Res Synth Methods - Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool.

Tópicos

{ studi(2440) review(1878) systemat(933) }
{ research(1085) discuss(1038) issu(1018) }
{ state(1844) use(1261) util(961) }
{ decis(3086) make(1611) patient(1517) }
{ model(3404) distribut(989) bayesian(671) }
{ analysi(2126) use(1163) compon(1037) }
{ network(2748) neural(1063) input(814) }
{ chang(1828) time(1643) increas(1301) }
{ general(901) number(790) one(736) }
{ gene(2352) biolog(1181) express(1162) }
{ health(1844) social(1437) communiti(874) }
{ data(1737) use(1416) pattern(1282) }
{ clinic(1479) use(1117) guidelin(835) }
{ control(1307) perform(991) simul(935) }
{ patient(2837) hospit(1953) medic(668) }
{ group(2977) signific(1463) compar(1072) }
{ inform(2794) health(2639) internet(1427) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ take(945) account(800) differ(722) }
{ risk(3053) factor(974) diseas(938) }
{ visual(1396) interact(850) tool(830) }
{ cost(1906) reduc(1198) effect(832) }
{ activ(1138) subject(705) human(624) }
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{ can(774) often(719) complex(702) }
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{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ sampl(1606) size(1419) use(1276) }
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{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ can(981) present(881) function(850) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ drug(1928) target(777) effect(648) }
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{ survey(1388) particip(1329) question(1065) }
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Resumo

The ever increasing number of alternative treatment options and the plethora of clinical trials have put systematic reviews and meta-analysis under a new perspective by emphasizing the need to make inferences about competing treatments for the same condition. The statistical component in reviews that compare multiple interventions, network meta-analysis, is the next generation evidence synthesis toolkit which, when properly applied, can serve decision-making better than the established pairwise meta-analysis. The criticism and enthusiasm for network meta-analysis echo those that greeted the advent of simple meta-analysis. The main criticism is associated with the difficulty in evaluating the assumption underlying the statistical synthesis of direct and indirect evidence. In the present article, the assumption of the network meta-analysis are presented using various formulations, the statistical and nonstatistical methodological considerations are elucidated, and the progress achieved in this field is summarized. Throughout, focus is put on highlighting the analogy between the concerns and difficulties that the scientific community had some time ago when advancing from individual trials to their quantitative synthesis via meta-analysis and those currently expressed about the transition from head-to-head meta-analyses to network meta-analysis. Copyright ? 2012 John Wiley & Sons, Ltd.

Resumo Limpo

ever increas number altern treatment option plethora clinic trial put systemat review metaanalysi new perspect emphas need make infer compet treatment condit statist compon review compar multipl intervent network metaanalysi next generat evid synthesi toolkit proper appli can serv decisionmak better establish pairwis metaanalysi critic enthusiasm network metaanalysi echo greet advent simpl metaanalysi main critic associ difficulti evalu assumpt under statist synthesi direct indirect evid present articl assumpt network metaanalysi present use various formul statist nonstatist methodolog consider elucid progress achiev field summar throughout focus put highlight analog concern difficulti scientif communiti time ago advanc individu trial quantit synthesi via metaanalysi current express transit headtohead metaanalys network metaanalysi copyright john wiley son ltd

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