BMC Med Inform Decis Mak - Temporal aggregation impacts on epidemiological simulations employing microcontact data.

Tópicos

{ model(2220) cell(1177) simul(1124) }
{ time(1939) patient(1703) rate(768) }
{ risk(3053) factor(974) diseas(938) }
{ studi(2440) review(1878) systemat(933) }
{ system(1050) medic(1026) inform(1018) }
{ measur(2081) correl(1212) valu(896) }
{ patient(2315) diseas(1263) diabet(1191) }
{ data(2317) use(1299) case(1017) }
{ imag(1947) propos(1133) code(1026) }
{ system(1976) rule(880) can(841) }
{ network(2748) neural(1063) input(814) }
{ framework(1458) process(801) describ(734) }
{ patient(2837) hospit(1953) medic(668) }
{ sampl(1606) size(1419) use(1276) }
{ analysi(2126) use(1163) compon(1037) }
{ survey(1388) particip(1329) question(1065) }
{ imag(2830) propos(1344) filter(1198) }
{ method(1557) propos(1049) approach(1037) }
{ care(1570) inform(1187) nurs(1089) }
{ import(1318) role(1303) understand(862) }
{ perform(1367) use(1326) method(1137) }
{ high(1669) rate(1365) level(1280) }
{ can(774) often(719) complex(702) }
{ imag(1057) registr(996) error(939) }
{ error(1145) method(1030) estim(1020) }
{ model(2341) predict(2261) use(1141) }
{ record(1888) medic(1808) patient(1693) }
{ monitor(1329) mobil(1314) devic(1160) }
{ can(981) present(881) function(850) }
{ method(2212) result(1239) propos(1039) }
{ model(3404) distribut(989) bayesian(671) }
{ method(1219) similar(1157) match(930) }
{ motion(1329) object(1292) video(1091) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ case(1353) use(1143) diagnosi(1136) }
{ studi(1410) differ(1259) use(1210) }
{ research(1085) discuss(1038) issu(1018) }
{ model(3480) simul(1196) paramet(876) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ patient(1821) servic(1111) care(1106) }
{ health(1844) social(1437) communiti(874) }
{ decis(3086) make(1611) patient(1517) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2675) segment(2577) method(1081) }
{ take(945) account(800) differ(722) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ extract(1171) text(1153) clinic(932) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ perform(999) metric(946) measur(919) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ health(3367) inform(1360) care(1135) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ first(2504) two(1366) second(1323) }
{ activ(1138) subject(705) human(624) }
{ use(2086) technolog(871) perceiv(783) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }

Resumo

CKGROUND: Microcontact datasets gathered automatically by electronic devices have the potential augment the study of the spread of contagious disease by providing detailed representations of the study population's contact dynamics. However, the impact of data collection experimental design on the subsequent simulation studies has not been adequately addressed. In particular, the impact of study duration and contact dynamics data aggregation on the ultimate outcome of epidemiological models has not been studied in detail, leaving the potential for erroneous conclusions to be made based on simulation outcomes.METHODS: We employ a previously published data set covering 36 participants for 92 days and a previously published agent-based H1N1 infection model to analyze the impact of contact dynamics representation on the simulated outcome of H1N1 transmission. We compared simulated attack rates resulting from the empirically recorded contact dynamics (ground truth), aggregated, typical day, and artificially generated synthetic networks.RESULTS: No aggregation or sampling policy tested was able to reliably reproduce results from the ground-truth full dynamic network. For the population under study, typical day experimental designs - which extrapolate from data collected over a brief period - exhibited too high a variance to produce consistent results. Aggregated data representations systematically overestimated disease burden, and synthetic networks only reproduced the ground truth case when fitting errors systemically underestimated the total contact, compensating for the systemic overestimation from aggregation.CONCLUSIONS: The interdepedendencies of contact dynamics and disease transmission require that detailed contact dynamics data be employed to secure high fidelity in simulation outcomes of disease burden in at least some populations. This finding serves as motivation for larger, longer and more socially diverse contact dynamics tracing experiments and as a caution to researchers employing calibrated aggregate synthetic representations of contact dynamics in simulation, as the calibration may underestimate disease parameters to compensate for the overestimation of disease burden imposed by the aggregate contact network representation.

Resumo Limpo

ckground microcontact dataset gather automat electron devic potenti augment studi spread contagi diseas provid detail represent studi popul contact dynam howev impact data collect experiment design subsequ simul studi adequ address particular impact studi durat contact dynam data aggreg ultim outcom epidemiolog model studi detail leav potenti erron conclus made base simul outcomesmethod employ previous publish data set cover particip day previous publish agentbas hn infect model analyz impact contact dynam represent simul outcom hn transmiss compar simul attack rate result empir record contact dynam ground truth aggreg typic day artifici generat synthet networksresult aggreg sampl polici test abl reliabl reproduc result groundtruth full dynam network popul studi typic day experiment design extrapol data collect brief period exhibit high varianc produc consist result aggreg data represent systemat overestim diseas burden synthet network reproduc ground truth case fit error system underestim total contact compens system overestim aggregationconclus interdepedend contact dynam diseas transmiss requir detail contact dynam data employ secur high fidel simul outcom diseas burden least popul find serv motiv larger longer social divers contact dynam trace experi caution research employ calibr aggreg synthet represent contact dynam simul calibr may underestim diseas paramet compens overestim diseas burden impos aggreg contact network represent

Resumos Similares

Med Biol Eng Comput - Biomechanical analysis of traumatic mesenteric avulsion. ( 0,804554383992975 )
Int J Comput Assist Radiol Surg - Bivariate optimization of orthodontic mini-implant thread height and pitch. ( 0,795486521210456 )
Med Biol Eng Comput - Clinically oriented real-time monitoring of the individual's risk for deep tissue injury. ( 0,793240341330019 )
Med Biol Eng Comput - Finite element analysis of the influence of loading rate on a model of the full lumbar spine under dynamic loading conditions. ( 0,787466571558709 )
Comput. Biol. Med. - Biological-data-based finite-element stress analysis of mandibular bone with implant-supported overdenture. ( 0,784220478189053 )
Comput Math Methods Med - The HYP-RT hypoxic tumour radiotherapy algorithm and accelerated repopulation dose per fraction study. ( 0,781768225424569 )
Wiley Interdiscip Rev Syst Biol Med - Ischemic kidney injury and mechanisms of tissue repair. ( 0,777654938010138 )
Med Biol Eng Comput - Strain rate-dependent viscohyperelastic constitutive modeling of bovine liver tissue. ( 0,775049652783909 )
Med Biol Eng Comput - Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma. ( 0,774610424643411 )
Med Biol Eng Comput - Sensitivity of patient-specific vertebral finite element model from low dose imaging to material properties and loading conditions. ( 0,769543952444203 )
Int J Comput Assist Radiol Surg - Surgical stent planning: simulation parameter study for models based on DICOM standards. ( 0,766748948688609 )
Comput. Biol. Med. - Protein transport in the connecting cilium of a photoreceptor cell: modeling the effects of bidirectional protein transitions between the diffusion-driven and motor-driven kinetic states. ( 0,766640144833214 )
Med Biol Eng Comput - A three-dimensional finite element model of the cervical spine: an investigation of whiplash injury. ( 0,764126285165466 )
Med Biol Eng Comput - Calibration of the mechanical properties in a finite element model of a lumbar vertebra under dynamic compression up to failure. ( 0,76400742864697 )
Med Biol Eng Comput - Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? ( 0,757905609669239 )
Comput Methods Programs Biomed - A phenomenological mathematical model of the articular cartilage damage. ( 0,75757064683936 )
Comput. Biol. Med. - Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments. ( 0,756933033483748 )
Med Biol Eng Comput - In-silico modeling of atrial repolarization in normal and atrial fibrillation remodeled state. ( 0,756227437222987 )
Med Biol Eng Comput - Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. ( 0,755972980064482 )
Comput Methods Programs Biomed - Experiment and hydro-mechanical coupling simulation study on the human periodontal ligament. ( 0,753803157759907 )
Comput Math Methods Med - A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. ( 0,749330063703945 )
Med Biol Eng Comput - A new method to include the gravitational forces in a finite element model of the scoliotic spine. ( 0,746641789949977 )
Comput Math Methods Med - Morphological measurement of living cells in methanol with digital holographic microscopy. ( 0,745720721292785 )
Med Biol Eng Comput - Sensitivity studies of pediatric material properties on juvenile lumbar spine responses using finite element analysis. ( 0,745011241718846 )
Med Biol Eng Comput - Validation efforts and flexibilities of an eight-year-old human juvenile lumbar spine using a three-dimensional finite element model. ( 0,743921200484584 )
Med Biol Eng Comput - Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. ( 0,742296521350777 )
Med Biol Eng Comput - Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study. ( 0,742292107949854 )
Med Biol Eng Comput - Biomechanics of thoracolumbar junction vertebral fractures from various kinematic conditions. ( 0,741122042963338 )
Med Biol Eng Comput - Modeling and experimental methods to predict oxygen distribution in bone defects following cell transplantation. ( 0,73926861292977 )
Med Biol Eng Comput - Mathematical modeling of stem cell proliferation. ( 0,738732065100927 )
Med Biol Eng Comput - Effects of skin wrinkles, age and wetness on mechanical loads in the stratum corneum as related to skin lesions. ( 0,736221808226846 )
Comput Math Methods Med - Recent advances in computational mechanics of the human knee joint. ( 0,732436315860652 )
Med Biol Eng Comput - Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation. ( 0,731680531611851 )
Comput. Biol. Med. - Tooth fracture risk analysis based on a new finite element dental structure models using micro-CT data. ( 0,73006707298102 )
Comput Biol Chem - Modeling of tumor growth in dendritic cell-based immunotherapy using artificial neural networks. ( 0,729702502969176 )
Med Biol Eng Comput - A nonlinear finite element simulation of balloon expandable stent for assessment of plaque vulnerability inside a stenotic artery. ( 0,729069197548722 )
J Med Syst - Post-operative assessment of an implant fixation in anterior cruciate ligament reconstructive surgery. ( 0,728773720208647 )
Comput Methods Programs Biomed - Subject-specific finite element simulation of the human femur considering inhomogeneous material properties: a straightforward method and convergence study. ( 0,727225318832033 )
Med Biol Eng Comput - Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. ( 0,724415009450947 )
J Chem Inf Model - Computational modeling of kinesin stepping. ( 0,723104819445047 )
Med Biol Eng Comput - Biomechanical modeling of brace treatment of scoliosis: effects of gravitational loads. ( 0,722474011111632 )
Comput Math Methods Med - Contribution to the determination of in vivo mechanical characteristics of human skin by indentation test. ( 0,721142088857858 )
Med Biol Eng Comput - The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment. ( 0,720992866768428 )
Comput. Biol. Med. - Application of an anatomically-detailed finite element thorax model to investigate pediatric cardiopulmonary resuscitation techniques on hard bed. ( 0,719724502717058 )
Med Biol Eng Comput - 3D finite element analysis on esthetic indirect dental restorations under thermal and mechanical loading. ( 0,719260518508308 )
Comput. Biol. Med. - Estimation of the reliability of all-ceramic crowns using finite element models and the stress-strength interference theory. ( 0,718018765679072 )
Comput. Biol. Med. - A computational study of the respiratory airflow characteristics in normal and obstructed human airways. ( 0,716691467070771 )
Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model. ( 0,716229266341865 )
Comput Methods Programs Biomed - Growth plate stress distribution implications during bone development: a simple framework computational approach. ( 0,715621426026684 )
Med Biol Eng Comput - Modeling and analysis of coagulated liver tissue and its interaction with a scalpel blade. ( 0,712789146029398 )
Med Biol Eng Comput - Modeling of the dielectric properties of trabecular bone samples at microwave frequency. ( 0,709142754228723 )
Comput Math Methods Med - A finite element study of micropipette aspiration of single cells: effect of compressibility. ( 0,708812555468402 )
Comput Math Methods Med - Comparative evaluation of osseointegrated dental implants based on platform-switching concept: influence of diameter, length, thread shape, and in-bone positioning depth on stress-based performance. ( 0,706545697120157 )
Med Biol Eng Comput - Finite element modeling of mitral leaflet tissue using a layered shell approximation. ( 0,706442615908648 )
Comput Math Methods Med - The influence of the specimen shape and loading conditions on the parameter identification of a viscoelastic brain model. ( 0,70575118012259 )
Comput. Biol. Med. - Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. ( 0,705741869488833 )
Med Biol Eng Comput - Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential. ( 0,705429550672636 )
Comput Math Methods Med - Fluid structural analysis of human cerebral aneurysm using their own wall mechanical properties. ( 0,705044588588843 )
Int J Comput Assist Radiol Surg - Real-time simulation of the nonlinear visco-elastic deformations of soft tissues. ( 0,702858770784503 )
Comput Methods Programs Biomed - Anthropometric dependence of the response of a thorax FE model under high speed loading: validation and real world accident replication. ( 0,700692451828084 )
Med Biol Eng Comput - Biomechanical comparison of fusionless growth modulation corrective techniques in pediatric scoliosis. ( 0,700144212415944 )
Int J Comput Assist Radiol Surg - Reality based modeling and simulation of gallbladder shape deformation using variational methods. ( 0,697320863732361 )
Comput Methods Programs Biomed - Modelling of mandible bone properties in the numerical analysis of oral implant biomechanics. ( 0,697133720919993 )
Int J Comput Assist Radiol Surg - Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation. ( 0,696291255412925 )
Comput Methods Programs Biomed - Monte Carlo method for photon heating using temperature-dependent optical properties. ( 0,696255547051938 )
Comput Methods Programs Biomed - Optimal bone density distributions: numerical analysis of the osteocyte spatial influence in bone remodeling. ( 0,695332112395834 )
Med Biol Eng Comput - Effects of simulated injury on the anteroinferior glenohumeral capsule. ( 0,694066759472221 )
IEEE J Biomed Health Inform - Skin Temperature Prediction in Lower Limb Prostheses. ( 0,691421671479628 )
Comput Math Methods Med - The effect of inhibitory neuron on the evolution model of higher-order coupling neural oscillator population. ( 0,687905099934741 )
Comput Math Methods Med - Quantitative imaging of young's modulus of soft tissues from ultrasound water jet indentation: a finite element study. ( 0,687824994476634 )
Comput. Biol. Med. - Biomechanical simulation of various surface roughnesses and geometric designs on an immediately loaded dental implant. ( 0,687720616197948 )
Comput. Aided Surg. - Computer-assisted measurements of coronal knee joint laxity in vitro are related to low-stress behavior rather than structural properties of the collateral ligaments. ( 0,68474270280685 )
Comput. Biol. Med. - Dynamic finite element analysis and moving particle simulation of human enamel on a microscale. ( 0,684460742547293 )
Comput Math Methods Med - Modeling the relationship between fluorodeoxyglucose uptake and tumor radioresistance as a function of the tumor microenvironment. ( 0,682144206772489 )
Comput. Biol. Med. - Modeling porous scaffold microstructure by a reaction-diffusion system and its degradation by hydrolysis. ( 0,681866855084533 )
Neural Comput - Deficient GABAergic gliotransmission may cause broader sensory tuning in schizophrenia. ( 0,681592751599296 )
Neural Comput - Ambient GABA responsible for age-related changes in multistable perception. ( 0,679741670859196 )
Comput Math Methods Med - Study of tumor growth under hyperthermia condition. ( 0,678173490469331 )
Comput Methods Programs Biomed - Determination of nonlinear fibre-reinforced biphasic poroviscoelastic constitutive parameters of articular cartilage using stress relaxation indentation testing and an optimizing finite element analysis. ( 0,678032434203957 )
Comput Math Methods Med - A literature review of the numerical analysis of abdominal aortic aneurysms treated with endovascular stent grafts. ( 0,67783209386716 )
Med Biol Eng Comput - Patient-specific finite element modeling of the Cardiokinetix Parachute(?) device: effects on left ventricular wall stress and function. ( 0,674942784410932 )
Med Biol Eng Comput - Development of a subject-specific model to predict the forces in the knee ligaments at high flexion angles. ( 0,672666104808238 )
Comput Methods Programs Biomed - HiL simulation in biomechanics: a new approach for testing total joint replacements. ( 0,670116159639078 )
Comput Methods Programs Biomed - Computational analysis of cartilage implants based on an interpenetrated polymer network for tissue repairing. ( 0,667991871015642 )
Med Biol Eng Comput - Estimation of the retainer height biomechanical contribution in posterior resin-bonded fixed partial dentures: a structural-thermal coupled finite element analysis. ( 0,666364348039159 )
Comput Methods Programs Biomed - A patient specific electro-mechanical model of the heart. ( 0,665624344425157 )
Int J Med Robot - A physics-based algorithm for real-time simulation of electrosurgery procedures in minimally invasive surgery. ( 0,66214998630821 )
Med Biol Eng Comput - Microfabricated substrates as a tool to study cell mechanotransduction. ( 0,661854362457671 )
Med Biol Eng Comput - Biomechanical analysis of the effects of medial meniscectomy on degenerative osteoarthritis. ( 0,660891255188654 )
Comput Methods Programs Biomed - Physical modeling with orthotropic material based on harmonic fields. ( 0,65915866005269 )
Med Biol Eng Comput - 3D network model of NO transport in tissue. ( 0,657335246139141 )
Comput. Biol. Med. - Prediction of stress shielding around an orthopedic screw: using stress and strain energy density as mechanical stimuli. ( 0,657326241338999 )
Comput Math Methods Med - A computational modeling approach for investigating soft tissue balancing in bicruciate retaining knee arthroplasty. ( 0,655233226684875 )
Comput. Biol. Med. - Modeling skin thermal pain sensation: Role of non-Fourier thermal behavior in transduction process of nociceptor. ( 0,654309953457652 )
Wiley Interdiscip Rev Syst Biol Med - Integrative approaches for modeling regulation and function of the respiratory system. ( 0,654239253492446 )
Comput Math Methods Med - Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis. ( 0,649690555247543 )
Comput. Biol. Med. - Modeling of tumor growth undergoing virotherapy. ( 0,649605742702308 )
Comput. Biol. Med. - Mathematical model of the coagulation in the bone-dental implant interface. ( 0,648628624477145 )
Int J Comput Assist Radiol Surg - In-silico oncology: an approximate model of brain tumor mass effect based on directly manipulated free form deformation. ( 0,647494399549563 )
Comput. Biol. Med. - Design, analysis and verification of a knee joint oncological prosthesis finite element model. ( 0,647314011789768 )