Res Synth Methods - Issues relating to study design and risk of bias when including non-randomized studies in systematic reviews on the effects of interventions.

Tópicos

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Resumo

Non-randomized studies may provide valuable evidence on the effects of interventions. They are the main source of evidence on the intended effects of some types of interventions and often provide the only evidence about the effects of interventions on long-term outcomes, rare events or adverse effects. Therefore, systematic reviews on the effects of interventions may include various types of non-randomized studies. In this second paper in a series, we address how review authors might articulate the particular non-randomized study designs they will include and how they might evaluate, in general terms, the extent to which a particular non-randomized study is at risk of important biases. We offer guidance for describing and classifying different non-randomized designs based on specific features of the studies in place of using non-informative study design labels. We also suggest criteria to consider when deciding whether to include non-randomized studies. We conclude that a taxonomy of study designs based on study design features is needed. Review authors need new tools specifically to assess the risk of bias for some non-randomized designs that involve a different inferential logic compared with parallel group trials. Copyright ? 2012 John Wiley & Sons, Ltd.

Resumo Limpo

nonrandom studi may provid valuabl evid effect intervent main sourc evid intend effect type intervent often provid evid effect intervent longterm outcom rare event advers effect therefor systemat review effect intervent may includ various type nonrandom studi second paper seri address review author might articul particular nonrandom studi design will includ might evalu general term extent particular nonrandom studi risk import bias offer guidanc describ classifi differ nonrandom design base specif featur studi place use noninform studi design label also suggest criteria consid decid whether includ nonrandom studi conclud taxonomi studi design base studi design featur need review author need new tool specif assess risk bias nonrandom design involv differ inferenti logic compar parallel group trial copyright john wiley son ltd

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