks. ( 0,684527958188773 )
Neural Comput - Multilayer perceptron classification of unknown volatile chemicals from the firing rates of insect olfactory sensory neurons and its application to biosensor design. ( 0,683355251193133 )
Neural Comput - Frequency selectivity emerging from spike-timing-dependent plasticity. ( 0,682354834396134 )
Comput Math Methods Med - Large-scale modeling of epileptic seizures: scaling properties of two parallel neuronal network simulation algorithms. ( 0,682019815556073 )
IEEE Trans Vis Comput Graph - A Modular Degree-of-Interest Specification for the Visual Analysis of Large Dynamic Networks. ( 0,681345118214905 )
Int J Neural Syst - From sensors to spikes: evolving receptive fields to enhance sensorimotor information in a robot-arm. ( 0,681121514616725 )
Neural Comput - Adaptive optimal control without weight transport. ( 0,677904219171411 )
Wiley Interdiscip Rev Syst Biol Med - Mitochondrial network energetics in the heart. ( 0,677517662961901 )
Neural Comput - Information recall using relative spike timing in a spiking neural network. ( 0,677509773008674 )