Sci Data - Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat.

Tópicos

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Resumo

Identification of mechanisms of resistance to histone deacetylase inhibitors, such as vorinostat, is important in order to utilise these anticancer compounds more efficiently in the clinic. Here, we present a dataset containing multiple tiers of stringent siRNA screening for genes that when knocked down conferred sensitivity to vorinostat-induced cell death. We also present data from a miRNA overexpression screen for miRNAs contributing to vorinostat sensitivity. Furthermore, we provide transcriptomic analysis using massively parallel sequencing upon knockdown of 14 validated vorinostat-resistance genes. These datasets are suitable for analysis of genes and miRNAs involved in cell death in the presence and absence of vorinostat as well as computational biology approaches to identify gene regulatory networks.

Resumo Limpo

identif mechan resist histon deacetylas inhibitor vorinostat import order utilis anticanc compound effici clinic present dataset contain multipl tier stringent sirna screen gene knock confer sensit vorinostatinduc cell death also present data mirna overexpress screen mirna contribut vorinostat sensit furthermor provid transcriptom analysi use massiv parallel sequenc upon knockdown valid vorinostatresist gene dataset suitabl analysi gene mirna involv cell death presenc absenc vorinostat well comput biolog approach identifi gene regulatori network

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