Sci Data - Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo.

Tópicos

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Resumo

Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), in part, due to alterations in gene expression in the endothelium. While numerous in vitro studies have shown how anti-atherogenic flow and pro-atherogenic flow differently regulate gene expression of cultured endothelial cells, similar in vivo studies have been scarce. Recently, we developed a mouse model of atherosclerosis that rapidly develops robust atherosclerosis by partially ligating the left carotid artery (LCA) branches, while using the contralateral right carotid (RCA) as control. We also developed a novel method to collect endothelial-enriched RNAs from the carotids of these animals, which enabled us to perform genome-wide expression analyses of mRNAs and miRNAs in the arterial endothelium exposed to either d-flow or s-flow. These microarray results were used to identify novel mechanosensitive genes such as DNA methyltransferase-1 and miR-712 that play key roles in atherosclerosis. Here, we report these endothelial mRNA and miRNA expression profiles with in-depth information on experimental procedures along with an example of usage of these data.

Resumo Limpo

atherosclerosi preferenti occur arteri region expos disturb blood flow dflow part due alter gene express endothelium numer vitro studi shown antiatherogen flow proatherogen flow differ regul gene express cultur endotheli cell similar vivo studi scarc recent develop mous model atherosclerosi rapid develop robust atherosclerosi partial ligat left carotid arteri lca branch use contralater right carotid rca control also develop novel method collect endothelialenrich rnas carotid anim enabl us perform genomewid express analys mrnas mirna arteri endothelium expos either dflow sflow microarray result use identifi novel mechanosensit gene dna methyltransferas mir play key role atherosclerosi report endotheli mrna mirna express profil indepth inform experiment procedur along exampl usag data

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