Res Synth Methods - Combining study outcome measures using dominance adjusted weights.

Tópicos

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Resumo

Weighting of studies in meta-analysis is usually implemented by using the estimated inverse variances of treatment effect estimates. However, there is a possibility of one study dominating other studies in the estimation process by taking on a weight that is above some upper limit. We implement an estimator of the heterogeneity variance that takes advantage of dominance adjusted weights. The performance of this estimator is compared with that of the commonly used estimator in meta-analysis, the DerSimonian-Laird estimator. Two test procedures for the overall treatment effect are proposed that are based on the quadratic form associated with the proposed heterogeneity variance estimator. An example is given to illustrate the application of these procedures. Copyright ? 2013 John Wiley & Sons, Ltd.

Resumo Limpo

weight studi metaanalysi usual implement use estim invers varianc treatment effect estim howev possibl one studi domin studi estim process take weight upper limit implement estim heterogen varianc take advantag domin adjust weight perform estim compar common use estim metaanalysi dersimonianlaird estim two test procedur overal treatment effect propos base quadrat form associ propos heterogen varianc estim exampl given illustr applic procedur copyright john wiley son ltd

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