Sci Data - The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance.

Tópicos

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Resumo

Animal muscles must maintain their function and structure while bearing substantial mechanical loads. How muscles withstand persistent mechanical strain is presently not well understood. Understanding the mechanisms by which tissues maintain their complex architecture is a key goal of cell biology. This dataset represents a systematic screen through the Drosophila melanogaster cytoskeleton to identify genes that are required to maintain tissue, specifically muscle, architecture. Using RNA interference (RNAi), we knocked down 238 genes in Drosophila and assayed for climbing ability with a robust behavioural assay. Here we present the summary of the screen and provide the complete results of the assays. We have uncovered a number of novel hits that would reward further study. The data are easy to use: the raw data are provided to allow researchers to perform their own analysis and analysed results are given indicating whether or not the genes are required for muscle maintenance. This dataset will allow other researchers to identify candidate genes for more detailed study and lead to better understanding of muscle maintenance.

Resumo Limpo

anim muscl must maintain function structur bear substanti mechan load muscl withstand persist mechan strain present well understood understand mechan tissu maintain complex architectur key goal cell biolog dataset repres systemat screen drosophila melanogast cytoskeleton identifi gene requir maintain tissu specif muscl architectur use rna interfer rnai knock gene drosophila assay climb abil robust behaviour assay present summari screen provid complet result assay uncov number novel hit reward studi data easi use raw data provid allow research perform analysi analys result given indic whether gene requir muscl mainten dataset will allow research identifi candid gene detail studi lead better understand muscl mainten

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