Res Synth Methods - Synthesis of survival and disease progression outcomes for health technology assessment of cancer therapies.


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Studies of clinical efficacy commonly report more than one clinical endpoint. For example, randomized controlled trials of treatments for cancer will normally report time to disease progression as well as overall survival. It is likely that disease progression will be associated with higher mortality rates. Disease progression rates will also have consequences for the societal economic burden of the disease. Economic evaluation of the cost-effectiveness of different treatment regimes therefore requires the joint estimation of both disease progression and mortality. We describe a model to combine evidence from studies reporting time to event summaries for disease progression and/or mortality, motivated by a systematic review of 1st-line treatment for advanced breast cancer to provide inputs for an economic evaluation as part of the National Institute for Health and Clinical Excellence (NICE) clinical guideline on treatment of advanced breast cancer in England and Wales. The review identified a network of treatment comparisons, which provides the basis for indirect comparison. A variety of outcomes were reported: overall survival, time to progression (overall and responders only), and the proportion of responder, stable, progressive disease, and non-assessable patients. There were only five trials, and not all trials reported all outcomes. The scarcity of the available evidence required us to make strong assumptions in order to identify model parameters. However, this evidence structure often occurs in health technology assessment (HTA) of treatments for cancer. We discuss the validity of the assumptions made, and the potential to assess their validity in other applications of HTA of cancer therapies. Copyright ? 2011 John Wiley & Sons, Ltd.

Resumo Limpo

studi clinic efficaci common report one clinic endpoint exampl random control trial treatment cancer will normal report time diseas progress well overal surviv like diseas progress will associ higher mortal rate diseas progress rate will also consequ societ econom burden diseas econom evalu costeffect differ treatment regim therefor requir joint estim diseas progress mortal describ model combin evid studi report time event summari diseas progress andor mortal motiv systemat review stline treatment advanc breast cancer provid input econom evalu part nation institut health clinic excel nice clinic guidelin treatment advanc breast cancer england wale review identifi network treatment comparison provid basi indirect comparison varieti outcom report overal surviv time progress overal respond proport respond stabl progress diseas nonassess patient five trial trial report outcom scarciti avail evid requir us make strong assumpt order identifi model paramet howev evid structur often occur health technolog assess hta treatment cancer discuss valid assumpt made potenti assess valid applic hta cancer therapi copyright john wiley son ltd

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